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Function-based probes for environmental microbiome analysis and methods of making and using the same

Patent ·
OSTI ID:1860048
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Probe embodiments for identifying analytes involved in biofuel or bioenergy production, bioremediation, or nutrient cycling as well as methods of making and use are described herein. In some embodiments, probes identifying cellulose degradation and/or sugar transport, lignin or chitin degradation, or peptide or toxin metabolism are included. In some embodiments, probes for identifying analytes in a soil sample are included in the compositions and methods disclosed herein.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
11,169,152
Application Number:
16/132,266
OSTI ID:
1860048
Country of Publication:
United States
Language:
English

References (8)

Activity-based protein profiling of microbes journal February 2015
Suite of Activity-Based Probes for Cellulose-Degrading Enzymes journal December 2012
A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes journal July 2009
Screening‐based discovery of Aspergillus fumigatus plant‐type chitinase inhibitors journal July 2014
Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms journal January 2010
β-Lactams and β-lactones as activity-based probes in chemical biology journal January 2012
Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes journal October 2016
Live-Cell Stimulated Raman Scattering Imaging of Alkyne-Tagged Biomolecules journal April 2014

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