Peptoid-based hierarchically-structured biomimetic nanomaterials: Synthesis, characterization and applications

Liu, Jianli; Cai, Bin; Cui, Lifeng; Chen, Chun-Long

doi:10.1007/s40843-020-1296-8

Peptoid-based hierarchically-structured biomimetic nanomaterials: Synthesis, characterization and applications

Journal Article · Wed Apr 22 00:00:00 EDT 2020 · Science China Materials

DOI:https://doi.org/10.1007/s40843-020-1296-8· OSTI ID:1755199

Liu, Jianli ^[1]; Cai, Bin ^[2]; Cui, Lifeng ^[3]; ^[2]

Dongguan Univ. of Technology (China); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Dongguan Univ. of Technology (China)

Peptoids (or poly-N-substituted glycines) is a promising class of bioinspired sequence-defined polymers due to their highly efficient synthesis, high chemical stability, enzyme hydrolysis resistance, and biocompatibility. By tuning the side chain chemistry of peptoids, it allows for a precise control over sequences and achieving a large side-chain diversity. Due to these unique features, in the last several years, many amphiphilic peptoids were designed as highly tunable building blocks for the preparation of biomimetic nanomaterials with well-defined hierarchical structures and desired functionalities. In this paper, we provide an overview of the recent achievements in this area by dividing them into the following three aspects. First, mica- and silica-templated peptoid self-assembly was summarized. Here, the presence of inorganic substrates provides the guarantee of investigating their self-assembly mechanisms and interactions between peptoids and substrates using nanoscale characterization techniques, particularly in situ atomic force spectroscopy (AFM) and AFM-based dynamic force spectroscopy (AFM-DFS). Second, solution-phase self-assembly of peptoids into nanotubes and nanosheets was presented, as well as their self-repair properties. Third, the applications of peptoid based nanomaterials were outlined, including the construction of catalytic nanomaterials as a template and cytosolic delivery as cargoes.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Univ. of Washington, Seattle, WA (United States)

Sponsoring Organization:: Dongguan Univ. of Technology; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-76RL01830; SC0019288

OSTI ID:: 1755199

Alternate ID(s):: OSTI ID: 1781106

Report Number(s):: PNNL-SA--152798

Journal Information:: Science China Materials, Journal Name: Science China Materials Journal Issue: 7 Vol. 63; ISSN 2095-8226

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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