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Divergence in the ABA gene regulatory network underlies differential growth control

Journal Article · · Nature Plants (Online)
 [1];  [2];  [3];  [3];  [3];  [4];  [2];  [2];  [2];  [3]
  1. Stanford Univ., CA (United States); Stanford University
  2. Louisiana State Univ., Baton Rouge, LA (United States)
  3. Stanford Univ., CA (United States)
  4. Salk Institute for Biological Studies, La Jolla, CA (United States)
+ Show Author Affiliations
The phytohormone abscisic acid (ABA) is a central regulator of acclimation to environmental stress; however, its contribution to differences in stress tolerance between species is unclear. To establish a comparative framework for understanding how stress hormone signalling pathways diverge across species, we studied the growth response of four Brassicaceae species to ABA treatment and generated transcriptomic and DNA affinity purification and sequencing datasets to construct a cross-species gene regulatory network (GRN) for ABA. In this work, comparison of genes bound directly by ABA-responsive element binding factors suggests that cis-factors are most important for determining the target loci represented in the ABA GRN of a particular species. Using this GRN, we reveal how rewiring of growth hormone subnetworks contributes to stark differences in the response to ABA in the extremophyte Schrenkiella parvula. Our study provides a model for understanding how divergence in gene regulation can lead to species-specific physiological outcomes in response to hormonal cues.
Research Organization:
Louisiana State University, Baton Rouge, LA (United States); Stanford Univ., CA (United States)
Sponsoring Organization:
Carnegie Institution for Science; National Science Foundation (NSF); Rural Development Administration (RDA); USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0020358
OSTI ID:
1866275
Alternate ID(s):
OSTI ID: 2282554
Journal Information:
Nature Plants (Online), Journal Name: Nature Plants (Online) Journal Issue: 5 Vol. 8; ISSN 2055-0278
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English

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59 BASIC BIOLOGICAL SCIENCES
ABA
abiotic stress
extremophyte
genomics
roots