Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Valdez, Carlos A.; Be, Nicholas A.; Malfatti, Michael A.; Enright, Heather Ann; Bennion, Brian J.; Carpenter, Timothy S.; Hok, Saphon; Lao, Hio Leong; Nguyen, Tuan H.

Compounds for central reactivation of organophosphorus-based compound-inhibited acetylcholinesterase and/or inactivation of organophosphorus-based acetylcholinesterase inhibitors and related compositions methods and systems for making and using them

Patent · Mon Nov 29 23:00:00 EST 2021

OSTI ID:1860113

Valdez, Carlos A.; Be, Nicholas A.; Malfatti, Michael A.; Enright, Heather Ann; Bennion, Brian J.; Carpenter, Timothy S.; Hok, Saphon; Lao, Hio Leong; Nguyen, Tuan H.

Described herein are oxime compounds capable of inactivating OP-based AChE inhibitors, crossing the blood brain barrier (BBB), and/or reactivation of OP-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more OP-based AChE inhibitors, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of OP-based AChE inhibitors for decontamination.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 11,186,548

Application Number:: 16/198,627

OSTI ID:: 1860113

Country of Publication:: United States

Language:: English

References (20)

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