A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings

Escabí, Monty A.; Read, Heather L.; Viventi, Jonathan; Kim, Dae-Hyeong; Higgins, Nathan C.; Storace, Douglas A.; Liu, Andrew S. K.; Gifford, Adam M.; Burke, John F.; Campisi, Matthew; Kim, Yun-Soung; Avrin, Andrew E.; Spiegel, Jan Van der; Huang, Yonggang; Li, Ming; Wu, Jian; Rogers, John A.; Litt, Brian; Cohen, Yale E.

doi:10.1152/jn.00179.2013

A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings

Journal Article · Mon Sep 15 00:00:00 EDT 2014 · Journal of Neurophysiology

DOI:https://doi.org/10.1152/jn.00179.2013· OSTI ID:1874984

Escabí, Monty A. ^[1]; Read, Heather L. ^[2]; Viventi, Jonathan ^[3]; Kim, Dae-Hyeong ^[4]; Higgins, Nathan C. ^[2]; Storace, Douglas A. ^[2]; Liu, Andrew S. K. ^[5]; Gifford, Adam M. ^[5]; Burke, John F. ^[5]; Campisi, Matthew ^[6]; Kim, Yun-Soung ^[7]; Avrin, Andrew E. ^[5]; Spiegel, Jan Van der ^[5]; Huang, Yonggang ^[8]; Li, Ming ^[9]; Wu, Jian ^[10]; Rogers, John A. ^[7]; Litt, Brian ^[5]; Cohen, Yale E. ^[5]

Univ. of Connecticut, Storrs, CT (United States); University of Illinois
Univ. of Connecticut, Storrs, CT (United States)
New York Univ. (NYU), NY (United States); Polytechnic Inst. of New York Univ., Brooklyn, NY (United States)
Seoul National Univ. (Korea, Republic of)
Univ. of Pennsylvania, Philadelphia, PA (United States)
Polytechnic Inst. of New York Univ., Brooklyn, NY (United States)
Univ. of Illinois at Urbana-Champaign, IL (United States)
Northwestern Univ., Evanston, IL (United States)
Dalian Univ. of Technology (China)
Tsinghua Univ., Beijing (China)

Our understanding of the large-scale population dynamics of neural activity is limited, in part, by our inability to record simultaneously from large regions of the cortex. Here, we validated the use of a large-scale active microelectrode array that simultaneously records 196 multiplexed micro-electrocortigraphical (μECoG) signals from the cortical surface at a very high density (1,600 electrodes/cm²). We compared μECoG measurements in auditory cortex using a custom “active” electrode array to those recorded using a conventional “passive” μECoG array. Both of these array responses were also compared with data recorded via intrinsic optical imaging, which is a standard methodology for recording sound-evoked cortical activity. Custom active μECoG arrays generated more veridical representations of the tonotopic organization of the auditory cortex than current commercially available passive μECoG arrays. Furthermore, the cortical representation could be measured efficiently with the active arrays, requiring as little as 13.5 s of neural data acquisition. Next, we generated spectrotemporal receptive fields from the recorded neural activity on the active μECoG array and identified functional organizational principles comparable to those observed using intrinsic metabolic imaging and single-neuron recordings. Furthermore, this new electrode array technology has the potential for large-scale, temporally precise monitoring and mapping of the cortex, without the use of invasive penetrating electrodes.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation

Grant/Contract Number:: FG02-07ER46471; FG02-07ER46453

OSTI ID:: 1874984

Journal Information:: Journal of Neurophysiology, Journal Name: Journal of Neurophysiology Journal Issue: 6 Vol. 112; ISSN 0022-3077

Publisher:: American Physiological SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
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electrocorticography
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topography
μECoG

A high-density, high-channel count, multiplexed μECoG array for auditory-cortex recordings

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