Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recogniti

Chu, Kit-Yee; Malik, Anjali; Thamilselvan, Vijayalakshmi; Martinez-Hackert, Erik

doi:10.1016/j.jbc.2022.102076

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recogniti

Journal Article · 01 July 2022 · J. Biol. Chem.

DOI:https://doi.org/10.1016/j.jbc.2022.102076· OSTI ID:1877199

Chu, Kit-Yee; Malik, Anjali; Thamilselvan, Vijayalakshmi; Martinez-Hackert, Erik

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; NIGMS

OSTI ID:: 1877199

Journal Information:: J. Biol. Chem., Vol. 298, Issue (7)

Country of Publication:: United States

Language:: ENGLISH

References (51)

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Perrimon, N.; Pitsouli, C.; Shilo, B. -Z. Cold Spring Harbor Perspectives in Biology, Vol. 4, Issue 8 https://doi.org/10.1101/cshperspect.a005975	journal	August 2012
TGF-β signalling from cell membrane to nucleus through SMAD proteins Heldin, Carl-Henrik; Miyazono, Kohei; ten Dijke, Peter Nature, Vol. 390, Issue 6659 https://doi.org/10.1038/37284	journal	December 1997
Tgf-β Signal Transduction Massagué, J. Annual Review of Biochemistry, Vol. 67, Issue 1 https://doi.org/10.1146/annurev.biochem.67.1.753	journal	June 1998
Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom Huminiecki, Lukasz; Goldovsky, Leon; Freilich, Shiri BMC Evolutionary Biology, Vol. 9, Issue 1 https://doi.org/10.1186/1471-2148-9-28	journal	January 2009
Divergence and convergence of TGF-?/BMP signaling Miyazono, Kohei; Kusanagi, Kiyoshi; Inoue, Hirofumi Journal of Cellular Physiology, Vol. 187, Issue 3 https://doi.org/10.1002/jcp.1080	journal	January 2001
The regulation of TGFβ signal transduction Moustakas, Aristidis; Heldin, Carl-Henrik Development, Vol. 136, Issue 22 https://doi.org/10.1242/dev.030338	journal	November 2009
Receptor binding competition: A paradigm for regulating TGF-β family action Martinez-Hackert, Erik; Sundan, Anders; Holien, Toril Cytokine & Growth Factor Reviews, Vol. 57 https://doi.org/10.1016/j.cytogfr.2020.09.003	journal	February 2021
Promiscuity and specificity in BMP receptor activation Mueller, Thomas D.; Nickel, Joachim FEBS Letters, Vol. 586, Issue 14 https://doi.org/10.1016/j.febslet.2012.02.043	journal	March 2012
Specificity, versatility, and control of TGF-β family signaling Derynck, Rik; Budi, Erine H. Science Signaling, Vol. 12, Issue 570 https://doi.org/10.1126/scisignal.aav5183	journal	February 2019
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop Aykul, Senem; Corpina, Richard A.; Goebel, Erich J. eLife, Vol. 9 https://doi.org/10.7554/eLife.54582	journal	June 2020
Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily Hinck, Andrew P. FEBS Letters, Vol. 586, Issue 14 https://doi.org/10.1016/j.febslet.2012.05.028	journal	May 2012
Structural biology of the TGFβ family Goebel, Erich J.; Hart, Kaitlin N.; McCoy, Jason C. Experimental Biology and Medicine, Vol. 244, Issue 17 https://doi.org/10.1177/1535370219880894	journal	October 2019
Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding Groppe, Jay; Hinck, Cynthia S.; Samavarchi-Tehrani, Payman Molecular Cell, Vol. 29, Issue 2 https://doi.org/10.1016/j.molcel.2007.11.039	journal	February 2008
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions Thompson, T. B. The EMBO Journal, Vol. 22, Issue 7 https://doi.org/10.1093/emboj/cdg156	journal	April 2003
Structure of the ternary signaling complex of a TGF-beta superfamily member Allendorph, G. P.; Vale, W. W.; Choe, S. Proceedings of the National Academy of Sciences, Vol. 103, Issue 20 https://doi.org/10.1073/pnas.0602558103	journal	May 2006
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor Weber, Dionys; Kotzsch, Alexander; Nickel, Joachim BMC Structural Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1472-6807-7-6	journal	February 2007
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex Townson, Sharon A.; Martinez-Hackert, Erik; Greppi, Chloe Journal of Biological Chemistry, Vol. 287, Issue 33 https://doi.org/10.1074/jbc.M112.377960	journal	June 2012
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity Goebel, Erich J.; Corpina, Richard A.; Hinck, Cynthia S. Proceedings of the National Academy of Sciences, Vol. 116, Issue 31 https://doi.org/10.1073/pnas.1906253116	journal	July 2019
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family Hart, Kaitlin N.; Stocker, William A.; Nagykery, Nicholas G. Proceedings of the National Academy of Sciences, Vol. 118, Issue 26 https://doi.org/10.1073/pnas.2104809118	journal	June 2021
High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: Implications for ligand binding Mace, Peter D.; Cutfield, John F.; Cutfield, Sue M. Biochemical and Biophysical Research Communications, Vol. 351, Issue 4 https://doi.org/10.1016/j.bbrc.2006.10.109	journal	December 2006
Characterization of Ligand-Binding Properties of the Human BMP Type II Receptor Extracellular Domain Yin, Huiran; Yeh, Lee-Chuan C.; Hinck, Andrew P. Journal of Molecular Biology, Vol. 378, Issue 1 https://doi.org/10.1016/j.jmb.2008.02.031	journal	April 2008
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II Kirsch, Thomas; Nickel, Joachim; Sebald, Walter The EMBO Journal, Vol. 19, Issue 13, p. 3314-3324 https://doi.org/10.1093/emboj/19.13.3314	journal	July 2000
Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs Liu, F.; Ventura, F.; Doody, J. Molecular and Cellular Biology, Vol. 15, Issue 7 https://doi.org/10.1128/MCB.15.7.3479	journal	July 1995
The Mode of Bone Morphogenetic Protein (BMP) Receptor Oligomerization Determines Different BMP-2 Signaling Pathways Nohe, Anja; Hassel, Sylke; Ehrlich, Marcelo Journal of Biological Chemistry, Vol. 277, Issue 7, p. 5330-5338 https://doi.org/10.1074/jbc.M102750200	journal	November 2001
BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics Hiepen, Christian; Jatzlau, Jerome; Hildebrandt, Susanne PLOS Biology, Vol. 17, Issue 12 https://doi.org/10.1371/journal.pbio.3000557	journal	December 2019
A systematic review of genetic mutations in pulmonary arterial hypertension Garcia-Rivas, Gerardo; Jerjes-Sánchez, Carlos; Rodriguez, David BMC Medical Genetics, Vol. 18, Issue 1 https://doi.org/10.1186/s12881-017-0440-5	journal	August 2017
Pulmonary arterial hypertension: pathogenesis and clinical management Thenappan, Thenappan; Ormiston, Mark L.; Ryan, John J. BMJ https://doi.org/10.1136/bmj.j5492	journal	March 2018
The Search for Disease-Modifying Therapies in Pulmonary Hypertension Woodcock, Chen-Shan Chen; Chan, Stephen Y. Journal of Cardiovascular Pharmacology and Therapeutics, Vol. 24, Issue 4 https://doi.org/10.1177/1074248419829172	journal	February 2019
BMP type II receptor as a therapeutic target in pulmonary arterial hypertension Orriols, Mar; Gomez-Puerto, Maria Catalina; ten Dijke, Peter Cellular and Molecular Life Sciences, Vol. 74, Issue 16 https://doi.org/10.1007/s00018-017-2510-4	journal	April 2017
Activins bind and signal via bone morphogenetic protein receptor type II (BMPR2) in immortalized gonadotrope-like cells Rejon, Carlis A.; Hancock, Mark A.; Li, Yining N. Cellular Signalling, Vol. 25, Issue 12 https://doi.org/10.1016/j.cellsig.2013.09.002	journal	December 2013
A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-β Family Receptors Greenwald, Jason; Vega, Mark E.; Allendorph, George P. Molecular Cell, Vol. 15, Issue 3 https://doi.org/10.1016/j.molcel.2004.07.011	journal	August 2004
Highly accurate protein structure prediction with AlphaFold Jumper, John; Evans, Richard; Pritzel, Alexander Nature https://doi.org/10.1038/s41586-021-03819-2	journal	July 2021
Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily Daopin, S.; Piez, K.; Ogawa, Y. Science, Vol. 257, Issue 5068 https://doi.org/10.1126/science.1631557	journal	July 1992
SuperPose: a simple server for sophisticated structural superposition Maiti, R.; Van Domselaar, G. H.; Zhang, H. Nucleic Acids Research, Vol. 32, Issue Web Server https://doi.org/10.1093/nar/gkh477	journal	July 2004
PROMALS3D: a tool for multiple protein sequence and structure alignments Pei, Jimin; Kim, Bong-Hyun; Grishin, Nick V. Nucleic Acids Research, Vol. 36, Issue 7 https://doi.org/10.1093/nar/gkn072	journal	February 2008
Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells Yu, Paul B.; Beppu, Hideyuki; Kawai, Noriko Journal of Biological Chemistry, Vol. 280, Issue 26 https://doi.org/10.1074/jbc.M502825200	journal	July 2005
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne Cell Communication and Signaling, Vol. 13, Issue 1 https://doi.org/10.1186/s12964-015-0104-z	journal	June 2015
Combinatorial Signal Perception in the BMP Pathway Antebi, Yaron E.; Linton, James M.; Klumpe, Heidi Cell, Vol. 170, Issue 6 https://doi.org/10.1016/j.cell.2017.08.015	journal	September 2017
The role of bone morphogenetic protein signaling in vascular calcification Yang, Peiran; Troncone, Luca; Augur, Zachary M. Bone, Vol. 141 https://doi.org/10.1016/j.bone.2020.115542	journal	December 2020
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth Castonguay, Roselyne; Werner, Eric D.; Matthews, Robert G. Journal of Biological Chemistry, Vol. 286, Issue 34 https://doi.org/10.1074/jbc.M111.260133	journal	July 2011
ACVR1 ^R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A Hatsell, Sarah J.; Idone, Vincent; Wolken, Dana M. Alessi Science Translational Medicine, Vol. 7, Issue 303 https://doi.org/10.1126/scitranslmed.aac4358	journal	September 2015
New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand–Receptor Interactions and Antagonist Activity Aykul, Senem; Martinez-Hackert, Erik Journal of Molecular Biology, Vol. 428, Issue 3 https://doi.org/10.1016/j.jmb.2016.01.011	journal	February 2016
Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis Aykul, Senem; Martinez-Hackert, Erik Analytical Biochemistry, Vol. 508 https://doi.org/10.1016/j.ab.2016.06.025	journal	September 2016
A gentle vapor-diffusion technique for cross-linking of protein crystals for cryocrystallography Lusty, Carol J. Journal of Applied Crystallography, Vol. 32, Issue 1 https://doi.org/10.1107/S002188989801053X	journal	February 1999
Phaser.MRage : automated molecular replacement Bunkóczi, Gábor; Echols, Nathaniel; McCoy, Airlie J. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 11 https://doi.org/10.1107/S0907444913022750	journal	October 2013
[20] Processing of X-ray diffraction data collected in oscillation mode Otwinowski, Zbyszek; Minor, Wladek Macromolecular Crystallography Part A, 307-326 https://doi.org/10.1016/S0076-6879(97)76066-X	book	January 1997
iMOSFLM : a new graphical interface for diffraction-image processing with MOSFLM Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444910048675	journal	March 2011
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix Liebschner, Dorothee; Afonine, Pavel V.; Baker, Matthew L. Acta Crystallographica Section D Structural Biology, Vol. 75, Issue 10 https://doi.org/10.1107/S2059798319011471	journal	October 2019
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Inference of Macromolecular Assemblies from Crystalline State Krissinel, Evgeny; Henrick, Kim Journal of Molecular Biology, Vol. 372, Issue 3 https://doi.org/10.1016/j.jmb.2007.05.022	journal	September 2007

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