Epidermal Differential Impedance Sensor for Conformal Skin Hydration Monitoring

Huang, Xian; Yeo, Woon-Hong; Liu, Yuhao; Rogers, John A.

doi:10.1007/s13758-012-0052-8

Epidermal Differential Impedance Sensor for Conformal Skin Hydration Monitoring

Journal Article · Thu Aug 23 00:00:00 EDT 2012 · Biointerphases

DOI:https://doi.org/10.1007/s13758-012-0052-8· OSTI ID:1875150

Huang, Xian ^[1]; Yeo, Woon-Hong ^[2]; Liu, Yuhao ^[2]; Rogers, John A. ^[2]

Univ. of Illinois at Urbana-Champaign, IL (United States); University of Illinois
Univ. of Illinois at Urbana-Champaign, IL (United States)

We present the design and use of an ultrathin, stretchable sensor system capable of conformal lamination onto the skin, for precision measurement and spatial mapping of levels of hydration. This device, which we refer to as a class of ‘epidermal electronics’ due to its ‘skin-like’ construction and mode of intimate integration with the body, contains miniaturized arrays of impedance-measurement electrodes arranged in a differential configuration to compensate for common-mode disturbances. Experimental results obtained with different frequencies and sensor geometries demonstrate excellent precision and accuracy, as benchmarked against conventional, commercial devices. The reversible, non-invasive soft contact of this device with the skin makes its operation appealing for applications ranging from skin care, to athletic monitoring to health/wellness assessment.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-07ER46471; FG02-07ER46453

OSTI ID:: 1875150

Journal Information:: Biointerphases, Journal Name: Biointerphases Journal Issue: 1 Vol. 7; ISSN 1934-8630

Publisher:: American Institute of Physics (AIP)Copyright Statement

Country of Publication:: United States

Language:: English

References (33)

Near-IR spectroscopic imaging for skin hydration: The long and the short of it Attas, E. Michael; Sowa, Michael G.; Posthumus, Trevor B. Biopolymers, Vol. 67, Issue 2, p. 96-106 https://doi.org/10.1002/bip.10056	journal	January 2002
Hydration Effects on Skin Microstructure as Probed by High-Resolution Cryo-Scanning Electron Microscopy and Mechanistic Implications to Enhanced Transcutaneous Delivery of Biomacromolecules Tan, Grace; Xu, Peng; Lawson, Louise B. Journal of Pharmaceutical Sciences, Vol. 99, Issue 2, p. 730-740 https://doi.org/10.1002/jps.21863	journal	February 2010
Electrical properties of the epidermal stratum corneum Yamamoto, Tatsuma; Yamamoto, Yoshitake Medical & Biological Engineering, Vol. 14, Issue 2, p. 151-158 https://doi.org/10.1007/BF02478741	journal	March 1976
Water: An Essential But Overlooked Nutrient Kleiner, Susan M. Journal of the American Dietetic Association, Vol. 99, Issue 2, p. 200-206 https://doi.org/10.1016/S0002-8223(99)00048-6	journal	February 1999
Suppressing harmonic powerline interference using multiple-notch filtering methods with improved transient behavior Piskorowski, Jacek Measurement, Vol. 45, Issue 6, p. 1350-1361 https://doi.org/10.1016/j.measurement.2012.03.004	journal	July 2012
A Multidisciplinary Approach to Evaluation and Treatment of Atopic Dermatitis Boguniewicz, Mark; Nicol, Noreen; Kelsay, Kim Seminars in Cutaneous Medicine and Surgery, Vol. 27, Issue 2, p. 115-127 https://doi.org/10.1016/j.sder.2008.05.001	journal	June 2008
Use of Cutometer to assess epidermal hydration Dobrev, Hristo Skin Research and Technology, Vol. 6, Issue 4, p. 239-244 https://doi.org/10.1034/j.1600-0846.2000.006004239.x	journal	November 2000
Influence of heat-stress induced dehydration on mental functions Sharma, V. M.; Sridharan, K.; Pichan, G. Ergonomics, Vol. 29, Issue 6, p. 791-799 https://doi.org/10.1080/00140138608968315	journal	June 1986
The dielectric properties of biological tissues: I. Literature survey Gabriel, C.; Gabriel, S.; Corthout, E. Physics in Medicine and Biology, Vol. 41, Issue 11, p. 2231-2249 https://doi.org/10.1088/0031-9155/41/11/001	journal	November 1996
A quantitative approach to the dielectric properties of the skin Raicu, Valerica; Kitagawa, Nobuko; Irimajiri, Akihiko Physics in Medicine and Biology, Vol. 45, Issue 2, p. L1-L4 https://doi.org/10.1088/0031-9155/45/2/101	journal	December 1999
Measurement of the electrical properties of human skin and the variation among subjects with certain skin conditions Sunaga, Takahiro; Ikehira, Hiroo; Furukawa, Shigeo Physics in Medicine and Biology, Vol. 47, Issue 1, p. N11-N15 https://doi.org/10.1088/0031-9155/47/1/402	journal	November 2001
Assessing skin hydration status in haemodialysis patients using terahertz spectroscopy: a pilot/feasibility study Kadlec, Filip; Berta, Milan; Kužel, Petr Physics in Medicine and Biology, Vol. 53, Issue 24, p. 7063-7071 https://doi.org/10.1088/0031-9155/53/24/004	journal	November 2008
Electrical conductivity of tissue at frequencies below 1 MHz Gabriel, C.; Peyman, A.; Grant, E. H. Physics in Medicine and Biology, Vol. 54, Issue 16, p. 4863-4878 https://doi.org/10.1088/0031-9155/54/16/002	journal	July 2009
Method and device for bio-impedance measurement with hard-tissue applications Guimerà, A.; Calderón, E.; Los, P. Physiological Measurement, Vol. 29, Issue 6, p. S279-S290 https://doi.org/10.1088/0967-3334/29/6/S24	journal	June 2008
Opto-thermal in-vivo skin hydration measurements – a comparison study of different measurement techniques Xiao, P.; Ciortea, L. I.; Singh, H. Journal of Physics: Conference Series, Vol. 214, Article No. 012026 https://doi.org/10.1088/1742-6596/214/1/012026	journal	March 2010
Influence of epidermal hydration on the friction of human skin against textiles Gerhardt, L.-C.; Strassle, V.; Lenz, A. Journal of The Royal Society Interface, Vol. 5, Issue 28, p. 1317-1328 https://doi.org/10.1098/rsif.2008.0034	journal	November 2008
Interdigital sensors and transducers Mamishev, A. V.; Sundara-Rajan, K. Proceedings of the IEEE, Vol. 92, Issue 5, p. 808-845 https://doi.org/10.1109/JPROC.2004.826603	journal	May 2004
Biomechanical Properties of In Vivo Human Skin From Dynamic Optical Coherence Elastography Liang, Xing; Boppart, Stephen A. IEEE Transactions on Biomedical Engineering, Vol. 57, Issue 4, p. 953-959 https://doi.org/10.1109/TBME.2009.2033464	journal	April 2010
Evaluation of the Skin Surface Hydration in Vivo by Electrical Measurement Tagami, Hachiro; Ohi, Masatoshi; Iwatsuki, Keiji Journal of Investigative Dermatology, Vol. 75, Issue 6, p. 500-507 https://doi.org/10.1111/1523-1747.ep12524316	journal	December 1980
Skin hydration: a review on its molecular mechanisms Verdier-Sévrain, Sylvie; Bonté, Frédéric Journal of Cosmetic Dermatology, Vol. 6, Issue 2, p. 75-82 https://doi.org/10.1111/j.1473-2165.2007.00300.x	journal	June 2007
Hydration studies on scaly hand eczema Blichmann, Christa; Serup, Jørgen Contact Dermatitis, Vol. 16, Issue 3, p. 155-159 https://doi.org/10.1111/j.1600-0536.1987.tb01411.x	journal	March 1987
Corneometiy measurements to evaluate skin dryness in the modified soap chamber test Paye, M.; Gaer, D.; Morrison, B. M. Skin Research and Technology, Vol. 1, Issue 3, p. 123-127 https://doi.org/10.1111/j.1600-0846.1995.tb00031.x	journal	August 1995
High-frequency conductance measurement of the skin surface hydration state of dry skin using a new probe studded with needle-form electrodes (MT-8C) Sasai, Shu; Zhen, Ya-Xian; Tagami, Hachiro Skin Research and Technology, Vol. 2, Issue 4, p. 173-176 https://doi.org/10.1111/j.1600-0846.1996.tb00146.x	journal	November 1996
In vitro calibration of the capacitance method (Corneometer CM 825) and conductance method (Skicon-200) for the evaluation of the hydration state of the skin Barel, André O.; Clarys, Peter Skin Research and Technology, Vol. 3, Issue 2, p. 107-113 https://doi.org/10.1111/j.1600-0846.1997.tb00171.x	journal	May 1997
Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part I. In vitro Fluhr, Joachim W.; Gloor, Max; Lazzerini, Sabrina Skin Research and Technology, Vol. 5, Issue 3, p. 161-170 https://doi.org/10.1111/j.1600-0846.1999.tb00126.x	journal	August 1999
Comparative study of five instruments measuring stratum corneum hydration (Corneometer CM 820 and CM 825, Skicon 200, Nova DPM 9003, DermaLab). Part II. In vivo Fluhr, Joachim W.; Gloor, Max; Lazzerini, Sabrina Skin Research and Technology, Vol. 5, Issue 3, p. 171-178 https://doi.org/10.1111/j.1600-0846.1999.tb00127.x	journal	August 1999
Measuring depth depends on frequency in electrical skin impedance measurements Martinsen, ØSrjan G.; Grimnes, Sverre; Haug, Erlend Skin Research and Technology, Vol. 5, Issue 3, p. 179-181 https://doi.org/10.1111/j.1600-0846.1999.tb00128.x	journal	August 1999
Non-invasive electrical measurements for the evaluation of the hydration state of the skin: comparison between three conventional instruments - the Comeometer®, the Skicon® and the Nova DPM® Clarys, Peter; Barel, André O.; Gabard, B. Skin Research and Technology, Vol. 5, Issue 1, p. 14-20 https://doi.org/10.1111/j.1600-0846.1999.tb00198.x	journal	February 1999
Measurement of hydration in the stratum corneum with the MoistureMeter and comparison with the Corneometer Alanen, Esko; Nuutinen, Jouni; Nicklen, Kirsi Skin Research and Technology, Vol. 10, Issue 1, p. 32-37 https://doi.org/10.1111/j.1600-0846.2004.00050.x	journal	February 2004
Influence of hydration and experimental length scale on the mechanical response of human skin in vivo, using optical coherence tomography Hendriks, F. M.; Brokken, D.; Oomens, C. W. J. Skin Research and Technology, Vol. 10, Issue 4, p. 231-241 https://doi.org/10.1111/j.1600-0846.2004.00077.x	journal	November 2004
Millimeter wave reflectivity used for measurement of skin hydration with different moisturizers Alekseev, S. I.; Szabo, I.; Ziskin, M. C. Skin Research and Technology, Vol. 14, Issue 4, p. 390-396 https://doi.org/10.1111/j.1600-0846.2008.00319.x	journal	November 2008
Epidermal Electronics Kim, D.-H.; Lu, N.; Ma, R. Science, Vol. 333, Issue 6044, p. 838-843 https://doi.org/10.1126/science.1206157	journal	August 2011
Bioimpedance measurements of human body composition: critical analysis and outlook Matthie, James R. Expert Review of Medical Devices, Vol. 5, Issue 2, p. 239-261 https://doi.org/10.1586/17434440.5.2.239	journal	March 2008

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