Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Jian, Tengyue; Zhou, Yicheng; Wang, Peipei; Yang, Wenchao; Mu, Peng; Zhang, Xin; Zhang, Xiao; Chen, Chun-Long

doi:10.1038/s41467-022-30285-9

Title: Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

Journal Article · Tue May 31 00:00:00 EDT 2022 · Nature Communications

DOI:https://doi.org/10.1038/s41467-022-30285-9· OSTI ID:1870546

Jian, Tengyue; Zhou, Yicheng; Wang, Peipei;

; Mu, Peng;

; Zhang, Xiao;

Developing tunable and stable peroxidase mimetics with high catalytic efficiency provides a promising opportunity to improve and expand enzymatic catalysis in lignin depolymerization. A class of peptoid-based peroxidase mimetics with tunable catalytic activity and high stability is developed by constructing peptoids and hemins into self-assembled crystalline nanomaterials. By varying peptoid side chain chemistry to tailor the microenvironment of active sites, these self-assembled peptoid/hemin nanomaterials (Pep/hemin) exhibit highly modulable catalytic activities toward two lignin model substrates 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 3,3’,5,5’-tetramethylbenzidine. Among them, a Pep/hemin complex containing the pyridyl side chain showed the best catalytic efficiency (Vmax/Km = 5.81 × 10-3 s-1). These Pep/hemin catalysts are highly stable; kinetics studies suggest that they follow a peroxidase-like mechanism. Moreover, they exhibit a high efficacy on depolymerization of a biorefinery lignin. Because Pep/hemin catalysts are highly robust and tunable, we expect that they offer tremendous opportunities for lignin valorization to high value products.

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Research Organization:: Univ. of Washington, Seattle, WA (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); National Science Foundation (NSF); USDA NIFA

Grant/Contract Number:: SC0019288; 1454575; 2018-67009-27902; AC05‐76RL01830; AC05-76RL01830

OSTI ID:: 1870546

Alternate ID(s):: OSTI ID: 1873420; OSTI ID: 1886314

Report Number(s):: PNNL-SA-167428; 3025; PII: 30285

Journal Information:: Nature Communications, Journal Name: Nature Communications Vol. 13 Journal Issue: 1; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Title: Highly stable and tunable peptoid/hemin enzymatic mimetics with natural peroxidase-like activities

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