Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Tr

Journal Article · · J. Med. Chem.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1869980
Journal Information:
J. Med. Chem., Journal Name: J. Med. Chem. Journal Issue: (7) Vol. 65
Country of Publication:
United States
Language:
ENGLISH

References (25)

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors journal November 2014
Chemical modification of gene silencing oligonucleotides for drug discovery and development journal April 2005
A kinase-cGAS cascade to synthesize a therapeutic STING activator journal March 2022
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity journal May 2015
Thermodynamic Stability of Carbonic Anhydrase:  Measurements of Binding Affinity and Stoichiometry Using ThermoFluor journal April 2005
STING: infection, inflammation and cancer journal November 2015
Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods journal August 1993
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING journal December 2018
STING signaling and host defense against microbial infection journal December 2019
Novel Applications of Biocatalysis to Stereochemistry Determination of 2′3′-cGAMP Bisphosphorothioate (2′3′-cG S A S MP) journal June 2020
Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA journal January 2001
An orally available non-nucleotide STING agonist with antitumor activity journal August 2020
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs journal October 2014
One-Flask Syntheses of c-di-GMP and the [ R p , R p ] and [ R p , S p ] Thiophosphate Analogues journal July 2010
2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers journal July 2008
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase journal May 2013
Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field journal February 2015
Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective journal December 2019
Comprehensive analysis of the clinical immuno-oncology landscape journal January 2018
Immunotherapy with a sting journal August 2020
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING journal July 2013
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery journal September 2004
Combinations take centre stage in PD1/PDL1 inhibitor clinical trials journal November 2020
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies journal January 2019
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing journal September 2016

Similar Records

Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies
Journal Article · Thu Sep 05 00:00:00 EDT 2019 · Journal of Medicinal Chemistry · OSTI ID:1577169

Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia
Journal Article · Mon Jan 09 23:00:00 EST 2023 · Journal of Medicinal Chemistry · OSTI ID:2423389

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products
Journal Article · Thu Dec 31 23:00:00 EST 1987 · J. Virol.; (United States) · OSTI ID:5438195

Related Subjects