4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitor

Xu, Guozhang; Abad, Marta C.; Connolly, Peter J.; Neeper, Michael P.; Struble, Geoffrey T.; Springer, Barry A.; L.Emanuel, Stuart; Pandey, Niranjan; Gruninger, Robert H.; Adams, Mary; Moreno-Mazza, Sandra; Fuentes-Pesquera, Angel R.; Middleton, Steven A.

doi:10.1016/j.bmcl.2008.07.020

4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitor

Journal Article · Fri Aug 01 00:00:00 EDT 2008 · Bioorg. Med. Chem. Lett.

DOI:https://doi.org/10.1016/j.bmcl.2008.07.020· OSTI ID:1900674

Xu, Guozhang; Abad, Marta C.; Connolly, Peter J.; Neeper, Michael P.; Struble, Geoffrey T.; Springer, Barry A.; L.Emanuel, Stuart; Pandey, Niranjan; Gruninger, Robert H.; Adams, Mary; Moreno-Mazza, Sandra; Fuentes-Pesquera, Angel R.; Middleton, Steven A.

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1900674

Journal Information:: Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (16) Vol. 18

Country of Publication:: United States

Language:: ENGLISH

References (12)

New dual inhibitors of EGFR and HER2 protein tyrosine kinases Fink, Brian E.; Vite, Gregory D.; Mastalerz, Harold Bioorganic & Medicinal Chemistry Letters, Vol. 15, Issue 21 https://doi.org/10.1016/j.bmcl.2005.07.027	journal	November 2005
The Epidermal Growth Factor Receptor and Its Inhibition in Cancer Therapy Woodburn, J. R. Pharmacology & Therapeutics, Vol. 82, Issue 2-3 https://doi.org/10.1016/S0163-7258(98)00045-X	journal	May 1999
Epidermal growth factor-related peptides and their receptors in human malignancies Salomon, David S.; Brandt, Ralf; Ciardiello, Fortunato Critical Reviews in Oncology/Hematology, Vol. 19, Issue 3 https://doi.org/10.1016/1040-8428(94)00144-I	journal	July 1995
A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib): Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells Wood, Edgar R.; Truesdale, Anne T.; McDonald, Octerloney B. Cancer Research, Vol. 64, Issue 18 https://doi.org/10.1158/0008-5472.CAN-04-1168	journal	September 2004
Role of an Anti-epidermal Growth Factor Receptor in Treating Cancer Waksal, Harlan W. Cancer and Metastasis Reviews, Vol. 18, Issue 4, p. 427-436 https://doi.org/10.1023/A:1006302101468	journal	January 1999
NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer Olayioye, M. A. The EMBO Journal, Vol. 19, Issue 13 https://doi.org/10.1093/emboj/19.13.3159	journal	July 2000
Design, Synthesis, and Structure−Activity Relationship of 6-Alkynylpyrimidines as Potent Adenosine Kinase Inhibitors Gomtsyan, Arthur; Didomenico, Stanley; Lee, Chih-Hung Journal of Medicinal Chemistry, Vol. 45, Issue 17 https://doi.org/10.1021/jm020049a	journal	July 2002
Hopes ride on drug Candidates Borman, Stu Chemical & Engineering News Archive, Vol. 83, Issue 16 https://doi.org/10.1021/cen-v083n016.p040	journal	April 2005
Discovery and Biological Evaluation of Potent Dual ErbB-2/EGFR Tyrosine Kinase Inhibitors: 6-Thiazolylquinazolines Gaul, Micheal D.; Guo, Yu; Affleck, Karen Bioorganic & Medicinal Chemistry Letters, Vol. 13, Issue 4 https://doi.org/10.1016/S0960-894X(02)01047-8	journal	February 2003
Prevalence of aberrant expression of the epidermal growth factor receptor in human cancers Gullick, W. J. British Medical Bulletin, Vol. 47, Issue 1 https://doi.org/10.1093/oxfordjournals.bmb.a072464	journal	January 1991
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. Baselga, J.; Tripathy, D.; Mendelsohn, J. Journal of Clinical Oncology, Vol. 14, Issue 3 https://doi.org/10.1200/JCO.1996.14.3.737	journal	March 1996
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases Xu, Guozhang; Searle, Lily Lee; Hughes, Terry V. Bioorganic & Medicinal Chemistry Letters, Vol. 18, Issue 12 https://doi.org/10.1016/j.bmcl.2008.05.024	journal	June 2008

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