Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Thanos, P K.

doi:10.1016/j.bbr.2009.10.020

Title: Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Journal Article · Thu Oct 22 00:00:00 EDT 2009 · Behavioural Brain Research

DOI:https://doi.org/10.1016/j.bbr.2009.10.020· OSTI ID:1838872

Thanos, P K.

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R+/+), both heterozygous (D4R+/−) and knockout (D4R−/−) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

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Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institute on Alcohol Abuse and Alcoholism (NIAAA)

DOE Contract Number:: SC0012704

OSTI ID:: 1838872

Report Number(s):: BNL-91369-2010-JA; BNL-91369-2010-JARP

Journal Information:: Behavioural Brain Research, Journal Name: Behavioural Brain Research

Country of Publication:: United States

Language:: English

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