Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phe

Jiang, Bin; Duan, James J.-W.; Stachura, Sylwia; Karmakar, Ananta; Hemagiri, Hemalatha; Raut, Dhanya Kumar; Gupta, Arun Kumar; Weigelt, Carolyn A.; Khan, Javed; Sack, John S.; Wu, Dauh-Rurng; Yarde, Melissa; Shen, Ding-Ren; Galella, Michael A.; Mathur, Arvind; Zhao, Qihong; Salter-Cid, Luisa M.; Carter, Percy H.; Dhar, T.G. Murali

doi:10.1016/j.bmcl.2020.127392

Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phe

Journal Article · Tue Sep 01 00:00:00 EDT 2020 · Bioorg. Med. Chem. Lett.

DOI:https://doi.org/10.1016/j.bmcl.2020.127392· OSTI ID:1833652

Jiang, Bin; Duan, James J.-W.; Stachura, Sylwia; Karmakar, Ananta; Hemagiri, Hemalatha; Raut, Dhanya Kumar; Gupta, Arun Kumar; Weigelt, Carolyn A.; Khan, Javed; Sack, John S.; Wu, Dauh-Rurng; Yarde, Melissa; Shen, Ding-Ren; Galella, Michael A.; Mathur, Arvind; Zhao, Qihong; Salter-Cid, Luisa M.; Carter, Percy H.; Dhar, T.G. Murali

Research Organization:: Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)

Sponsoring Organization:: DOE - Office Of Science; INDUSTRY

OSTI ID:: 1833652

Journal Information:: Bioorg. Med. Chem. Lett., Journal Name: Bioorg. Med. Chem. Lett. Journal Issue: (17) Vol. 30

Country of Publication:: United States

Language:: ENGLISH

References (13)

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The psoriasis drugs market Rizvi, Salman; Chaudhari, Kritika; Syed, Basharut A. Nature Reviews Drug Discovery, Vol. 14, Issue 11 https://doi.org/10.1038/nrd4763	journal	October 2015
Interleukin-17A: a unique pathway in immune-mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis Kirkham, Bruce W.; Kavanaugh, Arthur; Reich, Kristian Immunology, Vol. 141, Issue 2 https://doi.org/10.1111/imm.12142	journal	January 2014
Targeting the Th17 pathway in psoriasis Elloso, M. Merle; Gomez-Angelats, Mireia; Fourie, Anne M. Journal of Leukocyte Biology, Vol. 92, Issue 6 https://doi.org/10.1189/jlb.0212101	journal	December 2012
Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment Prinz, Immo; Sandrock, Inga; Mrowietz, Ulrich Journal of Experimental Medicine, Vol. 217, Issue 1 https://doi.org/10.1084/jem.20191397	journal	November 2019
Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Fauber, Benjamin P.; Magnuson, Steven Journal of Medicinal Chemistry, Vol. 57, Issue 14 https://doi.org/10.1021/jm401901d	journal	February 2014
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists Duan, James J. -W.; Lu, Zhonghui; Jiang, Bin ACS Medicinal Chemistry Letters, Vol. 10, Issue 3 https://doi.org/10.1021/acsmedchemlett.9b00010	journal	February 2019
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism Jetten, Anton M. Nuclear Receptor Signaling, Vol. 7, Issue 1 https://doi.org/10.1621/nrs.07003	journal	January 2009
The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings Martin, David A.; Towne, Jennifer E.; Kricorian, Gregory Journal of Investigative Dermatology, Vol. 133, Issue 1 https://doi.org/10.1038/jid.2012.194	journal	January 2013
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present) Sun, Nannan; Guo, Huimin; Wang, Yonghui Expert Opinion on Therapeutic Patents, Vol. 29, Issue 9 https://doi.org/10.1080/13543776.2019.1655541	journal	August 2019

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