NIH Conference. Brain imaging: aging and dementia

Journal Article · Sat Sep 01 04:00:00 EDT 1984 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-101-3-355· OSTI ID:6480621

Cutler, N R; Duara, R; Creasey, H; Grady, C L; Haxby, J V; Schapiro, M B; Rapoport, S I

The brain imaging techniques of positron emission tomography using (18F)-fluoro-2-deoxy-D-glucose, and computed tomography, together with neuropsychological tests, were used to examine overall brain function and anatomy in three study populations: healthy men at different ages, patients with presumptive Alzheimer's disease, and adults with Down's syndrome. Brain glucose use did not differ with age, whereas an age-related decrement in gray matter volume was found on computed tomographic assessment in healthy subjects. Memory deficits were found to precede significant reductions in brain glucose utilization in mild to moderate Alzheimer's dementia. Furthermore, differences between language and visuoconstructive impairments in patients with mild to moderate Alzheimer's disease were related to hemispheric asymmetry of brain metabolism. Brain glucose utilization was found to be significantly elevated in young adults with Down's syndrome, compared with controls. The importance of establishing strict criteria for selecting control subjects and patients is explained in relation to the findings.

• Research Organization: National Institute on Aging, Bethesda, MD
• OSTI ID: 6480621
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 101:3; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE DEPENDENCE
AGE GROUPS
ALDEHYDES
ANIMALS
BEHAVIOR
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELDERLY PEOPLE
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
HUMAN POPULATIONS
ISOTOPES
LIGHT NUCLEI
MALES
MAMMALS
MAN
MEN
MINORITY GROUPS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATIENTS
POPULATIONS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES