Global trends in Akkermansia muciniphila research: A bibliometric visualization

Li, Zitong; Ke, Haoran; Wang, Ying; Chen, Shuze; Liu, Xiuying; Lin, Qianyun; Wang, Pu; Chen, Ye

doi:10.3389/fmicb.2022.1037708

Global trends in Akkermansia muciniphila research: A bibliometric visualization

Journal Article · Wed Nov 09 23:00:00 EST 2022 · Frontiers in Microbiology

DOI:https://doi.org/10.3389/fmicb.2022.1037708· OSTI ID:1897776

Li, Zitong; Ke, Haoran; Wang, Ying; Chen, Shuze; Liu, Xiuying; Lin, Qianyun; Wang, Pu; Chen, Ye

Background

Akkermansia muciniphila is a member of the gut microbiome, using mucin as sources of carbon, nitrogen, and energy. Since the first discovery of this unique bacterium in 2004, A. muciniphila has been extensively studied. It is considered a promising “next-generation beneficial microbe.” The purpose of this paper is to sort out the research status and summarize the hotspots through bibliometric analysis of the publications of A. muciniphila.

Methods

The publications about A. muciniphila from January 2004 to February 2022 were obtained from the Web of Science Core Collection. Visualization analyses were performed using three bibliometric tools and GraphPad Prism.

Results

A total of 1,478 published documents were analyzed. Annual publication number grew from 1 in 2004 to 336 in 2021, with China being the leading producer (33.36%). De Vos, Willem M was the most productive author with the highest H-index (documents = 56, H-index = 37), followed by Cani, Patrice D (documents = 35, H-index = 25). And Scientific Reports published the most papers. PNAS was the keystone taxa in this field, with high betweenness centrality (0.11) and high frequency. The keywords with high frequency in recent years include: oxidative stress, diet, metformin, fecal microbiota transplantation, short-chain fatty acids, polyphenols, microbiota metabolites and so on. The keyword “oxidative stress” was observed to be increasing in frequency recently.

Conclusion

Over time, the scope of the research on the clinical uses of A. muciniphila has gradually increased, and was gradually deepened and developed toward a more precise level. A. muciniphila is likely to remain a research hotspot in the foreseeable future and may contribute to human health.

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 1897776

Journal Information:: Frontiers in Microbiology, Journal Name: Frontiers in Microbiology Vol. 13; ISSN 1664-302X

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

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