Updated biokinetic model for systemic americium

Leggett, Rich Wayne; Blanchardon, Eric

doi:10.1088/1361-6498/ab0d3b

Updated biokinetic model for systemic americium

Journal Article · Fri May 03 00:00:00 EDT 2019 · Journal of Radiological Protection

DOI:https://doi.org/10.1088/1361-6498/ab0d3b· OSTI ID:1557525

^[1]; Blanchardon, Eric ^[2]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Inst. for Radiological Protection and Nuclear Safety(IRSN), Cedex (France)

The biokinetic model for systemic americium (Am) currently recommended by the International Commission on Radiological Protection (ICRP) for application to occupational intake of Am is based on information available through the early 1990s. Much additional information on Am biokinetics has been developed in the past 25 y, including measurements of retention and excretion of ²⁴¹Am in many workers with ²⁴¹Am burdens and post mortem measurements of ²⁴¹Am in tissues of some of those workers. The ICRP's current Am model is reasonably consistent with the updated information, with the main exception that the current model apparently overestimates 24-hour urinary Am as a fraction of skeletal or systemic Am at late times after intake. This paper provides an overview of current information on the systemic kinetics of Am in adult human subjects and laboratory animals and presents an updated biokinetic model for systemic Am that addresses the discrepancies between the current database and current ICRP systemic model for Am. Here, this model is applied in Part 4 (to appear) of an ICRP series of reports on intake of radionuclides by workers called the OIR (Occupational Intake of Radionuclides) series.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1557525

Alternate ID(s):: OSTI ID: 22914742

Journal Information:: Journal of Radiological Protection, Journal Name: Journal of Radiological Protection Journal Issue: 2 Vol. 39; ISSN 0952-4746

Publisher:: IOP PublishingCopyright Statement

Country of Publication:: United States

Language:: English

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Updated biokinetic model for systemic americium

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