Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis

Martien, Julia I.; Trujillo, Edna A.; Jacobson, Tyler B.; Tatli, Mehmet; Hebert, Alexander S.; Stevenson, David M.; Coon, Joshua J.; Amador-Noguez, Daniel; Vickers, ed., Claudia

doi:10.1128/mSystems.00987-21

Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis

Journal Article · Tue Dec 21 04:00:00 EST 2021 · mSystems

DOI:https://doi.org/10.1128/mSystems.00987-21· OSTI ID:1830455

^[1]; ^[2]; ^[1]; Tatli, Mehmet ^[1]; ^[3]; Stevenson, David M. ^[1]; ^[4]; ^[1]; Vickers, ed., Claudia

DOE Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison, Wisconsin, USA, Department of Bacteriology, University of Wisconsin–Madison, Madison, Wisconsin, USA
Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA, National Center for Quantitative Biology of Complex Systems, University of Wisconsin–Madison, Madison, Wisconsin, USA
DOE Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison, Wisconsin, USA, Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA
DOE Great Lakes Bioenergy Research Center, University of Wisconsin–Madison, Madison, Wisconsin, USA, Department of Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA, National Center for Quantitative Biology of Complex Systems, University of Wisconsin–Madison, Madison, Wisconsin, USA, Department of Biomolecular Chemistry, University of Wisconsin–Madison, Madison, Wisconsin, USA, Morgridge Institute for Research, Madison, Wisconsin, USA

Biofuels and bioproducts have the potential to serve as environmentally sustainable replacements for petroleum-derived fuels and commodity molecules. Advanced fuels such as higher alcohols and isoprenoids are more suitable gasoline replacements than bioethanol.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018409; FC02-07ER64494; SC0018998

OSTI ID:: 1830455

Alternate ID(s):: OSTI ID: 1904707

Journal Information:: mSystems, Journal Name: mSystems Journal Issue: 6 Vol. 6; ISSN 2379-5077

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

References (110)

LC‐MS Data Processing with MAVEN: A Metabolomic Analysis and Visualization Engine Clasquin, Michelle F.; Melamud, Eugene; Rabinowitz, Joshua D. Current Protocols in Bioinformatics, Vol. 37, Issue 1 https://doi.org/10.1002/0471250953.bi1411s37	journal	March 2012
Adaptation yields a highly efficient xylose-fermenting Zymomonas mobilis strain Agrawal, Manoj; Mao, Zichao; Chen, Rachel Ruizhen Biotechnology and Bioengineering, Vol. 108, Issue 4 https://doi.org/10.1002/bit.23021	journal	December 2010
Inhibition analysis of inhibitors derived from lignocellulose pretreatment on the metabolic activity of Zymomonas mobilis biofilm and planktonic cells and the proteomic responses Todhanakasem, Tatsaporn; Yodsanga, Supanika; Sowatad, Apinya Biotechnology and Bioengineering, Vol. 115, Issue 1 https://doi.org/10.1002/bit.26449	journal	October 2017
The pleiotropic nature of symbiotic regulatory mutants: Bradyrhizobium japonicum nifA gene is involved in control of nif gene expression and formation of determinate symbiosis Fischer, Hans-Martin; Alvarez-Morales, Ariel; Hennecke, Hauke The EMBO Journal, Vol. 5, Issue 6 https://doi.org/10.1002/j.1460-2075.1986.tb04342.x	journal	June 1986
Kinetic control of ethanol production by Zymomonas mobilis Jones, ColinW.; Doelle, HorstW. Applied Microbiology and Biotechnology, Vol. 35, Issue 1 https://doi.org/10.1007/BF00180626	journal	April 1991
Purification of two alcohol dehydrogenases from Zymomonas mobilis and their properties Kinoshita, Shinichi; Kakizono, Toshihide; Kadota, Keiichi Applied Microbiology and Biotechnology, Vol. 22, Issue 4 https://doi.org/10.1007/BF00252025	journal	August 1985
Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum Fitzmaurice, Wayne P.; Saari, Leonard L.; Lowery, Robert G. Molecular and General Genetics MGG, Vol. 218, Issue 2 https://doi.org/10.1007/BF00331287	journal	August 1989
Ethanol production by Zymomonas and Saccharomyces, advantages and disadvantages Karsch, Thomas; Stahl, Ulf; Esser, Karl European Journal of Applied Microbiology and Biotechnology, Vol. 18, Issue 6 https://doi.org/10.1007/BF00504750	journal	November 1983
Kinetics of alcohol production by zymomonas mobilis at high sugar concentrations Rogers, P. L.; Lee, Kye Joon; Tribe, D. E. Biotechnology Letters, Vol. 1, Issue 4 https://doi.org/10.1007/BF01388142	journal	April 1979
Glutamate synthase: a complex iron-sulfur flavoprotein Vanoni, M. A.; Curti, B. Cellular and Molecular Life Sciences (CMLS), Vol. 55, Issue 4 https://doi.org/10.1007/s000180050319	journal	April 1999
Transcriptional analysis of adaptation to high glucose concentrations in Zymomonas mobilis Zhang, Kun; Shao, Huanhuan; Cao, Qinghua Applied Microbiology and Biotechnology, Vol. 99, Issue 4 https://doi.org/10.1007/s00253-014-6342-y	journal	January 2015
The ecology of Zymomonas: a review Weir, Patrick M. Folia Microbiologica, Vol. 61, Issue 5 https://doi.org/10.1007/s12223-016-0447-x	journal	January 2016
Characterization of the two alcohol dehydrogenases of Zymomonas mobilis Wills, Christopher; Kratofil, Paul; Londo, David Archives of Biochemistry and Biophysics, Vol. 210, Issue 2 https://doi.org/10.1016/0003-9861(81)90245-9	journal	September 1981
Glutamate dehydrogenase from Escherichia coli: Induction, purification and properties of the enzyme Veronese, Francesco M.; Boccu, Enrico; Conventi, Luciano Biochimica et Biophysica Acta (BBA) - Enzymology, Vol. 377, Issue 2 https://doi.org/10.1016/0005-2744(75)90304-6	journal	February 1975
In vivo studies on the interaction of RNA polymerase-σ54 with the Klebsiella pneumoniae and Rhizobium meliloti nifH promoters Morett, Enrique; Buck, Martin Journal of Molecular Biology, Vol. 210, Issue 1 https://doi.org/10.1016/0022-2836(89)90291-X	journal	November 1989
The fermentation kinetics of ethanol production by Zymomonas mobilis Lee, K. J.; Rogers, P. L. The Chemical Engineering Journal, Vol. 27, Issue 2 https://doi.org/10.1016/0300-9467(83)80067-7	journal	October 1983
Metabolic flux analysis and fluxomics-driven determination of reaction free energy using multiple isotopes Xu, Jimmy; Martien, Julia; Gilbertson, Cole Current Opinion in Biotechnology, Vol. 64 https://doi.org/10.1016/j.copbio.2020.02.018	journal	August 2020
Respiratory behaviour of a Zymomonas mobilis adhB::kan ^r mutant supports the hypothesis of two alcohol dehydrogenase isoenzymes catalysing opposite reactions Kalnenieks, U.; Galinina, N.; Toma, M. M. FEBS Letters, Vol. 580, Issue 21 https://doi.org/10.1016/j.febslet.2006.08.034	journal	August 2006
Horizontal gene transfer and archaeal origin of deoxyhypusine synthase homologous genes in bacteria Brochier, Céline; López-Garcı́a, Purificación; Moreira, David Gene, Vol. 330 https://doi.org/10.1016/j.gene.2004.01.018	journal	April 2004
Simultaneous nitrogen fixation and ethanol production by Zymomonas mobilis Palamae, Suriya; Choorit, Wanna; Chatsungnoen, Tawan Journal of Biotechnology, Vol. 314-315 https://doi.org/10.1016/j.jbiotec.2020.03.016	journal	May 2020
Reduced activity of glutamine synthetase in Rhodospirillum rubrum mutants lacking the adenylyltransferase GlnE Jonsson, Anders; Nordlund, Stefan; Teixeira, Pedro Filipe Research in Microbiology, Vol. 160, Issue 8 https://doi.org/10.1016/j.resmic.2009.09.003	journal	October 2009
Engineering Zymomonas mobilis for Robust Cellulosic Ethanol Production Xia, Juan; Yang, Yongfu; Liu, Chen-Guang Trends in Biotechnology, Vol. 37, Issue 9 https://doi.org/10.1016/j.tibtech.2019.02.002	journal	September 2019
Elementary metabolite units (EMU): A novel framework for modeling isotopic distributions Antoniewicz, Maciek R.; Kelleher, Joanne K.; Stephanopoulos, Gregory Metabolic Engineering, Vol. 9, Issue 1 https://doi.org/10.1016/j.ymben.2006.09.001	journal	January 2007
COMPLETE-MFA: Complementary parallel labeling experiments technique for metabolic flux analysis Leighty, Robert W.; Antoniewicz, Maciek R. Metabolic Engineering, Vol. 20 https://doi.org/10.1016/j.ymben.2013.08.006	journal	November 2013
Advances and prospects in metabolic engineering of Zymomonas mobilis Wang, Xia; He, Qiaoning; Yang, Yongfu Metabolic Engineering, Vol. 50 https://doi.org/10.1016/j.ymben.2018.04.001	journal	November 2018
2H and 13C metabolic flux analysis elucidates in vivo thermodynamics of the ED pathway in Zymomonas mobilis Jacobson, Tyler B.; Adamczyk, Paul A.; Stevenson, David M. Metabolic Engineering, Vol. 54 https://doi.org/10.1016/j.ymben.2019.05.006	journal	July 2019
Regulated redirection of central carbon flux enhances anaerobic production of bioproducts in Zymomonas mobilis Liu, Yang; Ghosh, Indro Neil; Martien, Julia Metabolic Engineering, Vol. 61 https://doi.org/10.1016/j.ymben.2020.06.005	journal	September 2020
Metabolomic Analysis via Reversed-Phase Ion-Pairing Liquid Chromatography Coupled to a Stand Alone Orbitrap Mass Spectrometer Lu, Wenyun; Clasquin, Michelle F.; Melamud, Eugene Analytical Chemistry, Vol. 82, Issue 8 https://doi.org/10.1021/ac902837x	journal	April 2010
Improved Precursor Characterization for Data-Dependent Mass Spectrometry Hebert, Alexander S.; Thöing, Christian; Riley, Nicholas M. Analytical Chemistry, Vol. 90, Issue 3 https://doi.org/10.1021/acs.analchem.7b04808	journal	January 2018
Ultra-High Pressure (>30,000 psi) Packing of Capillary Columns Enhancing Depth of Shotgun Proteomic Analyses Shishkova, Evgenia; Hebert, Alexander S.; Westphall, Michael S. Analytical Chemistry, Vol. 90, Issue 19 https://doi.org/10.1021/acs.analchem.8b02766	journal	September 2018
Biosynthesis of Nitrogenase Cofactors Burén, Stefan; Jiménez-Vicente, Emilio; Echavarri-Erasun, Carlos Chemical Reviews, Vol. 120, Issue 12 https://doi.org/10.1021/acs.chemrev.9b00489	journal	January 2020
Kinetic mechanism of Escherichia coli glutamine synthetase Meek, Thomas D.; Villafranca, Joseph J. Biochemistry, Vol. 19, Issue 24 https://doi.org/10.1021/bi00565a008	journal	November 1980
Metabolomics‐driven quantitative analysis of ammonia assimilation in E. coli Yuan, Jie; Doucette, Christopher D.; Fowler, William U. Molecular Systems Biology, Vol. 5, Issue 1 https://doi.org/10.1038/msb.2009.60	journal	January 2009
Need‐based activation of ammonium uptake in Escherichia coli Kim, Minsu; Zhang, Zhongge; Okano, Hiroyuki Molecular Systems Biology, Vol. 8, Issue 1 https://doi.org/10.1038/msb.2012.46	journal	January 2012
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification Cox, Jürgen; Mann, Matthias Nature Biotechnology, Vol. 26, Issue 12 https://doi.org/10.1038/nbt.1511	journal	November 2008
Improved genome annotation for Zymomonas mobilis Yang, Shihui; Pappas, Katherine M.; Hauser, Loren J. Nature Biotechnology, Vol. 27, Issue 10 https://doi.org/10.1038/nbt1009-893	journal	October 2009
The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4 Seo, Jeong-Sun; Chong, Hyonyong; Park, Hyun Seok Nature Biotechnology, Vol. 23, Issue 1 https://doi.org/10.1038/nbt1045	journal	December 2004
α-ketoglutarate coordinates carbon and nitrogen utilization via enzyme I inhibition Doucette, Christopher D.; Schwab, David J.; Wingreen, Ned S. Nature Chemical Biology, Vol. 7, Issue 12 https://doi.org/10.1038/nchembio.685	journal	October 2011
Genetic regulation of biological nitrogen fixation Dixon, Ray; Kahn, Daniel Nature Reviews Microbiology, Vol. 2, Issue 8 https://doi.org/10.1038/nrmicro954	journal	August 2004
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield Park, Junyoung O.; Tanner, Lukas B.; Wei, Monica H. Nature Chemical Biology, Vol. 15, Issue 10 https://doi.org/10.1038/s41589-019-0364-9	journal	September 2019
Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories Li, Meijie; Hou, Feifei; Wu, Tong Natural Product Reports, Vol. 37, Issue 1 https://doi.org/10.1039/c9np00016j	journal	January 2020
Biosynthesis of polyamines and polyamine-containing molecules Michael, Anthony J. Biochemical Journal, Vol. 473, Issue 15 https://doi.org/10.1042/BCJ20160185	journal	July 2016
Glycolytic strategy as a tradeoff between energy yield and protein cost Flamholz, A.; Noor, E.; Bar-Even, A. Proceedings of the National Academy of Sciences, Vol. 110, Issue 24 https://doi.org/10.1073/pnas.1215283110	journal	April 2013
N ₂ gas is an effective fertilizer for bioethanol production by Zymomonas mobilis Kremer, Timothy A.; LaSarre, Breah; Posto, Amanda L. Proceedings of the National Academy of Sciences, Vol. 112, Issue 7 https://doi.org/10.1073/pnas.1420663112	journal	February 2015
Polyamines protect Escherichia coli cells from the toxic effect of oxygen Chattopadhyay, M. K.; Tabor, C. W.; Tabor, H. Proceedings of the National Academy of Sciences, Vol. 100, Issue 5 https://doi.org/10.1073/pnas.2627990100	journal	February 2003
Regulation of glutamine synthetase. 8. ATP: glutamine synthetase adenylyltransferase, an enzyme that catalyzes alterations in the regulatory properties of glutamine synthetase. Kingdon, H. S.; Shapiro, B. M.; Stadtman, E. R. Proceedings of the National Academy of Sciences, Vol. 58, Issue 4 https://doi.org/10.1073/pnas.58.4.1703	journal	October 1967
Chemomechanical Coupling without ATP: The Source of Energy for Motility and Chemotaxis in Bacteria Larsen, S. H.; Adler, J.; Gargus, J. J. Proceedings of the National Academy of Sciences, Vol. 71, Issue 4 https://doi.org/10.1073/pnas.71.4.1239	journal	April 1974
Physical map of chromosomal nitrogen fixation (nif) genes of Klebsiella pneumoniae Riedel, G. E.; Ausubel, F. M.; Cannon, F. C. Proceedings of the National Academy of Sciences, Vol. 76, Issue 6 https://doi.org/10.1073/pnas.76.6.2866	journal	June 1979
Covalent modification of the iron protein of nitrogenase from Rhodospirillum rubrum by adenosine diphosphoribosylation of a specific arginine residue. Pope, M. R.; Murrell, S. A.; Ludden, P. W. Proceedings of the National Academy of Sciences, Vol. 82, Issue 10 https://doi.org/10.1073/pnas.82.10.3173	journal	May 1985
Evolution and Multifarious Horizontal Transfer of an Alternative Biosynthetic Pathway for the Alternative Polyamine sym-Homospermidine* Shaw, Frances L.; Elliott, Katherine A.; Kinch, Lisa N. Journal of Biological Chemistry, Vol. 285, Issue 19 https://doi.org/10.1074/jbc.M110.107219	journal	May 2010
Polyamines Are Critical for the Induction of the Glutamate Decarboxylase-dependent Acid Resistance System in Escherichia coli Chattopadhyay, Manas K.; Tabor, Herbert Journal of Biological Chemistry, Vol. 288, Issue 47 https://doi.org/10.1074/jbc.M113.510552	journal	November 2013
The One Hour Yeast Proteome Hebert, Alexander S.; Richards, Alicia L.; Bailey, Derek J. Molecular & Cellular Proteomics, Vol. 13, Issue 1 https://doi.org/10.1074/mcp.M113.034769	journal	October 2013
INCA: a computational platform for isotopically non-stationary metabolic flux analysis Young, J. D. Bioinformatics, Vol. 30, Issue 9 https://doi.org/10.1093/bioinformatics/btu015	journal	January 2014
Polyamine biosynthesis and biological roles in rhizobia Becerra-Rivera, Victor A.; Dunn, Michael F. FEMS Microbiology Letters, Vol. 366, Issue 7 https://doi.org/10.1093/femsle/fnz084	journal	April 2019
2016 update of the PRIDE database and its related tools Vizcaíno, Juan Antonio; Csordas, Attila; del-Toro, Noemi Nucleic Acids Research, Vol. 44, Issue 22 https://doi.org/10.1093/nar/gkw880	journal	September 2016
PII signal transduction proteins: pivotal players in post-translational control of nitrogenase activity Huergo, L. F.; Pedrosa, F. O.; Muller-Santos, M. Microbiology, Vol. 158, Issue 1 https://doi.org/10.1099/mic.0.049783-0	journal	December 2011
Identification and functional characterization of NifA variants that are independent of GlnB activation in the photosynthetic bacterium Rhodospirillum rubrum Zou, Xiaoxiao; Zhu, Yu; Pohlmann, Edward L. Microbiology, Vol. 154, Issue 9 https://doi.org/10.1099/mic.0.2008/019406-0	journal	September 2008
A Mutant Impaired in the Production of Plastome-Encoded Proteins Uncovers a Mechanism for the Homeostasis of Isoprenoid Biosynthetic Enzymes in Arabidopsis Plastids Flores-Pérez, Úrsula; Sauret-Güeto, Susanna; Gas, Elisabet The Plant Cell, Vol. 20, Issue 5 https://doi.org/10.1105/tpc.108.058768	journal	May 2008
Zymomonas mobilis as a model system for production of biofuels and biochemicals Yang, Shihui; Fei, Qiang; Zhang, Yaoping Microbial Biotechnology, Vol. 9, Issue 6 https://doi.org/10.1111/1751-7915.12408	journal	September 2016
NifB and NifEN protein levels are regulated by ClpX2 under nitrogen fixation conditions in Azotobacter vinelandii: ClpX2 regulation of NifB and NifEN Martínez-Noël, Giselle; Curatti, Leonardo; Hernandez, Jose A. Molecular Microbiology, Vol. 79, Issue 5 https://doi.org/10.1111/j.1365-2958.2011.07540.x	journal	January 2011
The Glutamine Synthetase from Azotobacter vinelandii: Purification, Characterization, Regulation and Localization Kleinschmidt, Jurgen A.; Kleiner, Diethelm European Journal of Biochemistry, Vol. 89, Issue 1 https://doi.org/10.1111/j.1432-1033.1978.tb20895.x	journal	August 1978
The two alcohol dehydrogenases of Zymomonas mobilis. Purification by differential dye ligand chromatography, molecular characterisation and physiological roles Neale, Alan D.; Scopes, Robert K.; Kelly, Janice M. European Journal of Biochemistry, Vol. 154, Issue 1 https://doi.org/10.1111/j.1432-1033.1986.tb09366.x	journal	January 1986
Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases Sandmeier, Erika; Hale, Terence I.; Christen, Philipp European Journal of Biochemistry, Vol. 221, Issue 3 https://doi.org/10.1111/j.1432-1033.1994.tb18816.x	journal	May 1994
Carbohydrate metabolism in Zymomonas mobilis : a catabolic highway with some scenic routes Sprenger, Georg A. FEMS Microbiology Letters, Vol. 145, Issue 3 https://doi.org/10.1111/j.1574-6968.1996.tb08593.x	journal	December 1996
Recent developments on the regulation and structure of glutamine synthetase enzymes from selected bacterial groups Woods, David R.; Reid, Sharon J. FEMS Microbiology Reviews, Vol. 11, Issue 4 https://doi.org/10.1111/j.1574-6976.1993.tb00001.x	journal	August 1993
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing Benjamini, Yoav; Hochberg, Yosef Journal of the Royal Statistical Society: Series B (Methodological), Vol. 57, Issue 1 https://doi.org/10.1111/j.2517-6161.1995.tb02031.x	journal	January 1995
Homospermidine biosynthesis in the cyanobacterium Anabaena requires a deoxyhypusine synthase homologue and is essential for normal diazotrophic growth Burnat, Mireia; Li, Bin; Kim, Sok Ho Molecular Microbiology, Vol. 109, Issue 6 https://doi.org/10.1111/mmi.14006	journal	September 2018
Metabolic Engineering of a Pentose Metabolism Pathway in Ethanologenic Zymomonas mobilis Zhang, M.; Eddy, C.; Deanda, K. Science, Vol. 267, Issue 5195 https://doi.org/10.1126/science.267.5195.240	journal	January 1995
Environmental Dependence of Stationary-Phase Metabolism in Bacillus subtilis and Escherichia coli Chubukov, V.; Sauer, U. Applied and Environmental Microbiology, Vol. 80, Issue 9 https://doi.org/10.1128/AEM.00061-14	journal	February 2014
The Rnf Complex Is an Energy-Coupled Transhydrogenase Essential To Reversibly Link Cellular NADH and Ferredoxin Pools in the Acetogen Acetobacterium woodii Westphal, Lars; Wiechmann, Anja; Baker, Jonathan Journal of Bacteriology, Vol. 200, Issue 21 https://doi.org/10.1128/JB.00357-18	journal	August 2018
Electron Transfer to Nitrogenase in Different Genomic and Metabolic Backgrounds Poudel, Saroj; Colman, Daniel R.; Fixen, Kathryn R. Journal of Bacteriology, Vol. 200, Issue 10 https://doi.org/10.1128/JB.00757-17	journal	February 2018
Pathway Choice in Glutamate Synthesis in Escherichia coli Helling, Robert B. Journal of Bacteriology, Vol. 180, Issue 17 https://doi.org/10.1128/JB.180.17.4571-4575.1998	journal	September 1998
Nitrogen Assimilation in Escherichia coli: Putting Molecular Data into a Systems Perspective van Heeswijk, W. C.; Westerhoff, H. V.; Boogerd, F. C. Microbiology and Molecular Biology Reviews, Vol. 77, Issue 4 https://doi.org/10.1128/MMBR.00025-13	journal	December 2013
Production of beta-carotene in Zymomonas mobilis and Agrobacterium tumefaciens by introduction of the biosynthesis genes from Erwinia uredovora. Misawa, N.; Yamano, S.; Ikenaga, H. Applied and Environmental Microbiology, Vol. 57, Issue 6 https://doi.org/10.1128/aem.57.6.1847-1849.1991	journal	January 1991
The biology of Zymomonas. Swings, J.; De Ley, J. Bacteriological Reviews, Vol. 41, Issue 1 https://doi.org/10.1128/br.41.1.1-46.1977	journal	January 1977
nifV-dependent, low-molecular-weight factor required for in vitro synthesis of iron-molybdenum cofactor of nitrogenase. Hoover, T. R.; Shah, V. K.; Roberts, G. P. Journal of Bacteriology, Vol. 167, Issue 3 https://doi.org/10.1128/jb.167.3.999-1003.1986	journal	September 1986
Amino acid concentrations in Rhodospirillum rubrum during expression and switch-off of nitrogenase activity Kanemoto, R. H.; Ludden, P. W. Journal of Bacteriology, Vol. 169, Issue 7 https://doi.org/10.1128/jb.169.7.3035-3043.1987	journal	July 1987
Homocitrate cures the NifV- phenotype in Klebsiella pneumoniae Hoover, T. R.; Imperial, J.; Ludden, P. W. Journal of Bacteriology, Vol. 170, Issue 4 https://doi.org/10.1128/jb.170.4.1978-1979.1988	journal	April 1988
Physical and genetic map of the major nif gene cluster from Azotobacter vinelandii. Jacobson, M. R.; Brigle, K. E.; Bennett, L. T. Journal of Bacteriology, Vol. 171, Issue 2 https://doi.org/10.1128/jb.171.2.1017-1027.1989	journal	February 1989
Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism Barnell, W. O.; Yi, K. C.; Conway, T. Journal of Bacteriology, Vol. 172, Issue 12 https://doi.org/10.1128/jb.172.12.7227-7240.1990	journal	December 1990
Metabolic Remodeling during Biofilm Development of Bacillus subtilis Pisithkul, Tippapha; Schroeder, Jeremy W.; Trujillo, Edna A. mBio, Vol. 10, Issue 3 https://doi.org/10.1128/mBio.00623-19	journal	May 2019
Systems-Level Analysis of Oxygen Exposure in Zymomonas mobilis : Implications for Isoprenoid Production Martien, Julia I.; Hebert, Alexander S.; Stevenson, David M. mSystems, Vol. 4, Issue 1 https://doi.org/10.1128/mSystems.00284-18	journal	February 2019
In Vivo Thermodynamic Analysis of Glycolysis in Clostridium thermocellum and Thermoanaerobacterium saccharolyticum Using ¹³ C and ² H Tracers Jacobson, Tyler B.; Korosh, Travis K.; Stevenson, David M. mSystems, Vol. 5, Issue 2 https://doi.org/10.1128/mSystems.00736-19	journal	March 2020
Biosynthesis and metabolism of arginine in bacteria Cunin, R.; Glansdorff, N.; Piérard, A. Microbiological Reviews, Vol. 50, Issue 3 https://doi.org/10.1128/mr.50.3.314-352.1986	journal	September 1986
Nitrogen control in bacteria Merrick, M. J.; Edwards, R. A. Microbiological Reviews, Vol. 59, Issue 4 https://doi.org/10.1128/mr.59.4.604-622.1995	journal	December 1995
Polyamine distribution patterns serve as a phenotypic marker in the chemotaxonomy of the Proteobacteria Hamana, Koei; Matsuzaki, Shigeru Canadian Journal of Microbiology, Vol. 39, Issue 3 https://doi.org/10.1139/m93-043	journal	March 1993
Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis Zhao, Lishan; Chang, Wei-chen; Xiao, Youli Annual Review of Biochemistry, Vol. 82, Issue 1 https://doi.org/10.1146/annurev-biochem-052010-100934	journal	June 2013
Biosynthesis of the Iron-Molybdenum Cofactor of Nitrogenase Rubio, Luis M.; Ludden, Paul W. Annual Review of Microbiology, Vol. 62, Issue 1 https://doi.org/10.1146/annurev.micro.62.081307.162737	journal	October 2008
Impact of assimilable nitrogen availability in glucose uptake kinetics in Saccharomyces cerevisiae during alcoholic fermentation Palma, Margarida; Madeira, Sara Cordeiro; Mendes-Ferreira, Ana Microbial Cell Factories, Vol. 11, Issue 1 https://doi.org/10.1186/1475-2859-11-99	journal	July 2012
The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies Lee, Kyung; Park, Jong; Kim, Tae Microbial Cell Factories, Vol. 9, Issue 1 https://doi.org/10.1186/1475-2859-9-94	journal	January 2010
Transcriptome profiling of Zymomonas mobilis under ethanol stress He, Ming-xiong; Wu, Bo; Shui, Zong-xia Biotechnology for Biofuels, Vol. 5, Issue 1 https://doi.org/10.1186/1754-6834-5-75	journal	January 2012
Zymomonas mobilis: a novel platform for future biorefineries He, Ming; Wu, Bo; Qin, Han Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-101	journal	January 2014
Improving xylose utilization by recombinant Zymomonas mobilis strain 8b through adaptation using 2-deoxyglucose Mohagheghi, Ali; Linger, Jeff; Smith, Holly Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-19	journal	January 2014
ElemCor: accurate data analysis and enrichment calculation for high-resolution LC-MS stable isotope labeling experiments Du, Di; Tan, Lin; Wang, Yumeng BMC Bioinformatics, Vol. 20, Issue 1 https://doi.org/10.1186/s12859-019-2669-9	journal	February 2019
Insights into acetate toxicity in Zymomonas mobilis8b using different substrates Yang, Shihui; Franden, Mary Ann; Brown, Steven D. Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/s13068-014-0140-8	journal	September 2014
Metabolic engineering of Zymomonas mobilis for 2,3-butanediol production from lignocellulosic biomass sugars Yang, Shihui; Mohagheghi, Ali; Franden, Mary Ann Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-016-0606-y	journal	September 2016
Complete genome sequence and the expression pattern of plasmids of the model ethanologen Zymomonas mobilis ZM4 and its xylose-utilizing derivatives 8b and 2032 Yang, Shihui; Vera, Jessica M.; Grass, Jeff Biotechnology for Biofuels, Vol. 11, Issue 1 https://doi.org/10.1186/s13068-018-1116-x	journal	May 2018
Development and characterization of acidic-pH-tolerant mutants of Zymomonas mobilis through adaptation and next-generation sequencing-based genome resequencing and RNA-Seq Yang, Qing; Yang, Yongfu; Tang, Ying Biotechnology for Biofuels, Vol. 13, Issue 1 https://doi.org/10.1186/s13068-020-01781-1	journal	August 2020
Metabolic engineering of Zymomonas mobilis for anaerobic isobutanol production Qiu, Mengyue; Shen, Wei; Yan, Xiongyin Biotechnology for Biofuels, Vol. 13, Issue 1 https://doi.org/10.1186/s13068-020-1654-x	journal	January 2020
Progress and perspective on lignocellulosic hydrolysate inhibitor tolerance improvement in Zymomonas mobilis Yang, Yongfu; Hu, Mimi; Tang, Ying Bioresources and Bioprocessing, Vol. 5, Issue 1 https://doi.org/10.1186/s40643-018-0193-9	journal	February 2018
Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism Noor, Elad; Bar-Even, Arren; Flamholz, Avi PLoS Computational Biology, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pcbi.1003483	journal	February 2014
Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria Fruzangohar, Mario; Ebrahimie, Esmaeil; Ogunniyi, Abiodun D. PLoS ONE, Vol. 8, Issue 3 https://doi.org/10.1371/journal.pone.0058759	journal	March 2013
Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels and Coproducts: 2018 Biochemical Design Case Update; Biochemical Deconstruction and Conversion of Biomass to Fuels and Products via Integrated Biorefinery Pathways Davis, Ryan E.; Grundl, Nicholas J.; Tao, Ling https://doi.org/10.2172/1483234	report	November 2018
Glutamine signalling in bacteria Forchhammer, Karl Frontiers in Bioscience, Vol. 12, Issue 1 https://doi.org/10.2741/2069	journal	January 2007
Nitrogen Fixation and Molecular Oxygen: Comparative Genomic Reconstruction of Transcription Regulation in Alphaproteobacteria Tsoy, Olga V.; Ravcheev, Dmitry A.; Čuklina, Jelena Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.01343	journal	August 2016
Genome Wide Phosphoproteome Analysis of Zymomonas mobilis Under Anaerobic, Aerobic, and N2-Fixing Conditions Tatli, Mehmet; Hebert, Alexander S.; Coon, Joshua J. Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.01986	journal	September 2019
Improvement of Acetaldehyde Production in Zymomonas mobilis by Engineering of Its Aerobic Metabolism Kalnenieks, Uldis; Balodite, Elina; Strähler, Steffi Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02533	journal	November 2019
Multiomic Fermentation Using Chemically Defined Synthetic Hydrolyzates Revealed Multiple Effects of Lignocellulose-Derived Inhibitors on Cell Physiology and Xylose Utilization in Zymomonas mobilis Zhang, Yaoping; Vera, Jessica M.; Xie, Dan Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.02596	journal	November 2019
Transcriptomic Profiles of Zymomonas mobilis 8b to Furfural Acute and Long-Term Stress in Both Glucose and Xylose Conditions Yang, Shihui; Franden, Mary Ann; Wang, Xia Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.00013	journal	January 2020
The Quorum Sensing Auto-Inducer 2 (AI-2) Stimulates Nitrogen Fixation and Favors Ethanol Production over Biomass Accumulation in Zymomonas mobilis Alencar, Valquíria Campos; Silva, Juliana de Fátima dos Santos; Vilas Boas, Renata Ozelami International Journal of Molecular Sciences, Vol. 22, Issue 11 https://doi.org/10.3390/ijms22115628	journal	May 2021

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