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Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling

Journal Article · · Science
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  1. St.Jude Children's Research Hospital, Memphis, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  3. Vanderbilt Univ., Nashville, TN (United States)
  4. St. Jude Children's Hospital, Memphis, TN (United States)
+ Show Author Affiliations

Circuits in the auditory cortex are highly susceptible to acoustic influences during an early postnatal critical period. The auditory cortex selectively expands neural representations of enriched acoustic stimuli, a process important for human language acquisition. Adults lack this plasticity. We show in the murine auditory cortex that juvenile plasticity can be reestablished in adulthood if acoustic stimuli are paired with disruption of ecto-5'-nucleotidase–dependent adenosine production or A1–adenosine receptor signaling in the auditory thalamus. This plasticity occurs at the level of cortical maps and individual neurons in the auditory cortex of awake adult mice and is associated with long-term improvement of tone-discrimination abilities. We determined that, in adult mice, disrupting adenosine signaling in the thalamus rejuvenates plasticity in the auditory cortex and improves auditory perception.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1376640
Journal Information:
Science, Journal Name: Science Journal Issue: 6345 Vol. 356; ISSN 0036-8075
Publisher:
AAASCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (8)

Emerging Roles of Synapse Organizers in the Regulation of Critical Periods journal September 2019
Evidence of Hyperacusis in Adult Rats Following Non-traumatic Sound Exposure journal October 2019
Adenosine A 1 Receptor mRNA Expression by Neurons and Glia in the Auditory Forebrain: Adora1 receptors in auditory forebrain journal October 2018
Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity journal November 2019
Synaptic and circuit development of the primary sensory cortex journal April 2018
Inhibitory circuit gating of auditory critical-period plasticity journal January 2018
Earliest experience of rare but not frequent sounds cause long term changes in the adult auditory cortex posted_content October 2020
Cell type- and tissue-specific functions of ecto-5′-nucleotidase (CD73) journal December 2019

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