Lessons learned from studying Histoplasma capsulatum extracellular vesicles

Book · Fri Dec 31 00:00:00 EST 2021

DOI:https://doi.org/10.1007/978-3-030-83391-6_2· OSTI ID:1846379

Zamith-Miranda, Daniel ^[1]; Alves, Lysangela R. ^[2]; Nakayasu, Ernesto S.  ^[3]; Nosanchuk, Joshua D. ^[4]

---

1. Albert Einstein College of Medicine
2. Carlos Chagas Institute, Fundac¸a~o Oswaldo Cruz (Fiocruz), Curitiba, Brazil
3. BATTELLE (PACIFIC NW LAB)
4. Albert Einstien Universtiy, Bronx, New York

Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 1846379
• Report Number(s): PNNL-SA-169908
• Resource Relation: Journal Volume: 432
• Country of Publication: Switzerland
• Language: English