Structures of activin ligand traps using natural sets of type I and type II TGF[beta] receptors

Goebel, Erich J.; Kattamuri, Chandramohan; Gipson, Gregory R.; Krishnan, Lavanya; Chavez, Moises; Czepnik, Magdalena; Maguire, Michelle C.; Grenha, Rosa; H?kansson, Maria; Logan, Derek T.; Grinberg, Asya V.; Sako, Dianne; Castonguay, Roselyne; Kumar, Ravindra; Thompson, Thomas B.

doi:10.1016/j.isci.2021.103590

Structures of activin ligand traps using natural sets of type I and type II TGF[beta] receptors

Journal Article · 01 January 2022 · iScience

DOI:https://doi.org/10.1016/j.isci.2021.103590· OSTI ID:1841198

Goebel, Erich J.; Kattamuri, Chandramohan; Gipson, Gregory R.; Krishnan, Lavanya; Chavez, Moises; Czepnik, Magdalena; Maguire, Michelle C.; Grenha, Rosa; H?kansson, Maria; Logan, Derek T.; Grinberg, Asya V.; Sako, Dianne; Castonguay, Roselyne; Kumar, Ravindra; Thompson, Thomas B.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1841198

Journal Information:: iScience, Vol. 25, Issue (21)

Country of Publication:: United States

Language:: ENGLISH

References (49)

Towards automated crystallographic structure refinement with phenix.refine Afonine, Pavel V.; Grosse-Kunstleve, Ralf W.; Echols, Nathaniel Acta Crystallographica Section D Biological Crystallography, Vol. 68, Issue 4 https://doi.org/10.1107/S0907444912001308	journal	March 2012
Structure of the ternary signaling complex of a TGF-beta superfamily member Allendorph, G. P.; Vale, W. W.; Choe, S. Proceedings of the National Academy of Sciences, Vol. 103, Issue 20 https://doi.org/10.1073/pnas.0602558103	journal	May 2006
Treatment of sporadic inclusion body myositis with bimagrumab Amato, A. A.; Sivakumar, K.; Goyal, N. Neurology, Vol. 83, Issue 24 https://doi.org/10.1212/WNL.0000000000001070	journal	November 2014
Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors Attisano, L. Cell, Vol. 75, Issue 4 https://doi.org/10.1016/0092-8674(93)90488-C	journal	November 1993
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop Aykul, Senem; Corpina, Richard A.; Goebel, Erich J. eLife, Vol. 9 https://doi.org/10.7554/eLife.54582	journal	June 2020
Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies Badarau, Adriana; Rouha, Harald; Malafa, Stefan mAbs, Vol. 8, Issue 7 https://doi.org/10.1080/19420862.2016.1215791	journal	July 2016
Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type Cadena, Samuel M.; Tomkinson, Kathleen N.; Monnell, Travis E. Journal of Applied Physiology, Vol. 109, Issue 3 https://doi.org/10.1152/japplphysiol.00866.2009	journal	September 2010
The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding Cash, Jennifer N.; Rejon, Carlis A.; McPherron, Alexandra C. The EMBO Journal, Vol. 28, Issue 17 https://doi.org/10.1038/emboj.2009.205	journal	July 2009
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
How good are my data and what is the resolution? Evans, Philip R.; Murshudov, Garib N. Acta Crystallographica Section D Biological Crystallography, Vol. 69, Issue 7 https://doi.org/10.1107/S0907444913000061	journal	June 2013
Structural biology of the TGFβ family Goebel, Erich J.; Hart, Kaitlin N.; McCoy, Jason C. Experimental Biology and Medicine, Vol. 244, Issue 17 https://doi.org/10.1177/1535370219880894	journal	October 2019
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity Goebel, Erich J.; Corpina, Richard A.; Hinck, Cynthia S. Proceedings of the National Academy of Sciences, Vol. 116, Issue 31 https://doi.org/10.1073/pnas.1906253116	journal	July 2019
A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-β Family Receptors Greenwald, Jason; Vega, Mark E.; Allendorph, George P. Molecular Cell, Vol. 15, Issue 3 https://doi.org/10.1016/j.molcel.2004.07.011	journal	August 2004
Cooperative Assembly of TGF-β Superfamily Signaling Complexes Is Mediated by Two Disparate Mechanisms and Distinct Modes of Receptor Binding Groppe, Jay; Hinck, Cynthia S.; Samavarchi-Tehrani, Payman Molecular Cell, Vol. 29, Issue 2 https://doi.org/10.1016/j.molcel.2007.11.039	journal	February 2008
Structural basis for the inhibition of activin signalling by follistatin Harrington, Adrian E.; Morris-Triggs, Samantha A.; Ruotolo, Brandon T. The EMBO Journal, Vol. 25, Issue 5 https://doi.org/10.1038/sj.emboj.7601000	journal	February 2006
Identification of a Functional Binding Site for Activin on the Type I Receptor ALK4 Harrison, Craig A.; Gray, Peter C.; Koerber, Steven C. Journal of Biological Chemistry, Vol. 278, Issue 23 https://doi.org/10.1074/jbc.M302015200	journal	June 2003
Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily Hinck, Andrew P. FEBS Letters, Vol. 586, Issue 14 https://doi.org/10.1016/j.febslet.2012.05.028	journal	May 2012
Structural Biology and Evolution of the TGF-β Family Hinck, Andrew P.; Mueller, Thomas D.; Springer, Timothy A. Cold Spring Harbor Perspectives in Biology, Vol. 8, Issue 12 https://doi.org/10.1101/cshperspect.a022103	journal	September 2016
XDS Kabsch, Wolfgang Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2 https://doi.org/10.1107/S0907444909047337	journal	January 2010
The Solution Structure of BMPR-IA Reveals a Local Disorder-to-Order Transition upon BMP-2 Binding Klages, Jochen; Kotzsch, Alexander; Coles, Murray Biochemistry, Vol. 47, Issue 46 https://doi.org/10.1021/bi801059j	journal	October 2008
Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5–type I receptor specificity Kotzsch, Alexander; Nickel, Joachim; Seher, Axel The EMBO Journal, Vol. 28, Issue 7 https://doi.org/10.1038/emboj.2009.37	journal	February 2009
Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily Kumar, Ravindra; Grinberg, Asya V.; Li, Huiming Scientific Reports, Vol. 11, Issue 1 https://doi.org/10.1038/s41598-021-97203-9	journal	September 2021
An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy Lach-Trifilieff, Estelle; Minetti, Giulia C.; Sheppard, KellyAnn Molecular and Cellular Biology, Vol. 34, Issue 4 https://doi.org/10.1128/MCB.01307-13	journal	February 2014
Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice Latres, Esther; Pangilinan, Jeffrey; Miloscio, Lawrence Skeletal Muscle, Vol. 5, Issue 1 https://doi.org/10.1186/s13395-015-0060-8	journal	October 2015
Activin A more prominently regulates muscle mass in primates than does GDF8 Latres, Esther; Mastaitis, Jason; Fury, Wen Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms15153	journal	April 2017
ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders Li, Jia; Fredericks, Maureen; Cannell, Marishka Journal of Clinical Investigation, Vol. 131, Issue 4 https://doi.org/10.1172/JCI138634	journal	February 2021
Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches Mariot, Virginie; Joubert, Romain; Hourdé, Christophe Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-01486-4	journal	November 2017
Phaser crystallographic software McCoy, Airlie J.; Grosse-Kunstleve, Ralf W.; Adams, Paul D. Journal of Applied Crystallography, Vol. 40, Issue 4 https://doi.org/10.1107/S0021889807021206	journal	July 2007
Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy Morvan, Frederic; Rondeau, Jean-Michel; Zou, Chao Proceedings of the National Academy of Sciences, Vol. 114, Issue 47 https://doi.org/10.1073/pnas.1707925114	journal	November 2017
REFMAC 5 for the refinement of macromolecular crystal structures Murshudov, Garib N.; Skubák, Pavol; Lebedev, Andrey A. Acta Crystallographica Section D Biological Crystallography, Vol. 67, Issue 4 https://doi.org/10.1107/S0907444911001314	journal	March 2011
A Single Residue of GDF-5 Defines Binding Specificity to BMP Receptor IB Nickel, Joachim; Kotzsch, Alexander; Sebald, Walter Journal of Molecular Biology, Vol. 349, Issue 5 https://doi.org/10.1016/j.jmb.2005.04.015	journal	June 2005
Structural insights into the mechanism of action of a biparatopic anti-HER2 antibody Oganesyan, Vaheh; Peng, Li; Bee, Jared S. Journal of Biological Chemistry, Vol. 293, Issue 22 https://doi.org/10.1074/jbc.M117.818013	journal	June 2018
Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy Puolakkainen, Tero; Ma, Hongqian; Kainulainen, Heikki BMC Musculoskeletal Disorders, Vol. 18, Issue 1 https://doi.org/10.1186/s12891-016-1366-3	journal	January 2017
Ternary Complex of Transforming Growth Factor-β1 Reveals Isoform-specific Ligand Recognition and Receptor Recruitment in the Superfamily Radaev, Sergei; Zou, Zhongcheng; Huang, Tao Journal of Biological Chemistry, Vol. 285, Issue 19 https://doi.org/10.1074/jbc.M109.079921	journal	March 2010
Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB Sako, Dianne; Grinberg, Asya V.; Liu, June Journal of Biological Chemistry, Vol. 285, Issue 27 https://doi.org/10.1074/jbc.M110.114959	journal	April 2010
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms Salmon, Richard M.; Guo, Jingxu; Wood, Jennifer H. Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15425-3	journal	April 2020
Translational Pharmacokinetic/Pharmacodynamic Analysis of MYO-029 Antibody for Muscular Dystrophy: PK/PD Modeling of MYO-029 and Translation Singh, P.; Rong, H.; Gordi, T. Clinical and Translational Science, Vol. 9, Issue 6 https://doi.org/10.1111/cts.12420	journal	October 2016
The Structure of FSTL3·Activin A Complex Stamler, Robin; Keutmann, Henry T.; Sidis, Yisrael Journal of Biological Chemistry, Vol. 283, Issue 47 https://doi.org/10.1074/jbc.M801266200	journal	September 2008
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions Thompson, T. B. The EMBO Journal, Vol. 22, Issue 7 https://doi.org/10.1093/emboj/cdg156	journal	April 2003
The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding Thompson, Thomas B.; Lerch, Thomas F.; Cook, Robert W. Developmental Cell, Vol. 9, Issue 4 https://doi.org/10.1016/j.devcel.2005.09.008	journal	October 2005
Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex Townson, Sharon A.; Martinez-Hackert, Erik; Greppi, Chloe Journal of Biological Chemistry, Vol. 287, Issue 33 https://doi.org/10.1074/jbc.M112.377960	journal	June 2012
Structural basis for potency differences between GDF8 and GDF11 Walker, Ryan G.; Czepnik, Magdalena; Goebel, Erich J. BMC Biology, Vol. 15, Issue 1 https://doi.org/10.1186/s12915-017-0350-1	journal	March 2017
SWISS-MODEL: homology modelling of protein structures and complexes Waterhouse, Andrew; Bertoni, Martino; Bienert, Stefan Nucleic Acids Research, Vol. 46, Issue W1 https://doi.org/10.1093/nar/gky427	journal	May 2018
A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor Weber, Dionys; Kotzsch, Alexander; Nickel, Joachim BMC Structural Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1472-6807-7-6	journal	February 2007
The TGFbeta Superfamily Signaling Pathway: TGFbeta Superfamily Signaling Pathway Weiss, Alexander; Attisano, Liliana Wiley Interdisciplinary Reviews: Developmental Biology, Vol. 2, Issue 1 https://doi.org/10.1002/wdev.86	journal	October 2012
Mechanism of activation of the TGF-β receptor Wrana, Jeffrey L.; Attisano, Liliana; Wieser, Rotraud Nature, Vol. 370, Issue 6488 https://doi.org/10.1038/370341a0	journal	August 1994
Overexpression of human transforming growth factor-β1 using a recombinant CHO cell expression system Zou, Zhongcheng; Sun, Peter D. Protein Expression and Purification, Vol. 37, Issue 2 https://doi.org/10.1016/j.pep.2003.06.001	journal	October 2004
Assembly of TβRI:TβRII:TGFβ Ternary Complex in vitro with Receptor Extracellular Domains is Cooperative and Isoform-dependent Zúñiga, Jorge E.; Groppe, Jay C.; Cui, Yumin Journal of Molecular Biology, Vol. 354, Issue 5 https://doi.org/10.1016/j.jmb.2005.10.014	journal	December 2005
The T?R-I Pre-Helix Extension Is Structurally Ordered in the Unbound Form and Its Flanking Prolines Are Essential for Binding Zuniga, Jorge E.; Ilangovan, Udayar; Mahlawat, Pardeep Journal of Molecular Biology, Vol. 412, Issue 4 https://doi.org/10.1016/j.jmb.2011.07.046	journal	September 2011

Similar Records

THE 1.1 ANGSTROM CRYSTAL STRUCTURE OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND BINDING DOMAIN

Journal Article · 2002 · Structure · OSTI ID:15008676

BOESEN, C; RADAEV, S; MOTYKA, S; +2 more

CRYSTALLIZATION AND PRELIMINARY CRYSTALLOGRAPHIC STUDIES OF HUMAN TGF-BETA TYPE II RECEPTOR LIGAND-BINDING DOMAIN

Journal Article · 2002 · Acta Crystallographica Section D: Biological Crystallography · OSTI ID:15008677

BOESEN, C; MOTYKA, S; PATAMAWENU, A; +1 more

The genomic structure of the gene encoding the human transforming growth factor {beta} type II receptor (TGF-{beta} RII)

Journal Article · 1996 · Genomics · OSTI ID:486321

Takenoshita, Seiichi; Hagiwara, Koichi; Nagashima, Makoto; +1 more

Structures of activin ligand traps using natural sets of type I and type II TGF[beta] receptors

Citation Formats

References (49)

Similar Records

Related Subjects