Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Journal Article · Thu Oct 22 00:00:00 EDT 2009 · Behavioural Brain Research

OSTI ID:1014288

Thanos, P K

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R{sup +/+}), both heterozygous (D4R{sup +/-}) and knockout (D4R{sup -/-}) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: DOE - OFFICE OF SCIENCE
• DOE Contract Number: DE-AC02-98CH10886
• OSTI ID: 1014288
• Report Number(s): BNL-91369-2010-JA; R&D Project: MO085; KP1602010; TRN: US201111%%241
• Journal Information: Behavioural Brain Research, Vol. 207, Issue 2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
60 APPLIED LIFE SCIENCES
COCAINE
DOPAMINE
FOOD
GENETICS
MICE
PELLETS
reward
addiction
reinforcement
cognition
dopamine
receptors
mice
food
cocaine