Conformal piezoelectric systems for clinical and experimental characterization of soft tissue biomechanics

Dagdeviren, Canan; Shi, Yan; Joe, Pauline; Ghaffari, Roozbeh; Balooch, Guive; Usgaonkar, Karan; Gur, Onur; Tran, Phat L.; Crosby, Jessi R.; Meyer, Marcin; Su, Yewang; Chad Webb, R.; Tedesco, Andrew S.; Slepian, Marvin J.; Huang, Yonggang; Rogers, John A.

doi:10.1038/nmat4289

Conformal piezoelectric systems for clinical and experimental characterization of soft tissue biomechanics

Journal Article · Mon May 18 00:00:00 EDT 2015 · Nature Materials

DOI:https://doi.org/10.1038/nmat4289· OSTI ID:1875110

Dagdeviren, Canan ^[1]; Shi, Yan ^[2]; Joe, Pauline ^[3]; Ghaffari, Roozbeh ^[4]; Balooch, Guive ^[5]; Usgaonkar, Karan ^[3]; Gur, Onur ^[3]; Tran, Phat L. ^[6]; Crosby, Jessi R. ^[6]; Meyer, Marcin ^[7]; Su, Yewang ^[8]; Chad Webb, R. ^[3]; Tedesco, Andrew S. ^[9]; Slepian, Marvin J. ^[6]; Huang, Yonggang ^[10]; Rogers, John A. ^[3]

Univ. of Illinois at Urbana-Champaign, IL (United States); University of Illinois
Nanjing Univ. of Aeronautics & Astronautics (China); Northwestern Univ., Evanston, IL (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States)
MC10 Inc., Cambridge, MA (United States)
L’Oreal R&I Incubator, Clark, NJ (United States)
Univ. of Arizona, Tucson, AZ (United States)
TU Dresden (Germany)
Northwestern Univ., Evanston, IL (United States); Tsinghua Univ., Beijing (China)
Academy Dermatologist Group Ltd, Tucson, AZ (United States)
Northwestern Univ., Evanston, IL (United States)

Mechanical assessment of soft biological tissues and organs has broad relevance in clinical diagnosis and treatment of disease. Existing characterization methods are invasive, lack microscale spatial resolution, and are tailored only for specific regions of the body under quasi-static conditions. Here, we develop conformal and piezoelectric devices that enable in vivo measurements of soft tissue viscoelasticity in the near-surface regions of the epidermis. Furthermore, these systems achieve conformal contact with the underlying complex topography and texture of the targeted skin, as well as other organ surfaces, under both quasi-static and dynamic conditions. Experimental and theoretical characterization of the responses of piezoelectric actuator–sensor pairs laminated on a variety of soft biological tissues and organ systems in animal models provide information on the operation of the devices. Studies on human subjects establish the clinical significance of these devices for rapid and non-invasive characterization of skin mechanical properties.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division

Grant/Contract Number:: FG02-07ER46471

OSTI ID:: 1875110

Journal Information:: Nature Materials, Journal Name: Nature Materials Journal Issue: 7 Vol. 14; ISSN 1476-1122

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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Rubbery electronics and sensors from intrinsically stretchable elastomeric composites of semiconductors and conductors Kim, Hae-Jin; Sim, Kyoseung; Thukral, Anish Science Advances, Vol. 3, Issue 9 https://doi.org/10.1126/sciadv.1701114	journal	September 2017
Fully rubbery integrated electronics from high effective mobility intrinsically stretchable semiconductors Sim, Kyoseung; Rao, Zhoulyu; Kim, Hae-Jin Science Advances, Vol. 5, Issue 2 https://doi.org/10.1126/sciadv.aav5749	journal	February 2019
Miniaturized neural system for chronic, local intracerebral drug delivery Dagdeviren, Canan; Ramadi, Khalil B.; Joe, Pauline Science Translational Medicine, Vol. 10, Issue 425 https://doi.org/10.1126/scitranslmed.aan2742	journal	January 2018
Epidermal electronics for noninvasive, wireless, quantitative assessment of ventricular shunt function in patients with hydrocephalus Krishnan, Siddharth R.; Ray, Tyler R.; Ayer, Amit B. Science Translational Medicine, Vol. 10, Issue 465 https://doi.org/10.1126/scitranslmed.aat8437	journal	October 2018
Relevance of Indentation Test to Characterize Soft Biological Tissue: Application to Human Skin Azzez, Khouloud; Chaabane, Makram; Abellan, Marie-Angele International Journal of Applied Mechanics, Vol. 10, Issue 07 https://doi.org/10.1142/s1758825118500746	journal	August 2018
Review—Energy Autonomous Wearable Sensors for Smart Healthcare: A Review Dahiya, Abhishek Singh; Thireau, Jerome; Boudaden, Jamila Journal of The Electrochemical Society, Vol. 167, Issue 3 https://doi.org/10.1149/2.0162003jes	journal	January 2020
Mini Review on Flexible and Wearable Electronics for Monitoring Human Health Information Gu, Yiding; Zhang, Ting; Chen, Hao Nanoscale Research Letters, Vol. 14, Issue 1 https://doi.org/10.1186/s11671-019-3084-x	journal	August 2019
Use of flexible sensor to characterize biomechanics of canine skin Downey, Austin R. J.; Yan, Jin; Zellner, Eric M. BMC Veterinary Research, Vol. 15, Issue 1 https://doi.org/10.1186/s12917-018-1755-y	journal	January 2019
Wearables and the medical revolution Dunn, Jessilyn; Runge, Ryan; Snyder, Michael Personalized Medicine, Vol. 15, Issue 5 https://doi.org/10.2217/pme-2018-0044	journal	September 2018
FEP Encapsulated Crack-Based Sensor for Measurement in Moisture-Laden Environment Kim, Minho; Choi, Hyesu; Kim, Taewi Materials, Vol. 12, Issue 9 https://doi.org/10.3390/ma12091516	journal	May 2019

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