Antibody Targeted Metal–Organic Frameworks for Bioimaging Applications

Butler, Kimberly S.; Pearce, Charles J.; Nail, Elizabeth A.; Vincent, Grace A.; Sava Gallis, Dorina F.

doi:10.1021/acsami.0c07835

Antibody Targeted Metal–Organic Frameworks for Bioimaging Applications

Journal Article · Fri Jun 19 00:00:00 EDT 2020 · ACS Applied Materials and Interfaces

DOI:https://doi.org/10.1021/acsami.0c07835· OSTI ID:1834084

^[1]; Pearce, Charles J. ^[1]; Nail, Elizabeth A. ^[1]; Vincent, Grace A. ^[1]; ^[1]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Here, we report on the availability and chemical utility of primary amines within metal–organic frameworks (MOFs) for cell targeting. Primary amine groups represent one of the most versatile chemical moieties for conjugation to biologically relevant molecules, including antibodies and enzymes. Specifically, we used two different chemical conjugations schemes, utilizing the amino functionality on the organic linker: first, carbodiimide chemistry was used to link the primary amine to available carboxyl groups on the protein neutravidin; second, sulfhydryl cross-linking chemistry was used via Traut’s reagent scheme. Importantly, this is the first report that documents this methodology implemented with MOF systems. Finally, the ability of the EpCAM antibody targeted MOFs to bind to a human epithelial cell line (A549), a common target for imaging studies, was confirmed with confocal microscopy.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: NA0003525

OSTI ID:: 1834084

Report Number(s):: SAND--2020-8431J; 689941

Journal Information:: ACS Applied Materials and Interfaces, Journal Name: ACS Applied Materials and Interfaces Journal Issue: 28 Vol. 12; ISSN 1944-8244

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
antibody targeting
bioimaging
confocal microscopy
cytotoxicity
metal−organic frameworks
photoluminescence

Antibody Targeted Metal–Organic Frameworks for Bioimaging Applications

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