Basis for the ICRP’s updated biokinetic model for systemic astatine

Leggett, Rich Wayne; Samuels, Caleigh

doi:10.1088/1361-6498/ac48e2

Basis for the ICRP’s updated biokinetic model for systemic astatine

Journal Article · Tue Feb 01 00:00:00 EST 2022 · Journal of Radiological Protection

DOI:https://doi.org/10.1088/1361-6498/ac48e2· OSTI ID:1883957

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Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The International Commission on Radiological Protection (ICRP) recently updated its biokinetic models for workers in a series of reports called the OIR (occupational intakes of radionuclides) series. A new biokinetic model for astatine (At), the heaviest member of the halogen family, was adopted in OIR Part 5 (ICRP in press). Occupational intakes of radionuclides: Part 5). Furthermore, this paper provides an overview of available biokinetic data for At; describes the basis for the ICRP's updated model for At; and tabulates dose coefficients for intravenous injection of each of the two longest lived and most important At isotopes, ²¹¹At and ²¹⁰At. At-211 (T_1/2 = 7.214 h) is a promising radionuclide for use in targeted α-particle therapy due to several favourable properties including its half-life and the absence of progeny that could deliver significant radiation doses outside the region of α-particle therapy. At-210 (T_1/2 = 8.1 h) is an impurity generated in the production of ²¹¹At in a cyclotron and represents a potential radiation hazard via its long-lived progeny ²¹⁰Po (T_1/2 = 138 days). Tissue dose coefficients for injected ²¹⁰At and ²¹¹At based on the updated model are shown to differ considerably from values based on the ICRP's previous model for At, particularly for the thyroid, stomach wall, salivary glands, lungs, spleen, and kidneys.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1883957

Journal Information:: Journal of Radiological Protection, Journal Name: Journal of Radiological Protection Journal Issue: 2 Vol. 42; ISSN 0952-4746

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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