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Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance C

Journal Article · · ACS Med. Chem. Lett.
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1836744
Journal Information:
ACS Med. Chem. Lett., Journal Name: ACS Med. Chem. Lett. Journal Issue: (4) Vol. 11
Country of Publication:
United States
Language:
ENGLISH

References (28)

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Discovery of ( R )-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury journal March 2013
Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses journal August 2004
Targeting Metalloenzymes for Therapeutic Intervention journal September 2018
Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction journal September 2013
Arginase: an emerging key player in the mammalian immune system: Arginase in the immune system journal September 2009
Design of Ester Prodrugs to Enhance Oral Absorption of Poorly Permeable Compounds: Challenges to the Discovery Scientist journal December 2003
L-arginine metabolism in myeloid cells controls T-lymphocyte functions journal June 2003
Palladium-Catalyzed Allylic Alkylation of Simple Ketones with Allylic Alcohols and Its Mechanistic Study journal May 2014
l-Arginine Consumption by Macrophages Modulates the Expression of CD3ζ Chain in T Lymphocytes journal July 2003
A Spectrophotometric Assay of Arginase journal August 2001
Arginase in patients with breast cancer journal February 2003
Targeting Intestinal Transporters for Optimizing Oral Drug Absorption journal November 2010
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity journal February 2019
Discovery of N -Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II journal August 2019
Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment journal December 2017
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design journal February 2018
Dual Palladium- and Proline-Catalyzed Allylic Alkylation of Enolizable Ketones and Aldehydes with Allylic Alcohols journal February 2009
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities journal August 2007
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells journal October 2008
Comprehensive analysis of the clinical immuno-oncology landscape journal January 2018
Serum Arginase Level in Patients with Gastric Cancer journal January 1994
Arginase Inhibitors: A Rational Approach Over One Century: AN EXHAUSTIVE REVIEW OF ARGINASE INHIBITORS journal November 2016
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response journal September 2005
Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design journal August 2011
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy journal August 2018

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