Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Valdez, Carlos A.; Be, Nicholas A.; Bennion, Brian; Carpenter, Tim; Enright, Heather Ann; Lightstone, Felice; Malfatti, Mike; McNerney, Margaret Windy; Nguyen, Tuan H.

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Patent · Tue Mar 17 00:00:00 EDT 2020

OSTI ID:1637828

Valdez, Carlos A.; Be, Nicholas A.; Bennion, Brian; Carpenter, Tim; Enright, Heather Ann; Lightstone, Felice; Malfatti, Mike; McNerney, Margaret Windy; Nguyen, Tuan H.

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 10,590,498

Application Number:: 15/595,400

OSTI ID:: 1637828

Country of Publication:: United States

Language:: English

References (20)

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