Methods and systems for producing nanolipoprotein particles

Coleman, Matthew A.; Hoeprich, Jr., Paul D.; Segelke, Brent W.

Methods and systems for producing nanolipoprotein particles

Patent · Tue Apr 12 04:00:00 EDT 2022

OSTI ID:1892822

Coleman, Matthew A.; Hoeprich, Jr., Paul D.; Segelke, Brent W.

Provided herein are methods and systems for the production of a nanolipoprotein particle (NLP) that includes a scaffold protein a membrane forming lipid and optionally a target protein. At least one of the scaffold protein and target protein can be provided through an IVT system. The membrane forming lipid, scaffold protein and optionally the target protein can be assembled for a time and under conditions that allow obtaining high yield NLPs, NPLs with an increased solubility, an NLP of a controlled size, and/or an NLP having a size predetermined to include a pre-selected target protein.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 11,300,572

Application Number:: 16/159,189

OSTI ID:: 1892822

Country of Publication:: United States

Language:: English

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