Energy landscapes and functions of supramolecular systems

Tantakitti, Faifan; Boekhoven, Job; Wang, Xin; Kazantsev, Roman V.; Yu, Tao; Li, Jiahe; Zhuang, Ellen; Zandi, Roya; Ortony, Julia H.; Newcomb, Christina J.; Palmer, Liam C.; Shekhawat, Gajendra S.; de la Cruz, Monica Olvera; Schatz, George C.; Stupp, Samuel I.

doi:10.1038/nmat4538

Energy landscapes and functions of supramolecular systems

Journal Article · Mon Jan 18 00:00:00 EST 2016 · Nature Materials

DOI:https://doi.org/10.1038/nmat4538· OSTI ID:1820613

Tantakitti, Faifan ^[1]; Boekhoven, Job ^[2]; Wang, Xin ^[3]; Kazantsev, Roman V. ^[3]; Yu, Tao ^[3]; Li, Jiahe ^[4]; Zhuang, Ellen ^[3]; Zandi, Roya ^[3]; Ortony, Julia H. ^[5]; Newcomb, Christina J. ^[6]; ^[5]; Shekhawat, Gajendra S. ^[3]; de la Cruz, Monica Olvera ^[7]; Schatz, George C. ^[8]; Stupp, Samuel I. ^[9]

Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States); Northwestern CBES
Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States); Technische Univ. München, Munich (Germany); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Northwestern Univ., Evanston, IL (United States)
Dept. of Chemical and Biological Engineering, Evanston, IL (United States)
Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States)
Northwestern Univ., Chicago, IL (United States); Technische Univ. München, Munich (Germany); Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Northwestern Univ., Evanston, IL (United States); Dept. of Chemical and Biological Engineering, Evanston, IL (United States); Dept. of Physics & Astronomy, Evanston, IL (United States)
Northwestern Univ., Evanston, IL (United States); Dept. of Chemical and Biological Engineering, Evanston, IL (United States)
Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States); Dept. of Biomedical Engineering, Evanston, IL (United States)

By means of two supramolecular systems—peptide amphiphiles engaged in hydrogen-bonded β-sheets, and chromophore amphiphiles driven to assemble by π-orbital overlaps—we show that the minima in the energy landscapes of supramolecular systems are defined by electrostatic repulsion and the ability of the dominant attractive forces to trap molecules in thermodynamically unfavourable configurations. Furthermore, these competing interactions can be selectively switched on and off, with the order of doing so determining the position of the final product in the energy landscape. Within the same energy landscape, the peptide-amphiphile system forms a thermodynamically favoured product characterized by long bundled fibres that promote biological cell adhesion and survival, and a metastable product characterized by short monodisperse fibres that interfere with adhesion and can lead to cell death. Our findings suggest that, in supramolecular systems, functions and energy landscapes are linked, superseding the more traditional connection between molecular design and function.

View Accepted Manuscript (DOE)

Research Organization:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0000989

OSTI ID:: 1820613

Alternate ID(s):: OSTI ID: 1387388

Journal Information:: Nature Materials, Journal Name: Nature Materials Journal Issue: 4 Vol. 15; ISSN 1476-1122

Publisher:: Springer Nature - Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures

Journal Article · Tue Jul 13 20:00:00 EDT 2021 · Nano Letters · OSTI ID:1846599

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