Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Cervical Precancers and Cancers Attributed to HPV Types by Race and Ethnicity: Implications for Vaccination, Screening, and Management

Journal Article · · JNCI, Journal of the National Cancer Institute
DOI:https://doi.org/10.1093/jnci/djac034· OSTI ID:1872251
; ; ; ; ; ; ; ; ; ; ; ; ; ;
Abstract Background

Racial and ethnic variations in attribution of cervical precancer and cancer to human papillomavirus (HPV) types may result in different HPV vaccine protection, screening test coverage, and clinical management.

Methods

Pooling data from 7 US studies, we calculated the proportional attribution of precancers and cancers to HPV types using HPV DNA typing from diagnosis. All statistical tests were 2-sided.

Results

For all racial and ethnic groups, most cases of cervical intraepithelial neoplasia grade 3 (CIN3) (84.2%-90.8% of 5526) and squamous cell carcinoma (SCC) (90.4%-93.8% of 1138) were attributed to types targeted by the 9-valent vaccine. A higher proportion of CIN3s were attributed to nonvaccine HPV types among non-Hispanic Black women (15.8%) compared with non-Hispanic Asian or Pacific Islander (9.7%; P = .002), non-Hispanic White (9.2%; P < .001), and Hispanic (11.3%; P = .004) women. The proportion of SCCs attributed to 9-valent types was similar by race and ethnicity (P = .80). A higher proportion of CIN3s were attributed to nonvaccine HPV35 among non-Hispanic Black (9.0%) compared with non-Hispanic Asian or Pacific Islander (2.2%), non-Hispanic White (2.5%), and Hispanic (3.0%; all P < .001) women. Compared with CIN3, the proportion of SCCs attributed to HPV35 among non-Hispanic Black women (3.2%) was lower and closer to other groups (0.3%-2.1%; P = .70).

Conclusion

The 9-valent HPV vaccine will prevent nearly all cervical precancers and invasive cancers among major racial and ethnic groups in the United States. Adding HPV35 to vaccines could prevent a small percentage of CIN3s and SCCs, with greater potential impact for CIN3s among Black women. HPV screening tests target high-risk HPV types, including HPV35. Future genotyping triage strategies could consider the importance of HPV35- and other HPV16-related types.

Sponsoring Organization:
USDOE
OSTI ID:
1872251
Journal Information:
JNCI, Journal of the National Cancer Institute, Journal Name: JNCI, Journal of the National Cancer Institute Journal Issue: 6 Vol. 114; ISSN 0027-8874
Publisher:
Oxford University PressCopyright Statement
Country of Publication:
United States
Language:
English

References (29)

Individual and geographic disparities in human papillomavirus types 16/18 in high-grade cervical lesions: Associations with race, ethnicity, and poverty journal May 2013
Racial differences in HPV type 16 prevalence in women with ASCUS of the uterine cervix journal April 2020
Multiple human papillomavirus genotype infections in cervical cancer progression in the study to understand cervical cancer early endpoints and determinants journal July 2009
Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication journal April 2010
Human papillomavirus types in 115,789 HPV-positive women: A meta-analysis from cervical infection to cancer journal March 2012
Human papillomavirus prevalence and type distribution in invasive cervical cancer in sub-Saharan Africa: Cervical cancer in sub-Saharan Africa journal November 2013
Worldwide burden of cancer attributable to HPV by site, country and HPV type: Worldwide burden of cancer attributable to HPV journal June 2017
Cervical adenocarcinoma in situ : Human papillomavirus types and incidence trends in five states, 2008–2015 journal April 2019
Identification of HPV genotypes causing cervical precancer using tissue‐based genotyping journal May 2020
Association of HPV35 with cervical carcinogenesis among women of African ancestry: Evidence of viral‐host interaction with implications for disease intervention journal May 2020
Comparisons of HPV DNA detection by MY09/11 PCR methods journal September 2002
HPV genotypes and cervical intraepithelial neoplasia in a multiethnic cohort in the southeastern USA journal June 2014
A review of human carcinogens—Part B: biological agents journal April 2009
Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study journal November 2010
A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs journal May 2020
A review of the FDA-approved molecular testing platforms for human papillomavirus journal September 2019
Prevalence of human papillomavirus (HPV)-vaccine types by race/ethnicity and sociodemographic factors in women with high-grade cervical intraepithelial neoplasia (CIN2/3/AIS), Alameda County, California, United States journal January 2020
Carcinogenic human papillomavirus infection journal December 2016
Human Papillomavirus Genotype Distributions: Implications for Vaccination and Cancer Screening in the United States journal April 2009
US Assessment of HPV Types in Cancers: Implications for Current and 9-Valent HPV Vaccines journal April 2015
2019 ASCCP Risk-Based Management Consensus Guidelines: Methods for Risk Estimation, Recommended Management, and Validation journal January 2020
Prevalence of Human Papillomavirus Types in Invasive Cervical Cancers From 7 US Cancer Registries Before Vaccine Introduction journal January 2014
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix journal January 2018
Comparison of the cobas Human Papillomavirus (HPV) Test with the Hybrid Capture 2 and Linear Array HPV DNA Tests journal January 2012
The causal relation between human papillomavirus and cervical cancer journal April 2002
HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States journal February 2015
The Role of Human Papillomavirus Genotyping in Cervical Cancer Screening: A Large-Scale Evaluation of the cobas HPV Test journal September 2015
HPV Genotypes in High Grade Cervical Lesions and Invasive Cervical Carcinoma as Detected by Two Commercial DNA Assays, North Carolina, 2001–2006 journal March 2012
Meta-Analysis on Prevalence and Attribution of Human Papillomavirus Types 52 and 58 in Cervical Neoplasia Worldwide journal September 2014

Similar Records

Prevalence of human papillomavirus genotypes in high-grade cervical precancer and invasive cervical cancer from cancer registries before and after vaccine introduction in the United States
Journal Article · Tue Jul 20 20:00:00 EDT 2021 · Cancer (Philadelphia) · OSTI ID:1981396
Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001–2017
Journal Article · Tue Oct 11 20:00:00 EDT 2022 · Preventive Medicine · OSTI ID:2425830

Related Subjects