Radiolabeled antibody fragments

Patent · Tue Jun 06 04:00:00 EDT 1989

OSTI ID:5468404

Nicolotti, R A

This patent describes an antibody conjugate of the formula: wherein Ab is the residue of a Fab fragment of a monoclonal antibody. The antibody being one which retains antigen-binding activity following enzymatic removal for the F/sub c/ fragment and reductive cleavage of the disulfide bond joining the heavy chains; -S- is the residue of the free sulfhydryl group of the Fab' fragment; R is a divalent organic linker; and R' is a nontoxic, weakly acidic chelating group capable of forming a chelate with a radionuclide metal ion that is thermodynamically stable under physiological conditions and has a higher stability constant than a chelate of the radionuclide with transferrin in vivo.

• Assignee: Mallinckrodt, Inc., St. Louis, MO
• Patent Number(s): US 4837003
• Application Number: PPN: US 6650127A
• OSTI ID: 5468404
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIBODIES
BINDING ENERGY
CHALCOGENIDES
CHELATES
CHEMICAL COMPOSITION
COMPLEXES
DRUGS
ENERGY
IMMUNOLOGY
IMMUNOTHERAPY
IN VIVO
ISOTOPES
LABELLED COMPOUNDS
LABELLING
MEDICINE
MONOCLONAL ANTIBODIES
NUCLEAR MEDICINE
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
RADIOTHERAPY
SULFIDES
SULFUR COMPOUNDS
THERAPY