Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

Pezzoli, Stefania; Sánchez-Valle, Raquel; Solanes, Aleix; Kempton, Matthew J.; Bandmann, Oliver; Shin, Jae Il; Cagnin, Annachiara; Goldman, Jennifer G.; Merkitch, Doug; Firbank, Michael J.; Taylor, John-Paul; Pagonabarraga, Javier; Kulisevsky, Jaime; Blanc, Frederic; Verdolini, Norma; Venneri, Annalena; Radua, Joaquim

doi:10.1016/j.neubiorev.2021.06.030

Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

Journal Article · Tue Jun 22 00:00:00 EDT 2021 · Neuroscience and Biobehavioral Reviews

DOI:https://doi.org/10.1016/j.neubiorev.2021.06.030· OSTI ID:1827998

Pezzoli, Stefania ^[1]; Sánchez-Valle, Raquel ^[2]; Solanes, Aleix ^[3]; Kempton, Matthew J. ^[4]; Bandmann, Oliver ^[5]; Shin, Jae Il ^[6]; Cagnin, Annachiara ^[7]; ^[8]; ^[9]; ^[10]; Taylor, John-Paul ^[10]; Pagonabarraga, Javier ^[11]; Kulisevsky, Jaime ^[11]; Blanc, Frederic ^[12]; ^[3]; Venneri, Annalena ^[13]; ^[14]

Univ. of Sheffield (United Kingdom); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Univ. of California, Berkeley, CA (United States)
Univ. of Barcelona (Spain)
Univ. of Barcelona (Spain); Mental Health Research Networking Center (CIBERSAM), Madrid (Spain)
King's College, London (United Kingdom)
Univ. of Sheffield (United Kingdom)
Yonsei Univ. College of Medicine, Seoul (South Korea)
Univ. of Padua (Italy)
Shirley Ryan Ability Lab Parkinson’s Disease and Movement Disorders program, Chicago, IL (United States); Northwestern University Feinberg School of Medicine, Chicago, IL (United States)
Shirley Ryan Ability Lab Parkinson’s Disease and Movement Disorders program, Chicago, IL (United States)
Newcastle Univ. (United Kingdom)
Sant Pau Hospital, Barcelona (Spain); Univ. Autònoma de Barcelona (U.A.B.) (Spain); Inst. d'Investigacions Biomèdiques - Sant Pau (IIB-Sant Pau), Barcelona (Spain); Biomedical Research Networking Center on Neurodegenerative Diseases (CIBERNED), Madrid (Spain)
Newcastle Univ. (United Kingdom); Univ. Hospital of Strasbourg (France)
Univ. of Sheffield (United Kingdom); Brunel Univ., London (United Kingdom)
Univ. of Barcelona (Spain); Mental Health Research Networking Center (CIBERSAM), Madrid (Spain); King's College, London (United Kingdom); Karolinska Inst., Stockholm (Sweden)

Visual hallucinations (VH) are common in Parkinson's disease and dementia with Lewy bodies, two forms of Lewy body disease (LBD), but the neural substrates and mechanisms involved are still unclear. We conducted meta-analyses of voxel-based morphometry (VBM) and neuropsychological studies investigating the neuroanatomical and cognitive correlates of VH in LBD. For VBM (12 studies), we used Seed-based d Mapping with Permutation of Subject Images (SDM-PSI), including statistical parametric maps for 50% of the studies. For neuropsychology (35 studies), we used MetaNSUE to consider non-statistically significant unreported effects. VH were associated with smaller grey matter volume in occipital, frontal, occipitotemporal, and parietal areas (peak Hedges' g -0.34 to -0.49). In patients with Parkinson's disease without dementia, VH were associated with lower verbal immediate memory performance (Hedges' g -0.52). Both results survived correction for multiple comparisons. Here, abnormalities in these brain regions might reflect dysfunctions in brain networks sustaining visuoperceptive, attention, and executive abilities, with the latter also being at the basis of poor immediate memory performance.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1827998

Journal Information:: Neuroscience and Biobehavioral Reviews, Journal Name: Neuroscience and Biobehavioral Reviews Vol. 128; ISSN 0149-7634

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Dementia with Lewy bodies
Grey matter volume
Lewy body disease
MRI
Memory
Meta-analysis
Neuropsychology
Parkinson’s disease
VBM
Visual hallucinations

Neuroanatomical and cognitive correlates of visual hallucinations in Parkinson’s disease and dementia with Lewy bodies: Voxel-based morphometry and neuropsychological meta-analysis

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References (118)

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