A 2-Mb YAC contig linking the plasminogen-apoprotein(a) gene family to the insulin-like growth factor 2 receptor (IGF2R) gene on the telomeric region of chromosome 6 (6q26-q27)
- San Raffaele Scientific Institute, Milan (Italy); and others
Chromosome 6 has been reported to be frequently rearranged in several human malignancies. In particular, deletions of the long arm of this chromosome are observed in melanomas, renal cell carcinomas, salivary gland adenocarcinomas, and ovarian carcinomas, as well as in lymphoid tumors such as acute lymphoblastic leukemia and B-cell non-Hodgkin lymphomas. Molecular studies of B-cell non-Hodgkin lymphomas using the loss of heterozygosity analysis allowed the definition of two distinct regions of minimal deletion (RMD), which were mapped to 6q25 to 6q27 and to 6q21 to 6q23, respectively. 24 refs., 2 figs.
- OSTI ID:
- 186045
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 22; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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