Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products

Azubuike, Christopher C.; Allemann, Marco N.; Michener, Joshua K.

doi:10.1016/j.mib.2021.10.014

Microbial assimilation of lignin-derived aromatic compounds and conversion to value-added products

Journal Article · Thu Nov 11 00:00:00 EST 2021 · Current Opinion in Microbiology

DOI:https://doi.org/10.1016/j.mib.2021.10.014· OSTI ID:1831616

^[1]; Allemann, Marco N. ^[1]; ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Lignin is an abundant and sustainable source of aromatic compounds that can be converted to value-added products. However, lignin is underutilized, since depolymerization produces a complex mixture of aromatic compounds that is difficult to convert to a single product. Microbial conversion of mixed aromatic substrates provides a potential solution to this conversion challenge. Recent advances have expanded the range of lignin-derived aromatic substrates that can be assimilated and demonstrated efficient conversion via central metabolism to new potential products. Here, the development of additional non-model microbial hosts and genetic tools for these hosts have accelerated engineering efforts. However, yields with real depolymerized lignin are still low, and additional work will be required to achieve viable conversion processes.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1831616

Alternate ID(s):: OSTI ID: 1829925

Journal Information:: Current Opinion in Microbiology, Journal Name: Current Opinion in Microbiology Vol. 65; ISSN 1369-5274

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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