Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-m

Journal Article · · J. Med. Chem.

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; UNIVERSITY
OSTI ID:
1832569
Journal Information:
J. Med. Chem., Journal Name: J. Med. Chem. Journal Issue: (20) Vol. 64
Country of Publication:
United States
Language:
ENGLISH

References (30)

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia journal April 2003
SHP2 forecast for the immune system: fog gradually clearing journal March 2006
Rational design of allosteric-inhibition sites in classical protein tyrosine phosphatases journal June 2015
SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo journal May 2018
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases journal June 2016
Dual Allosteric Inhibition of SHP2 Phosphatase journal January 2018
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase journal May 2018
RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers journal August 2018
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors journal January 2019
Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2 journal December 2017
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor journal July 2016
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application journal May 2020
Myeloid-Specific Disruption of Tyrosine Phosphatase Shp2 Promotes Alternative Activation of Macrophages and Predisposes Mice to Pulmonary Fibrosis journal August 2014
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models journal July 2018
Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis journal April 2009
Allosteric Inhibition of SHP2 Stimulates Antitumor Immunity by Transforming the Immunosuppressive Environment journal April 2020
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction journal January 2014
Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells journal September 2011
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor journal January 2018
PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment journal December 2014
Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors journal January 2019
Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations journal June 2014
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 journal May 2012
Allosteric inhibition of protein tyrosine phosphatase 1B journal July 2004
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase journal October 2006
Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia journal October 2014
The PDL1-PD1 Axis Converts Human T H 1 Cells into Regulatory T Cells journal November 2011
Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia journal December 2004
Protein tyrosine phosphatase SHP-2: A proto-oncogene product that promotes Ras activation journal October 2009
The role of Shp2 (PTPN11) in cancer journal February 2007

Similar Records

Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phe
Journal Article · Tue Sep 01 00:00:00 EDT 2020 · Bioorg. Med. Chem. Lett. · OSTI ID:1833652

Discovery of (3S,4S)-3-methyl-3-(4-fluorophenyl)-4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxyprop-2-yl)phe
Journal Article · Tue Sep 01 00:00:00 EDT 2020 · Bioorg. Med. Chem. Lett. · OSTI ID:1837292

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor
Journal Article · Tue Nov 19 23:00:00 EST 2013 · J. Med. Chem. · OSTI ID:1107387

Related Subjects