Conformal piezoelectric systems for clinical and experimental characterization of soft tissue biomechanics

Dagdeviren, Canan; Shi, Yan; Joe, Pauline; Ghaffari, Roozbeh; Balooch, Guive; Usgaonkar, Karan; Gur, Onur; Tran, Phat L.; Crosby, Jessi R.; Meyer, Marcin; Su, Yewang; Chad Webb, R.; Tedesco, Andrew S.; Slepian, Marvin J.; Huang, Yonggang; Rogers, John A.

doi:10.1038/nmat4289

Title: Conformal piezoelectric systems for clinical and experimental characterization of soft tissue biomechanics

Journal Article · Mon May 18 00:00:00 EDT 2015 · Nature Materials

DOI:https://doi.org/10.1038/nmat4289· OSTI ID:1875110

Dagdeviren, Canan ^[1]; Shi, Yan ^[2]; Joe, Pauline ^[1]; Ghaffari, Roozbeh ^[3]; Balooch, Guive ^[4]; Usgaonkar, Karan ^[1]; Gur, Onur ^[1]; Tran, Phat L. ^[5]; Crosby, Jessi R. ^[5]; Meyer, Marcin ^[6]; Su, Yewang ^[7]; Chad Webb, R. ^[1]; Tedesco, Andrew S. ^[8]; Slepian, Marvin J. ^[5]; Huang, Yonggang ^[9]; Rogers, John A. ^[1]

Univ. of Illinois at Urbana-Champaign, IL (United States)
Nanjing Univ. of Aeronautics & Astronautics (China); Northwestern Univ., Evanston, IL (United States)
MC10 Inc., Cambridge, MA (United States)
L’Oreal R&I Incubator, Clark, NJ (United States)
Univ. of Arizona, Tucson, AZ (United States)
TU Dresden (Germany)
Northwestern Univ., Evanston, IL (United States); Tsinghua Univ., Beijing (China)
Academy Dermatologist Group Ltd, Tucson, AZ (United States)
Northwestern Univ., Evanston, IL (United States)

Mechanical assessment of soft biological tissues and organs has broad relevance in clinical diagnosis and treatment of disease. Existing characterization methods are invasive, lack microscale spatial resolution, and are tailored only for specific regions of the body under quasi-static conditions. Here, we develop conformal and piezoelectric devices that enable in vivo measurements of soft tissue viscoelasticity in the near-surface regions of the epidermis. Furthermore, these systems achieve conformal contact with the underlying complex topography and texture of the targeted skin, as well as other organ surfaces, under both quasi-static and dynamic conditions. Experimental and theoretical characterization of the responses of piezoelectric actuator–sensor pairs laminated on a variety of soft biological tissues and organ systems in animal models provide information on the operation of the devices. Studies on human subjects establish the clinical significance of these devices for rapid and non-invasive characterization of skin mechanical properties.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-07ER46471

OSTI ID:: 1875110

Journal Information:: Nature Materials, Vol. 14, Issue 7; ISSN 1476-1122

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

References (41)

Service life estimation of liquid silicone rubber seals in polymer electrolyte membrane fuel cell environment Cui, Tong; Lin, C. -W.; Chien, C. H. Journal of Power Sources, Vol. 196, Issue 3 https://doi.org/10.1016/j.jpowsour.2010.08.075	journal	February 2011
Variations with age in the mechanical properties of human skin in vivo Alexander, H.; Cook, T. Journal of Tissue Viability, Vol. 16, Issue 3 https://doi.org/10.1016/S0965-206X(06)63002-7	journal	August 2006
Age-dependent biomechanical properties of the skin Pawlaczyk, Mariola; Lelonkiewicz, Monika; Wieczorowski, Michał Advances in Dermatology and Allergology, Vol. 5 https://doi.org/10.5114/pdia.2013.38359	journal	January 2013
Structure and function of the stratum corneum permeability barrier Elias, Peter M. Drug Development Research, Vol. 13, Issue 2-3 https://doi.org/10.1002/ddr.430130203	journal	January 1988
Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring Dagdeviren, Canan; Su, Yewang; Joe, Pauline Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms5496	journal	August 2014
Influence of age and regional differences on skin elasticity as measured by the Cutometer Ryu, Hyo Sub; Joo, Young Hyun; Kim, Sun Ok Skin Research and Technology, Vol. 14, Issue 3 https://doi.org/10.1111/j.1600-0846.2008.00302.x	journal	August 2008
Transient, Biocompatible Electronics and Energy Harvesters Based on ZnO Dagdeviren, Canan; Hwang, Suk-Won; Su, Yewang Small, Vol. 9, Issue 20 https://doi.org/10.1002/smll.201300146	journal	April 2013
Cell Mechanics Using Atomic Force Microscopy-Based Single-Cell Compression Lulevich, Valentin; Zink, Tiffany; Chen, Huan-Yuan Langmuir, Vol. 22, Issue 19 https://doi.org/10.1021/la060561p	journal	July 2006
In vivo Biophysical Characterization of Skin Physiological Differences in Races Berardesca, E.; de Rigal, J.; Leveque, J. L. Dermatology, Vol. 182, Issue 2 https://doi.org/10.1159/000247752	journal	January 1991
Design of gas separation membranes derived of rigid aromatic polyimides. 1. Polymers from diamines containing di-tert-butyl side groups Calle, Mariola; Lozano, Angel E.; de Abajo, Javier Journal of Membrane Science, Vol. 365, Issue 1-2 https://doi.org/10.1016/j.memsci.2010.08.051	journal	December 2010
Tensional homeostasis and the malignant phenotype Paszek, Matthew J.; Zahir, Nastaran; Johnson, Kandice R. Cancer Cell, Vol. 8, Issue 3 https://doi.org/10.1016/j.ccr.2005.08.010	journal	September 2005
A numerical-experimental method to characterize the non-linear mechanical behaviour of human skin: Non-linear mechanical behaviour of human skin Hendriks, F. M.; Brokken, D.; Van Eemeren, J. T. W. M. Skin Research and Technology, Vol. 9, Issue 3 https://doi.org/10.1034/j.1600-0846.2003.00019.x	journal	July 2003
Method for characterizing viscoelasticity of human gluteal tissue Then, C.; Vogl, T. J.; Silber, G. Journal of Biomechanics, Vol. 45, Issue 7 https://doi.org/10.1016/j.jbiomech.2012.01.037	journal	April 2012
Three-dimensional analyses of individual corneocytes with atomic force microscope: morphological changes related to age, location and to the pathologic skin conditions Kashibuchi, Nobuo; Hirai, Yoshikazu; O'Goshi, Kenichiro Skin Research and Technology, Vol. 8, Issue 4 https://doi.org/10.1034/j.1600-0846.2002.00348.x	journal	November 2002
A Viscoelastic Model for the Rate Effect in Transfer Printing Cheng, H.; Li, M.; Wu, J. Journal of Applied Mechanics, Vol. 80, Issue 4 https://doi.org/10.1115/1.4007851	journal	May 2013
Critical review of analysis and interpretation of nanoindentation test data Fischer-Cripps, A. C. Surface and Coatings Technology, Vol. 200, Issue 14-15 https://doi.org/10.1016/j.surfcoat.2005.03.018	journal	April 2006
Viscoelastic properties of young and old human dermis: A proposed molecular mechanism for elastic energy storage in collagen and elastin Silver, Frederick H.; Seehra, Gurinder P.; Freeman, Joseph W. Journal of Applied Polymer Science, Vol. 86, Issue 8 https://doi.org/10.1002/app.11119	journal	September 2002
TGF- regulates the mechanical properties and composition of bone matrix Balooch, G.; Balooch, M.; Nalla, R. K. Proceedings of the National Academy of Sciences, Vol. 102, Issue 52 https://doi.org/10.1073/pnas.0507417102	journal	December 2005
Sex- and site-dependent variations in the thickness and mechanical properties of human skin in vivo Diridollou, S.; Black, D.; Lagarde, J. M. International Journal of Cosmetic Science, Vol. 22, Issue 6 https://doi.org/10.1111/j.1468-2494.2000.00037.x	journal	December 2000
Torsional elasticity of human skin in vivo Sanders, R. Pfl�gers Archiv European Journal of Physiology, Vol. 342, Issue 3 https://doi.org/10.1007/BF00591373	journal	January 1973
Mechanisms of sensory transduction in the skin Lumpkin, Ellen A.; Caterina, Michael J. Nature, Vol. 445, Issue 7130 https://doi.org/10.1038/nature05662	journal	February 2007
Age-related mechanical properties of human skin: An in vivo study Escoffier, Catherine; de Rigal, Jean; Rochefort, Annie Journal of Investigative Dermatology, Vol. 93, Issue 3 https://doi.org/10.1016/0022-202X(89)90058-4	journal	September 1989
Assessment of elastic parameters of human skin using dynamic elastography Gennisson, J. -L.; Baldeweck, T.; Tanter, M. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 51, Issue 8 https://doi.org/10.1109/TUFFC.2004.1324402	journal	August 2004
Viscoelastic mechanical behavior of soft microcantilever-based force sensors Lin, I-Kuan; Liao, Yen-Ming; Liu, Yan Applied Physics Letters, Vol. 93, Issue 25 https://doi.org/10.1063/1.3056114	journal	December 2008
In vivo model of the mechanical properties of the human skin under suction: Model of skin mechanical properties Diridollou, S.; Patat, F.; Gens, F. Skin Research and Technology, Vol. 6, Issue 4 https://doi.org/10.1034/j.1600-0846.2000.006004214.x	journal	November 2000
Skin Blood Flow in Adult Human Thermoregulation: How It Works, When It Does Not, and Why Charkoudian, Nisha Mayo Clinic Proceedings, Vol. 78, Issue 5 https://doi.org/10.4065/78.5.603	journal	May 2003
Age-Related Mechanical Properties of Human Skin: An In Vivo Study. Escoffier, Catherine; de Rigal, Jean; Rochefort, Annie Journal of Investigative Dermatology, Vol. 93, Issue 3 https://doi.org/10.1111/1523-1747.ep12280259	journal	September 1989
Influence of ageing on the in vivo extensibility of human skin at a low stress Leveque, J. L.; de Rigal, J.; Agache, P. G. Archives of Dermatological Research, Vol. 269, Issue 2 https://doi.org/10.1007/BF00406532	journal	November 1980
Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells Xu, Wenwei; Mezencev, Roman; Kim, Byungkyu PLoS ONE, Vol. 7, Issue 10 https://doi.org/10.1371/journal.pone.0046609	journal	October 2012
Investigation of the swelling of human skin cells in liquid media by tapping mode scanning force microscopy Richter, T.; Müller, J. H.; Schwarz, U. D. Applied Physics A, Vol. 72, Issue S1 https://doi.org/10.1007/s003390100750	journal	March 2001
Myocardial fiber architecture of the human heart ventricles Fernandez-Teran, M. A.; Hurle, J. M. The Anatomical Record, Vol. 204, Issue 2 https://doi.org/10.1002/ar.1092040207	journal	October 1982
Directional variations in the extensibility of human skin Stark, H. L. British Journal of Plastic Surgery, Vol. 30, Issue 2 https://doi.org/10.1016/0007-1226(77)90001-7	journal	April 1977
Determining elastic properties of skin by measuring surface waves from an impulse mechanical stimulus using phase-sensitive optical coherence tomography Li, Chunhui; Guan, Guangying; Reif, Roberto Journal of The Royal Society Interface, Vol. 9, Issue 70 https://doi.org/10.1098/rsif.2011.0583	journal	November 2011
Mechanical Function of the Skin: State of the Art Barel, A. O.; Lambrecht, R.; Clarys, P. Current Problems in Dermatology https://doi.org/10.1159/000060577	book	January 1998
Piezoelectric nanoribbons for monitoring cellular deformations Nguyen, Thanh D.; Deshmukh, Nikhil; Nagarah, John M. Nature Nanotechnology, Vol. 7, Issue 9 https://doi.org/10.1038/nnano.2012.112	journal	July 2012
Conformal piezoelectric energy harvesting and storage from motions of the heart, lung, and diaphragm Dagdeviren, Canan; Yang, Byung Duk; Su, Yewang Proceedings of the National Academy of Sciences, Vol. 111, Issue 5, p. 1927-1932 https://doi.org/10.1073/pnas.1317233111	journal	January 2014
The extensibility in human skin: variation according to age and site Sugihara, T.; Ohura, T.; Homma, K. British Journal of Plastic Surgery, Vol. 44, Issue 6 https://doi.org/10.1016/0007-1226(91)90199-T	journal	January 1991
A computational skin model: fold and wrinkle formation Magnenat-Thalmann, N.; Kalra, P.; Luc Leveque, J. IEEE Transactions on Information Technology in Biomedicine, Vol. 6, Issue 4 https://doi.org/10.1109/TITB.2002.806097	journal	December 2002
Influence of age on the wrinkling capacities of skin: Influence of age on the wrinkling capacities of the skin Batisse, Dominique; Bazin, Roland; Baldeweck, Thérèse Skin Research and Technology, Vol. 8, Issue 3 https://doi.org/10.1034/j.1600-0846.2002.10308.x	journal	August 2002
The Influence of Ageing on the in vivo Elasticity of Human Skin Grahame, R.; Holt, P. J. L. Gerontology, Vol. 15, Issue 2-3 https://doi.org/10.1159/000211681	journal	January 1969
Examination of Stratum Corneum Barrier Function In Vivo by Infrared Spectroscopy Bommannan, D.; Potts, Russell O.; Guy, Richard H. Journal of Investigative Dermatology, Vol. 95, Issue 4 https://doi.org/10.1111/1523-1747.ep12555503	journal	October 1990

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Mogul-Patterned Elastomeric Substrate for Stretchable Electronics Lee, Han-Byeol; Bae, Chan-Wool; Duy, Le Thai Advanced Materials, Vol. 28, Issue 16 https://doi.org/10.1002/adma.201505218	journal	February 2016
Modular and Reconfigurable Wireless E‐Tattoos for Personalized Sensing Jeong, Hyoyoung; Wang, Liu; Ha, Taewoo Advanced Materials Technologies, Vol. 4, Issue 8 https://doi.org/10.1002/admt.201900117	journal	May 2019
Carbon nanotube-based flexible electronics Xiang, Li; Zhang, Heng; Hu, Youfan Journal of Materials Chemistry C, Vol. 6, Issue 29 https://doi.org/10.1039/c8tc02280a	journal	January 2018
Blending Electronics with the Human Body: A Pathway toward a Cybernetic Future Mehrali, Mehdi; Bagherifard, Sara; Akbari, Mohsen Advanced Science, Vol. 5, Issue 10 https://doi.org/10.1002/advs.201700931	journal	August 2018
Piezo-catalysis for nondestructive tooth whitening Wang, Yang; Wen, Xinrong; Jia, Yanmin Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-15015-3	journal	March 2020
Conformal transistor arrays based on solution-processed organic crystals Zhao, Xiaoli; Zhang, Bing; Tang, Qingxin Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-15518-y	journal	November 2017
Highly flexible, wearable, and disposable cardiac biosensors for remote and ambulatory monitoring Lee, Stephen P.; Ha, Grace; Wright, Don E. npj Digital Medicine, Vol. 1, Issue 1 https://doi.org/10.1038/s41746-017-0009-x	journal	January 2018
Intraoperative monitoring of neuromuscular function with soft, skin-mounted wireless devices Liu, Yuhao; Tian, Limei; Raj, Milan S. npj Digital Medicine, Vol. 1, Issue 1 https://doi.org/10.1038/s41746-018-0023-7	journal	May 2018
Electrolyte-Sensing Transistor Decals Enabled by Ultrathin Microbial Nanocellulose Yuen, Jonathan D.; Walper, Scott A.; Melde, Brian J. Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/srep40867	journal	January 2017

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