Hybrid gels via bulk interfacial complexation of supramolecular polymers and polyelectrolytes

Cotey, Thomas J.; Sai, Hiroaki; Perez, Cynthia; Palmer, Liam C.; Stupp, Samuel I.

doi:10.1039/d1sm00168j

Hybrid gels via bulk interfacial complexation of supramolecular polymers and polyelectrolytes

Journal Article · Wed Mar 31 00:00:00 EDT 2021 · Soft Matter

DOI:https://doi.org/10.1039/d1sm00168j· OSTI ID:1823105

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Northwestern Univ., Evanston, IL (United States); CBES
Northwestern Univ., Evanston, IL (United States); Northwestern Univ., Chicago, IL (United States)
Northwestern Univ., Evanston, IL (United States)

Hierarchical self-assembly leading to organized supramolecular structures across multiple length scales has been of great recent interest. Earlier work from our laboratory reported the complexation of peptide amphiphile (PA) supramolecular polymers with oppositely charged polyelectrolytes into a single solid membrane at a macroscopic interface. We report here the formation of bulk gels with many internal interfaces between the covalent and supramolecular polymer components formed by the rapid chaotic mixing of solutions, one containing negatively charged PA nanofibers and the other the positively charged biopolymer chitosan. We found that formation of a contact layer at the interface of the solutions locks the formation of hydrogels with lamellar microstructure. The nanofiber morphology of the supramolecular polymer is essential to this process since gels do not form when solutions of supramolecular assemblies form spherical micelles. Here, we found that rheological properties of the gels can be tuned by changing the relative amounts of each component. Furthermore, both positively and negatively charged proteins are easily encapsulated within the contact layer of the gel, which provides an interesting biomedical function for these systems.

View Accepted Manuscript (DOE)

Research Organization:: Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357; SC0000989

OSTI ID:: 1823105

Alternate ID(s):: OSTI ID: 1814977
OSTI ID: 1818331
OSTI ID: 1846602
OSTI ID: 1773523

Journal Information:: Soft Matter, Journal Name: Soft Matter Journal Issue: 19 Vol. 17; ISSN 1744-683X

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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