Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures

Sangji, M. Hussain; Sai, Hiroaki; Chin, Stacey M.; Lee, Sieun Ruth; Sasselli, Ivan R.; Palmer, Liam C.; Stupp, Samuel I.

doi:10.1021/acs.nanolett.1c01737

Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures

Journal Article · Wed Jul 14 04:00:00 EDT 2021 · Nano Letters

DOI:https://doi.org/10.1021/acs.nanolett.1c01737· OSTI ID:1846599

^[1]; ^[2]; ^[3]; Lee, Sieun Ruth ^[4]; ^[5]; ^[6]; ^[7]

Northwestern Univ., Evanston, IL (United States); Center for Bio-Inspired Energy Science
Northwestern Univ., Chicago, IL (United States); Northwestern Univ., Evanston, IL (United States)
Northwestern Univ., Evanston, IL (United States)
Department of Materials Science and Engineering, Evanston, IL (United States)
Northwestern Univ., Evanston, IL (United States); Northwestern Univ., Chicago, IL (United States); Basque Research and Technology Alliance (BRTA), San Sebastian (Spain)
Northwestern Univ., Evanston, IL (United States); Northwestern Univ., Chicago, IL (United States)
Northwestern Univ., Evanston, IL (United States); Department of Materials Science and Engineering, Evanston, IL (United States); Northwestern Univ., Chicago, IL (United States)

The morphology of supramolecular peptide nanostructures is difficult to predict given their complex energy landscapes. We investigated peptide amphiphiles containing β-sheet forming domains that form twisted nanoribbons in water. We explained the morphology based on a balance between the energetically favorable packing of molecules in the center of the nanostructures, the unfavorable packing at the edges, and the deformations due to packing of twisted β-sheets. We find that morphological polydispersity of PA nanostructures is determined by peptide sequences, and the twisting of their internal β-sheets. Here, we also observed a change in the supramolecular chirality of the nanostructures as the peptide sequence was modified, although only amino acids with l-configuration were used. Upon increasing charge repulsion between molecules, we observed a change in morphology to long cylinders and then rodlike fragments and spherical micelles. Understanding the self-assembly mechanisms of peptide amphiphiles into nanostructures should be useful to optimize their well-known functions.

View Accepted Manuscript (DOE)

Research Organization:: Northwestern Univ., Evanston, IL (United States). Center for Bio-Inspired Energy Science

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0000989

OSTI ID:: 1846599

Alternate ID(s):: OSTI ID: 1819320
OSTI ID: 1820460
OSTI ID: 1866094

Journal Information:: Nano Letters, Journal Name: Nano Letters Journal Issue: 14 Vol. 21; ISSN 1530-6984

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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