Healthy humans can be a source of antibodies countering COVID-19

Velappan, Nileena; Nguyen, Hau B.; Micheva-Viteva, Sofiya; Bedinger, Daniel; Ye, Chunyan; Mangadu, Betty; Watts, Austin J.; Meagher, Robert; Bradfute, Steven; Hu, Bin; Waldo, Geoffrey S.; Lillo, Antonietta M.

doi:10.1080/21655979.2022.2076390

Healthy humans can be a source of antibodies countering COVID-19

Journal Article · Sat May 21 00:00:00 EDT 2022 · Bioengineered

DOI:https://doi.org/10.1080/21655979.2022.2076390· OSTI ID:1869347

^[1]; Nguyen, Hau B. ^[1]; Micheva-Viteva, Sofiya ^[1]; Bedinger, Daniel ^[2]; Ye, Chunyan ^[3]; Mangadu, Betty ^[4]; Watts, Austin J.; ^[4]; Bradfute, Steven ^[3]; Hu, Bin ^[1]; Waldo, Geoffrey S. ^[1]; Lillo, Antonietta M. ^[1]

Biosciences Division, Los Alamos National Laboratory, Los Alamos, NM 87547, USA
Experimental division, Carterra Inc, Walnut Creek, CA, 94568, USA
Center for Global Health and Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA
Biotechnology and Bioengineering Department, Sandia National Laboratories, Livermore, CA, 94551, USA

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Sponsoring Organization:: USDOE

OSTI ID:: 1869347

Alternate ID(s):: OSTI ID: 1877112
OSTI ID: 1974926

Journal Information:: Bioengineered, Journal Name: Bioengineered Journal Issue: 5 Vol. 13; ISSN 2165-5979

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: United States

Language:: English

References (73)

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19: A Randomized Clinical Trial Gottlieb, Robert L.; Nirula, Ajay; Chen, Peter JAMA, Vol. 325, Issue 7 https://doi.org/10.1001/jama.2021.0202	journal	February 2021
Microfluidic Chips for Point-of-Care Immunodiagnostics Gervais, Luc; de Rooij, Nico; Delamarche, Emmanuel Advanced Materials, Vol. 23, Issue 24 https://doi.org/10.1002/adma.201100464	journal	May 2011
Neutralizing antibodies targeting the SARS‐CoV‐2 receptor binding domain isolated from a naïve human antibody library Bell, Benjamin N.; Powell, Abigail E.; Rodriguez, Carlos Protein Science, Vol. 30, Issue 4 https://doi.org/10.1002/pro.4044	journal	February 2021
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency Shusta, Eric V.; Kieke, Michele C.; Parke, Evan Journal of Molecular Biology, Vol. 292, Issue 5, p. 949-956 https://doi.org/10.1006/jmbi.1999.3130	journal	October 1999
Antibodies against non-immunizing antigens derived from a large immune scFv library Moon, Sung Ah; Ki, Min Kyung; Lee, Sungyoung Molecules and Cells, Vol. 31, Issue 6 https://doi.org/10.1007/s10059-011-2268-8	journal	April 2011
Phage-Displayed Antibody Libraries Lillo, A.; Mckenzie, K.; Janda, K. Cell Biology, Vol. 1, p. 491-496 https://doi.org/10.1016/B978-012164730-8/50060-5	book	January 2006
Loss of a neutralizing epitope by a spontaneous point mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker. di Marzo Veronese, F.; Reitz, M. S.; Gupta, G. Journal of Biological Chemistry, Vol. 268, Issue 34 https://doi.org/10.1016/S0021-9258(19)74471-8	journal	December 1993
[25] Yeast surface display for directed evolution of protein expression, affinity, and stability Boder, Eric T.; Wittrup, K. Dane Methods in Enzymology, Vol. 328, p. 430-444 https://doi.org/10.1016/S0076-6879(00)28410-3	book	January 2000
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Lu, Roujian; Zhao, Xiang; Li, Juan The Lancet, Vol. 395, Issue 10224 https://doi.org/10.1016/S0140-6736(20)30251-8	journal	February 2020
A distinct name is needed for the new coronavirus Jiang, Shibo; Shi, Zhengli; Shu, Yuelong The Lancet, Vol. 395, Issue 10228 https://doi.org/10.1016/S0140-6736(20)30419-0	journal	March 2020
Diversity in the CDR3 Region of VH Is Sufficient for Most Antibody Specificities Xu, John L.; Davis, Mark M. Immunity, Vol. 13, Issue 1 https://doi.org/10.1016/S1074-7613(00)00006-6	journal	July 2000
Viral load of SARS-CoV-2 in clinical samples Pan, Yang; Zhang, Daitao; Yang, Peng The Lancet Infectious Diseases, Vol. 20, Issue 4 https://doi.org/10.1016/S1473-3099(20)30113-4	journal	April 2020
Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity Chakraborty, Sandipan Biochemical and Biophysical Research Communications, Vol. 538 https://doi.org/10.1016/j.bbrc.2021.01.035	journal	January 2021
Integrated LAMP and immunoassay platform for diarrheal disease detection Phaneuf, Christopher R.; Mangadu, Betty; Tran, Huu M. Biosensors and Bioelectronics, Vol. 120 https://doi.org/10.1016/j.bios.2018.08.005	journal	November 2018
Point of care testing for infectious diseases Chen, Hui; Liu, Kengku; Li, Zhao Clinica Chimica Acta, Vol. 493 https://doi.org/10.1016/j.cca.2019.03.008	journal	June 2019
Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus Korber, Bette; Fischer, Will M.; Gnanakaran, Sandrasegaram Cell, Vol. 182, Issue 4 https://doi.org/10.1016/j.cell.2020.06.043	journal	August 2020
A Human Single-Chain Antibody Specific for Integrin α3β1 Capable of Cell Internalization and Delivery of Antitumor Agents Lillo, Antonietta M.; Sun, Chengzao; Gao, Changshou Chemistry & Biology, Vol. 11, Issue 7 https://doi.org/10.1016/j.chembiol.2004.04.018	journal	July 2004
A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2 Grifoni, Alba; Sidney, John; Zhang, Yun Cell Host & Microbe, Vol. 27, Issue 4 https://doi.org/10.1016/j.chom.2020.03.002	journal	April 2020
Identification of Human Single-Domain Antibodies against SARS-CoV-2 Wu, Yanling; Li, Cheng; Xia, Shuai Cell Host & Microbe, Vol. 27, Issue 6 https://doi.org/10.1016/j.chom.2020.04.023	journal	June 2020
Where are we with monoclonal antibodies for multidrug-resistant infections? McConnell, Michael J. Drug Discovery Today, Vol. 24, Issue 5 https://doi.org/10.1016/j.drudis.2019.03.002	journal	May 2019
Comparison of automated SARS-CoV-2 antigen test for COVID-19 infection with quantitative RT-PCR using 313 nasopharyngeal swabs, including from seven serially followed patients Hirotsu, Yosuke; Maejima, Makoto; Shibusawa, Masahiro International Journal of Infectious Diseases, Vol. 99 https://doi.org/10.1016/j.ijid.2020.08.029	journal	October 2020
Selection and characterization of scFv antibodies against the Sin Nombre hantavirus nucleocapsid protein Velappan, Nileena; Martinez, Jennifer S.; Valero, Rosa Journal of Immunological Methods, Vol. 321, Issue 1-2, p. 60-69 https://doi.org/10.1016/j.jim.2007.01.011	journal	April 2007
Fluorescence linked immunosorbant assays using microtiter plates Velappan, N.; Clements, J.; Kiss, C. Journal of Immunological Methods, Vol. 336, Issue 2 https://doi.org/10.1016/j.jim.2008.04.007	journal	July 2008
Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays Mehalko, Jennifer; Drew, Matthew; Snead, Kelly Protein Expression and Purification, Vol. 179 https://doi.org/10.1016/j.pep.2020.105802	journal	March 2021
IUPAC-Consistent Approach to the Limit of Detection in Partial Least-Squares Calibration Allegrini, Franco; Olivieri, Alejandro C. Analytical Chemistry, Vol. 86, Issue 15 https://doi.org/10.1021/ac501786u	journal	July 2014
Centrifugal Microfluidic Platform for Ultrasensitive Detection of Botulinum Toxin Koh, Chung-Yan; Schaff, Ulrich Y.; Piccini, Matthew E. Analytical Chemistry, Vol. 87, Issue 2, p. 922-928 https://doi.org/10.1021/ac504054u	journal	December 2014
Comparing the Binding Interactions in the Receptor Binding Domains of SARS-CoV-2 and SARS-CoV Amin, Muhamed; Sorour, Mariam K.; Kasry, Amal The Journal of Physical Chemistry Letters, Vol. 11, Issue 12 https://doi.org/10.1021/acs.jpclett.0c01064	journal	June 2020
Targeting Heat Shock Proteins on Cancer Cells: Selection, Characterization, and Cell-Penetrating Properties of a Peptidic GRP78 Ligand ^† Kim, Youngsoo; Lillo, Antonietta M.; Steiniger, Sebastian C. J. Biochemistry, Vol. 45, Issue 31 https://doi.org/10.1021/bi060264j	journal	August 2006
Phage Display Smith, George P.; Petrenko, Valery A. Chemical Reviews, Vol. 97, Issue 2 https://doi.org/10.1021/cr960065d	journal	April 1997
Reproducibility: Standardize antibodies used in research Bradbury, Andrew; Plückthun, Andreas Nature, Vol. 518, Issue 7537 https://doi.org/10.1038/518027a	journal	February 2015
Exploiting recombination in single bacteria to make large phage antibody libraries Sblattero, Daniele; Bradbury, Andrew Nature Biotechnology, Vol. 18, Issue 1 https://doi.org/10.1038/71958	journal	January 2000
Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein Xia, Shuai; Zhu, Yun; Liu, Meiqin Cellular & Molecular Immunology, Vol. 17, Issue 7 https://doi.org/10.1038/s41423-020-0374-2	journal	February 2020
U1 snRNP regulates cancer cell migration and invasion in vitro Oh, Jung-Min; Venters, Christopher C.; Di, Chao Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-019-13993-7	journal	January 2020
Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor Yang, Jinsung; Petitjean, Simon J. L.; Koehler, Melanie Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-18319-6	journal	September 2020
SARS-CoV-2 neutralizing human recombinant antibodies selected from pre-pandemic healthy donors binding at RBD-ACE2 interface Bertoglio, Federico; Meier, Doris; Langreder, Nora Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-21609-2	journal	March 2021
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain Tan, Timothy J. C.; Yuan, Meng; Kuzelka, Kaylee Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-24123-7	journal	June 2021
A new coronavirus associated with human respiratory disease in China Wu, Fan; Zhao, Su; Yu, Bin Nature, Vol. 579, Issue 7798 https://doi.org/10.1038/s41586-020-2008-3	journal	February 2020
A pneumonia outbreak associated with a new coronavirus of probable bat origin Zhou, Peng; Yang, Xing-Lou; Wang, Xian-Guang Nature, Vol. 579, Issue 7798 https://doi.org/10.1038/s41586-020-2012-7	journal	February 2020
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor Lan, Jun; Ge, Jiwan; Yu, Jinfang Nature, Vol. 581, Issue 7807 https://doi.org/10.1038/s41586-020-2180-5	journal	March 2020
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2 Shi, Rui; Shan, Chao; Duan, Xiaomin Nature, Vol. 584, Issue 7819 https://doi.org/10.1038/s41586-020-2381-y	journal	May 2020
Rapid production of SARS-CoV-2 receptor binding domain (RBD) and spike specific monoclonal antibody CR3022 in Nicotiana benthamiana Rattanapisit, Kaewta; Shanmugaraj, Balamurugan; Manopwisedjaroen, Suwimon Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-74904-1	journal	October 2020
A single donor is sufficient to produce a highly functional in vitro antibody library Erasmus, M. Frank; D’Angelo, Sara; Ferrara, Fortunato Communications Biology, Vol. 4, Issue 1 https://doi.org/10.1038/s42003-021-01881-0	journal	March 2021
Toward one-step point-of-care immunodiagnostics using capillary-driven microfluidics and PDMS substrates Gervais, Luc; Delamarche, Emmanuel Lab on a Chip, Vol. 9, Issue 23 https://doi.org/10.1039/b906523g	journal	January 2009
A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate Walsh III, David I.; Sommer, Gregory J.; Schaff, Ulrich Y. Lab on a Chip, Vol. 14, Issue 15 https://doi.org/10.1039/c4lc00279b	journal	January 2014
Centrifugal sedimentation immunoassays for multiplexed detection of enteric bacteria in ground water Litvinov, Julia; Moen, Scott T.; Koh, Chung-Yan Biomicrofluidics, Vol. 10, Issue 1 https://doi.org/10.1063/1.4939099	journal	January 2016
Using Phage Display to Select Antibodies Recognizing Post-translational Modifications Independently of Sequence Context Kehoe, John W.; Velappan, Nileena; Walbolt, Monica Molecular & Cellular Proteomics, Vol. 5, Issue 12 https://doi.org/10.1074/mcp.M600314-MCP200	journal	September 2006
Epigenetic regulation of T cell development Dutta, Avik; Venkataganesh, Harini; Love, Paul E. International Reviews of Immunology https://doi.org/10.1080/08830185.2021.2022661	journal	December 2021
Selection and characterization of FcεRI phospho-ITAM specific antibodies Velappan, Nileena; Mahajan, Avanika; Naranjo, Leslie mAbs, Vol. 11, Issue 7 https://doi.org/10.1080/19420862.2019.1632113	journal	July 2019
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening Bailly, Marc; Mieczkowski, Carl; Juan, Veronica mAbs, Vol. 12, Issue 1 https://doi.org/10.1080/19420862.2020.1743053	journal	January 2020
The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America Spellberg, B.; Guidos, R.; Gilbert, D. Clinical Infectious Diseases, Vol. 46, Issue 2 https://doi.org/10.1086/524891	journal	January 2008
Development of Resistance to Passive Therapy with a Potently Neutralizing Humanized Monoclonal Antibody against West Nile Virus Zhang, Shuliu; Vogt, Matthew R.; Oliphant, Theodore The Journal of Infectious Diseases, Vol. 200, Issue 2 https://doi.org/10.1086/599794	journal	July 2009
Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy Zeng, Xin; Li, Lingfang; Lin, Jing Antibody Therapeutics, Vol. 3, Issue 2 https://doi.org/10.1093/abt/tbaa008	journal	April 2020
Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibody Titers in Convalescent Plasma and Recipients in New Mexico: An Open Treatment Study in Patients With Coronavirus Disease 2019 Bradfute, Steven B.; Hurwitz, Ivy; Yingling, Alexandra V. The Journal of Infectious Diseases, Vol. 222, Issue 10 https://doi.org/10.1093/infdis/jiaa505	journal	August 2020
IgBLAST: an immunoglobulin variable domain sequence analysis tool Ye, Jian; Ma, Ning; Madden, Thomas L. Nucleic Acids Research, Vol. 41, Issue W1 https://doi.org/10.1093/nar/gkt382	journal	May 2013
Antibodies: an alternative for antibiotics? Berghman, L. R.; Abi-Ghanem, D.; Waghela, S. D. Poultry Science, Vol. 84, Issue 4 https://doi.org/10.1093/ps/84.4.660	journal	April 2005
A minimal peptide substrate in biotin holoenzyme synthetase-catalyzed biotinylation Beckett, Dorothy; Kovaleva, Elena; Schatz, Peter J. Protein Science, Vol. 8, Issue 4 https://doi.org/10.1110/ps.8.4.921	journal	January 1999
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation Wrapp, Daniel; Wang, Nianshuang; Corbett, Kizzmekia S. Science, Vol. 367, Issue 6483 https://doi.org/10.1126/science.abb2507	journal	February 2020
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV Yuan, Meng; Wu, Nicholas C.; Zhu, Xueyong Science, Vol. 368, Issue 6491 https://doi.org/10.1126/science.abb7269	journal	April 2020
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail Hansen, Johanna; Baum, Alina; Pascal, Kristen E. Science https://doi.org/10.1126/science.abd0827	journal	June 2020
Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies Baum, Alina; Fulton, Benjamin O.; Wloga, Elzbieta Science https://doi.org/10.1126/science.abd0831	journal	June 2020
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study Hastie, Kathryn M.; Li, Haoyang; Bedinger, Daniel Science, Vol. 374, Issue 6566 https://doi.org/10.1126/science.abh2315	journal	October 2021
A Novel High-Throughput Screen Reveals Yeast Genes That Increase Secretion of Heterologous Proteins Wentz, A. E.; Shusta, E. V. Applied and Environmental Microbiology, Vol. 73, Issue 4 https://doi.org/10.1128/AEM.02427-06	journal	December 2006
Point-of-Care Testing for Infectious Diseases: Past, Present, and Future Kozel, Thomas R.; Burnham-Marusich, Amanda R. Journal of Clinical Microbiology, Vol. 55, Issue 8 https://doi.org/10.1128/JCM.00476-17	journal	August 2017
Using phage display selected antibodies to dissect microbiomes for complete de novo genome sequencing of low abundance microbes Close, Devin W.; Ferrara, Fortunato; Dichosa, Armand EK BMC Microbiology, Vol. 13, Issue 1 https://doi.org/10.1186/1471-2180-13-270	journal	January 2013
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants ter Meulen, Jan; van den Brink, Edward N.; Poon, Leo L. M. PLoS Medicine, Vol. 3, Issue 7 https://doi.org/10.1371/journal.pmed.0030237	journal	July 2006
Development of Phage-Based Single Chain Fv Antibody Reagents for Detection of Yersinia pestis Lillo, Antonietta M.; Ayriss, Joanne E.; Shou, Yulin PLoS ONE, Vol. 6, Issue 12 https://doi.org/10.1371/journal.pone.0027756	journal	December 2011
Beyond Helper Phage: Using "Helper Cells" to Select Peptide Affinity Ligands Phipps, M. Lisa; Lillo, Antoinetta M.; Shou, Yulin PLOS ONE, Vol. 11, Issue 9 https://doi.org/10.1371/journal.pone.0160940	journal	September 2016
Antibody display technologies: selecting the cream of the crop Valldorf, Bernhard; Hinz, Steffen C.; Russo, Giulio Biological Chemistry, Vol. 403, Issue 5-6 https://doi.org/10.1515/hsz-2020-0377	journal	March 2021
Immunodiagnostics and immunosensor design (IUPAC Technical Report) Gubala, Vladimir; Klein, Reinhild; Templeton, Douglas M. Pure and Applied Chemistry, Vol. 86, Issue 10 https://doi.org/10.1515/pac-2013-1027	journal	October 2014
Development of Anti-Yersinia pestis Human Antibodies with Features Required for Diagnostic and Therapeutic Applications Lillo, Antonietta M.; Velappan, Nileena; Kelliher, Julia M. ImmunoTargets and Therapy, Vol. Volume 9 https://doi.org/10.2147/ITT.S267077	journal	January 2020
Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions Sachdeva, Shivangi; Davis, Ronald W.; Saha, Amit K. Frontiers in Bioengineering and Biotechnology, Vol. 8 https://doi.org/10.3389/fbioe.2020.602659	journal	January 2021
Rapid, Portable, Multiplexed Detection of Bacterial Pathogens Directly from Clinical Sample Matrices Phaneuf, Christopher; Mangadu, Betty; Piccini, Matthew Biosensors, Vol. 6, Issue 4 https://doi.org/10.3390/bios6040049	journal	September 2016
Monoclonal antibodies in immunodiagnostic assays: a review of recent applications Mahmuda, A.; Bande, F.; Abdulhaleem, N. Sokoto Journal of Veterinary Sciences, Vol. 15, Issue 1 https://doi.org/10.4314/sokjvs.v15i1.1	journal	March 2017

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