Analysis of recombinational hot spots associated with the p haplotype fo the mouse MHC
- Rutgers Univ., Piscataway, NJ (United States)
Most of the recombination events detected within the major histocompatibility complex (MHC) of the mouse fall into areas of limited physical size that have been designated recombinational hot spots. One of these hot spots, associated with the Ea gene, appears to be active only in the presence of the p haplotype of the MHC. To study the regulation of the Ea recombinational hot spot and its haplotype specificity, a high-resolution comparative map fo the MHC and adjacent regions was completed in four different backcrosses carrying the p haplotype. This mapping study utilized a total of 29 PCR-based molecular markers, including 7 newly developed markers spanning the region between Pim1 and D17Mit11 on Chromosome 17. The analysis of a total of 1093 backcross animals: (1) revealed that the presence of the p haplotype of the MHC is not sufficient to induce recombination at the Ea hot spot in a dominant manner, and (2) resulted in the definition of a new intra-MHC recombinational hot spot between the Tnfb and the H2-D genes.
- OSTI ID:
- 186088
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 23; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
An approach to mapping haplotype-specific recombination sites in human MHC class III
Physical mapping of the retinoid X receptor B gene in mouse and human
Genetic map of the fused locus on mouse Chromosome 17
Journal Article
·
Mon Dec 30 23:00:00 EST 1996
· Immunogenetics
·
OSTI ID:501869
Physical mapping of the retinoid X receptor B gene in mouse and human
Journal Article
·
Tue Jan 10 23:00:00 EST 1995
· Immunogenetics
·
OSTI ID:75604
Genetic map of the fused locus on mouse Chromosome 17
Journal Article
·
Thu Sep 01 00:00:00 EDT 1994
· Genomics
·
OSTI ID:186089