Targeting Gut Bacteria Using Inulin‐Conjugated Mesoporous Silica Nanoparticles

von Baeckmann, Cornelia; Riva, Alessandra; Guggenberger, Patrick; Kählig, Hanspeter; Han, Seung Won; Inan, Deniz; Del Favero, Giorgia; Berry, David; Kleitz, Freddy

doi:10.1002/admi.202102558

Targeting Gut Bacteria Using Inulin‐Conjugated Mesoporous Silica Nanoparticles

Journal Article · Sun Apr 17 00:00:00 EDT 2022 · Advanced Materials Interfaces

DOI:https://doi.org/10.1002/admi.202102558· OSTI ID:1863447

^[1]; Riva, Alessandra ^[2]; Guggenberger, Patrick ^[1]; Kählig, Hanspeter ^[3]; Han, Seung Won ^[4]; Inan, Deniz ^[2]; ^[5]; ^[2]; ^[1]

Department of Inorganic Chemistry – Functional Materials Faculty of Chemistry University of Vienna Währinger Straße 42 Vienna 1090 Austria
Centre for Microbiology and Environmental Systems Science Department of Microbiology and Ecosystem Science Division of Microbial Ecology University of Vienna Djerassiplatz 1 Vienna 1030 Austria
Department of Organic Chemistry Faculty of Chemistry University of Vienna Währinger Straße 38 Vienna 1090 Austria
Institute for Basic Science (IBS) Center for Nanomaterials and Chemical Reactions Daejeon 34141 Republic of Korea
Department of Food Chemistry and Toxicology Faculty of Chemistry University of Vienna Währinger Straße 38 Vienna 1090 Austria

Abstract

To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin‐conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0019012

OSTI ID:: 1863447

Alternate ID(s):: OSTI ID: 1863449
OSTI ID: 1976222

Journal Information:: Advanced Materials Interfaces, Journal Name: Advanced Materials Interfaces Journal Issue: 14 Vol. 9; ISSN 2196-7350

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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