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Bile salt hydrolase probe and method of making and using the same

Patent ·
OSTI ID:1859991
; ;
Probe embodiments for targeting, identifying, and isolating enzymes exhibiting BSH activity as well as devices and kits that use the probes are described herein. Methods of making and using the probes, devices, and kits are also described. In some embodiments, probes, devices, and kits for targeting, identifying, and isolating enzymes in a biological sample are disclosed. In some embodiments, compositions and methods of treatment using the probes, devices, and kits disclosed herein are described.
Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
11,155,573
Application Number:
16/159,429
OSTI ID:
1859991
Country of Publication:
United States
Language:
English

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Activity-Based Probes for Isoenzyme- and Site-Specific Functional Characterization of Glutathione S -Transferases journal November 2017
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Design, synthesis, and physico-chemical interactions of bile acid derived dimeric phospholipid amphiphiles with model membranes journal June 2015
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