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Electron emission from bromouracil and uracil induced by protons and radiosensitization

Journal Article · · New Journal of Physics
 [1];  [2];  [3];  [4];  [2];  [3]
  1. Tata Inst. of Fundamental Research, Mumbai (India); Synchrotron SOLEIL, St. Aubin (France)
  2. Univ. Nacional de Rosario (Argentina)
  3. Tata Inst. of Fundamental Research, Mumbai (India)
  4. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
+ Show Author Affiliations
Absolute double differential cross sections (DDCS) of electrons emitted from uracil and 5-bromouracil (BrU) in collisions with protons of energy 200 keV have been measured for various forward and backward emission angles over wide range of electron energies. The measured DDCS are compared with the continuum distorted wave-eikonal initial state (CDW-EIS) calculations. The optimized structure of the BrU was estimated along with the population analysis of all the occupied orbitals using a self-consistent field density. A comparison between the measured DDCS data for the two molecules show that the cross section of low energy electrons emitted from BrU is substantially larger than that for uracil. The BrU-to-uracil DDCS ratios obtained from the present measurements indicate an enhancement of the electron emission by a factor which is as large as 2.0 to 2.5. These electrons being the major agent for damaging the DNA/RNA of the malignant tissues, the present results are expected to provide an important input for the radiosensitization effect in hadron therapy. It is noteworthy to mention that the CDW-EIS calculations for Coulomb ionization cannot predict such enhancement. A large angular asymmetry is observed for uracil with a broad structure, which is absent in case of BrU.
Research Organization:
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
Government of India; USDOE National Nuclear Security Administration (NNSA)
Grant/Contract Number:
NA0003525
OSTI ID:
1877151
Report Number(s):
SAND2022-8623J; 707939
Journal Information:
New Journal of Physics, Journal Name: New Journal of Physics Journal Issue: 7 Vol. 24; ISSN 1367-2630
Publisher:
IOP PublishingCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS
CDW-EIS
double differential cross section
electron spectroscopy
forward-backward angular asymmetry
halouracils
radiosensitization