Radiolabeled antibody fragments

Patent · Tue Jun 06 00:00:00 EDT 1989

OSTI ID:5468404

Nicolotti, R A

This patent describes an antibody conjugate of the formula: wherein Ab is the residue of a Fab fragment of a monoclonal antibody. The antibody being one which retains antigen-binding activity following enzymatic removal for the F/sub c/ fragment and reductive cleavage of the disulfide bond joining the heavy chains; -S- is the residue of the free sulfhydryl group of the Fab' fragment; R is a divalent organic linker; and R' is a nontoxic, weakly acidic chelating group capable of forming a chelate with a radionuclide metal ion that is thermodynamically stable under physiological conditions and has a higher stability constant than a chelate of the radionuclide with transferrin in vivo.

• Assignee: Mallinckrodt, Inc., St. Louis, MO
• Patent Number(s): US 4837003
• Application Number: PPN: US 6650127A; TRN: 89-031320
• OSTI ID: 5468404
• Resource Relation: Patent File Date: 13 Sep 1984
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MONOCLONAL ANTIBODIES
LABELLING
BINDING ENERGY
CHELATES
CHEMICAL COMPOSITION
IN VIVO
LABELLED COMPOUNDS
NUCLEAR MEDICINE
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOPHARMACEUTICALS
SULFIDES
ANTIBODIES
CHALCOGENIDES
COMPLEXES
DRUGS
ENERGY
IMMUNOLOGY
IMMUNOTHERAPY
ISOTOPES
MEDICINE
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
SULFUR COMPOUNDS
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)