A Processable Shape Memory Polymer System for Biomedical Applications

Hearon, Keith; Wierzbicki, Mark A.; Nash, Landon D.; Landsman, Todd L.; Laramy, Christine; Lonnecker, Alexander T.; Gibbons, Michael C.; Ur, Sarah; Cardinal, Kristen O.; Wilson, Thomas S.; Wooley, Karen L.; Maitland, Duncan J.

doi:10.1002/adhm.201500156

Title: A Processable Shape Memory Polymer System for Biomedical Applications

Journal Article · Thu Apr 30 00:00:00 EDT 2015 · Advanced Healthcare Materials

DOI:https://doi.org/10.1002/adhm.201500156· OSTI ID:1828129

Hearon, Keith ^[1]; Wierzbicki, Mark A. ^[1]; Nash, Landon D. ^[1]; Landsman, Todd L. ^[1]; Laramy, Christine ^[1]; Lonnecker, Alexander T. ^[1]; Gibbons, Michael C. ^[2]; Ur, Sarah ^[2]; Cardinal, Kristen O. ^[2]; Wilson, Thomas S. ^[3]; Wooley, Karen L. ^[1]; Maitland, Duncan J. ^[1]

Texas A & M Univ., College Station, TX (United States)
California Polytechnic State Univ. (CalPoly), San Luis Obispo, CA (United States)
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Polyurethane shape memory polymers (SMPs) with tunable thermomechanical properties and advanced processing capabilities are synthesized, characterized, and implemented in the design of a microactuator medical device prototype. The ability to manipulate glass transition temperature (T_g) and crosslink density in low-molecular weight aliphatic thermoplastic polyurethane SMPs is demonstrated using a synthetic approach that employs UV catalyzed thiol-ene “click” reactions to achieve postpolymerization crosslinking. Polyurethanes containing varying C=C functionalization are synthesized, solution blended with polythiol crosslinking agents and photoinitiator and subjected to UV irradiation, and the effects of number of synthetic parameters on crosslink density are reported. Thermomechanical properties are highly tunable, including glass transitions tailorable between 30 and 105 °C and rubbery moduli tailorable between 0.4 and 20 MPa. This new SMP system exhibits high toughness for many formulations, especially in the case of low crosslink density materials, for which toughness exceeds 90 MJ m^–3 at select straining temperatures. To demonstrate the advanced processing capability and synthetic versatility of this new SMP system, a laser-actuated SMP microgripper device for minimally invasive delivery of endovascular devices is fabricated, shown to exhibit an average gripping force of 1.43 ± 0.37 N and successfully deployed in an in vitro experimental setup under simulated physiological conditions.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); National Science Foundation (NSF); National Institutes of Health (NIH)

Grant/Contract Number:: AC52-07NA27344; 1114211; 2011113646; CHE-1057441; R01EB000462

OSTI ID:: 1828129

Report Number(s):: LLNL-JRNL-828368; 1043766

Journal Information:: Advanced Healthcare Materials, Vol. 4, Issue 9; ISSN 2192-2640

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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4D Printing of Shape Memory-Based Personalized Endoluminal Medical Devices Zarek, Matt; Mansour, Nicola; Shapira, Shir Macromolecular Rapid Communications, Vol. 38, Issue 2 https://doi.org/10.1002/marc.201600628	journal	December 2016
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shape memory polymer
thiol-ene “click” chemistry
structure-property relationships
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