Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine
Journal Article
·
· Behavioural Brain Research
OSTI ID:1014288
In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R{sup +/+}), both heterozygous (D4R{sup +/-}) and knockout (D4R{sup -/-}) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.
- Research Organization:
- BROOKHAVEN NATIONAL LABORATORY (BNL)
- Sponsoring Organization:
- DOE - OFFICE OF SCIENCE
- DOE Contract Number:
- AC02-98CH10886
- OSTI ID:
- 1014288
- Report Number(s):
- BNL--91369-2010-JA; KP1602010
- Journal Information:
- Behavioural Brain Research, Journal Name: Behavioural Brain Research Journal Issue: 2 Vol. 207
- Country of Publication:
- United States
- Language:
- English
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