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Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol

Journal Article · · Frontiers in Medicine
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  1. Univ. of Iowa, Iowa City, IA (United States)
  2. St. Ambrose Univ., Davenport, IA (United States)
  3. Rush Univ. Medical Center, Chicago, IL (United States)
  4. Univ. of Illinois, Chicago, IL (United States)
  5. NorthShore University HealthSystem, Skokie, IL (United States)
  6. Univ. of Chicago, IL (United States)
  7. Univ. of Michigan, Ann Arbor, MI (United States)
  8. Univ. of California, San Diego, CA (United States)
  9. Wake Forest Univ., Winston-Salem, NC (United States)
  10. Univ. of California, Davis, CA (United States)
  11. Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
  12. Univ. of Pittsburgh, PA (United States)
  13. Johns Hopkins Univ., Baltimore, MD (United States)
  14. Univ. of Texas, Austin, TX (United States)
  15. Dartmouth College, Hanover, NH (United States)
  16. National Institutes of Health (NIH), Bethesda, MD (United States)
+ Show Author Affiliations
Chronic pain has become a global health problem contributing to years lived with disability and reduced quality of life. Advances in the clinical management of chronic pain have been limited due to incomplete understanding of the multiple risk factors and molecular mechanisms that contribute to the development of chronic pain. The Acute to Chronic Pain Signatures (A2CPS) Program aims to characterize the predictive nature of biomarkers (brain imaging, high-throughput molecular screening techniques, or “omics,” quantitative sensory testing, patient-reported outcome assessments and functional assessments) to identify individuals who will develop chronic pain following surgical intervention. The A2CPS is a multisite observational study investigating biomarkers and collective biosignatures (a combination of several individual biomarkers) that predict susceptibility or resilience to the development of chronic pain following knee arthroplasty and thoracic surgery. This manuscript provides an overview of data collection methods and procedures designed to standardize data collection across multiple clinical sites and institutions. Pain-related biomarkers are evaluated before surgery and up to 3 months after surgery for use as predictors of patient reported outcomes 6 months after surgery. The dataset from this prospective observational study will be available for researchers internal and external to the A2CPS Consortium to advance understanding of the transition from acute to chronic postsurgical pain.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE
Contributing Organization:
The Acute to Chronic Pain Signatures Consortium
Grant/Contract Number:
AC05-76RL01830
OSTI ID:
1882664
Report Number(s):
PNNL-SA-169089
Journal Information:
Frontiers in Medicine, Journal Name: Frontiers in Medicine Vol. 9; ISSN 2296-858X
Publisher:
Frontiers Media S.A.Copyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
biomarker
pain
postsurgical pain
protocol
risk factors
thoracic surgery
total knee arthroplasty