Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Rush, Tomás A.; Shrestha, Him K.; Gopalakrishnan Meena, Muralikrishnan; Spangler, Margaret K.; Ellis, J. Christopher; Labbé, Jesse L.; Abraham, Paul E.

doi:10.3389/ffunb.2021.716511

Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Journal Article · Thu Sep 16 00:00:00 EDT 2021 · Frontiers in Fungal Biology

DOI:https://doi.org/10.3389/ffunb.2021.716511· OSTI ID:1820513

Rush, Tomás A.; Shrestha, Him K.; Gopalakrishnan Meena, Muralikrishnan; Spangler, Margaret K.; Ellis, J. Christopher; Labbé, Jesse L.; Abraham, Paul E.

Natural products derived from microbes are crucial innovations that would help in reaching sustainability development goals worldwide while achieving bioeconomic growth. Trichoderma species are well-studied model fungal organisms used for their biocontrol properties with great potential to alleviate the use of agrochemicals in agriculture. However, identifying and characterizing effective natural products in novel species or strains as biological control products remains a meticulous process with many known challenges to be navigated. Integration of recent advancements in various “omics” technologies, next generation biodesign, machine learning, and artificial intelligence approaches could greatly advance bioprospecting goals. Herein, we propose a roadmap for assessing the potential impact of already known or newly discovered Trichoderma species for biocontrol applications. By screening publicly available Trichoderma genome sequences, we first highlight the prevalence of putative biosynthetic gene clusters and antimicrobial peptides among genomes as an initial step toward predicting which organisms could increase the diversity of natural products. Next, we discuss high-throughput methods for screening organisms to discover and characterize natural products and how these findings impact both fundamental and applied research fields.

View Journal Article

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1820513

Alternate ID(s):: OSTI ID: 1823350

Journal Information:: Frontiers in Fungal Biology, Journal Name: Frontiers in Fungal Biology Vol. 2; ISSN 2673-6128

Publisher:: Frontiers Media SACopyright Statement

Country of Publication:: Switzerland

Language:: English

References (291)

Targeted Metabolomics Roberts, Lee D.; Souza, Amanda L.; Gerszten, Robert E. Current Protocols in Molecular Biology, Vol. 98, Issue 1 https://doi.org/10.1002/0471142727.mb3002s98	journal	April 2012
Machine learning: A powerful tool for gene function prediction in plants Mahood, Elizabeth H.; Kruse, Lars H.; Moghe, Gaurav D. Applications in Plant Sciences, Vol. 8, Issue 7 https://doi.org/10.1002/aps3.11376	journal	July 2020
The crystal and molecular structure of the ?-helical nonapeptide antibiotic leucinostatin A Cerrini, S.; Lamba, D.; Scatturin, A. Biopolymers, Vol. 28, Issue 1 https://doi.org/10.1002/bip.360280138	journal	January 1989
Recent Advances and Future Prospects in Peptaibiotics, Hydrophobin, and Mycotoxin Research, and Their Importance for Chemotaxonomy ofTrichoderma andHypocrea Degenkolb, Thomas; von Döhren, Hans; Fog Nielsen, Kristian Chemistry & Biodiversity, Vol. 5, Issue 5 https://doi.org/10.1002/cbdv.200890064	journal	May 2008
The Comprehensive Peptaibiotics Database Stoppacher, Norbert; Neumann, Nora K. N.; Burgstaller, Lukas Chemistry & Biodiversity, Vol. 10, Issue 5 https://doi.org/10.1002/cbdv.201200427	journal	May 2013
The Peptaibiotics Database - A Comprehensive Online Resource Neumann, Nora K. N.; Stoppacher, Norbert; Zeilinger, Susanne Chemistry & Biodiversity, Vol. 12, Issue 5 https://doi.org/10.1002/cbdv.201400393	journal	May 2015
Pyriculins A and B, two monosubstituted hex-4-ene-2,3-diols and other phytotoxic metabolites produced by Pyricularia grisea isolated from buffelgrass ( Cenchrus ciliaris ) Masi, Marco; Meyer, Susan; Górecki, Marcin Chirality, Vol. 29, Issue 11 https://doi.org/10.1002/chir.22744	journal	September 2017
Isolierung und Abbau von Sordarin. 1. Mitteilung über Sordarin Hauser, D.; Sigg, H. P. Helvetica Chimica Acta, Vol. 54, Issue 4 https://doi.org/10.1002/hlca.19710540427	journal	April 1971
Identifying secreted proteins of Marssonina brunnea by degenerate PCR Cheng, Qiang; Cao, Youzhi; Jiang, Cong PROTEOMICS, Vol. 10, Issue 13 https://doi.org/10.1002/pmic.200900844	journal	April 2010
PEAKS: powerful software for peptidede novo sequencing by tandem mass spectrometry Ma, Bin; Zhang, Kaizhong; Hendrie, Christopher Rapid Communications in Mass Spectrometry, Vol. 17, Issue 20 https://doi.org/10.1002/rcm.1196	journal	January 2003
Biological Control as a Tool for Ecosystem Management Headrick, David H.; Goeden, Richard D. Biological Control, Vol. 21, Issue 3 https://doi.org/10.1006/bcon.2001.0939	journal	July 2001
Transformation of Trichoderma harzianum by high-voltage electric pulse Goldman, G. H.; Van Montagu, M.; Herrera-Estrella, A. Current Genetics, Vol. 17, Issue 2, p. 169-174 https://doi.org/10.1007/BF00312863	journal	February 1990
The development of a heterologous transformation system for the cellulolytic fungus Trichoderma reesei based on a pyrG-negative mutant strain Gruber, F.; Visser, J.; Kubicek, C. P. Current Genetics, Vol. 18, Issue 1 https://doi.org/10.1007/BF00321118	journal	July 1990
N ? -Dimethylcoprogens Three novel trihydroxamate siderophores from pathogenic fungi Jalal, Mahbubul A. F.; Love, Steve K.; Helm, Dick Biology of Metals, Vol. 1, Issue 1 https://doi.org/10.1007/BF01128011	journal	January 1988
Natural occurrence of citrinin in rice grains and its biocontrol byTrichoderma hamatum Abd-Allah, E. F.; Ezzat, S. M. Phytoparasitica, Vol. 33, Issue 1 https://doi.org/10.1007/BF02980928	journal	March 2005
Development of a transformation system forTrichoderma longibrachiatum and its use for constructing multicopy transformants for theegl1 gene Sánchez-Torres, P.; González, R.; Pérez-González, J. A. Applied Microbiology and Biotechnology, Vol. 41, Issue 4 https://doi.org/10.1007/bf01982533	journal	June 1994
Hybridization in Endophyte Symbionts Alters Host Response to Moisture and Nutrient Treatments Hamilton, Cyd E.; Dowling, Thomas E.; Faeth, Stanley H. Microbial Ecology, Vol. 59, Issue 4 https://doi.org/10.1007/s00248-009-9606-9	journal	November 2009
Effects of Hybrid and Non-hybrid Epichloë Endophytes and Their Associated Host Genotypes on the Response of a Native Grass to Varying Environments Jia, Tong; Oberhofer, Martina; Shymanovich, Tatsiana Microbial Ecology, Vol. 72, Issue 1 https://doi.org/10.1007/s00248-016-0743-7	journal	February 2016
Agrobacterium-mediated transformation (AMT) of Trichoderma reesei as an efficient tool for random insertional mutagenesis Zhong, Yao Hua; Wang, Xiao Li; Wang, Tian Hong Applied Microbiology and Biotechnology, Vol. 73, Issue 6 https://doi.org/10.1007/s00253-006-0603-3	journal	January 2007
Biology and biotechnology of Trichoderma Schuster, André; Schmoll, Monika Applied Microbiology and Biotechnology, Vol. 87, Issue 3 https://doi.org/10.1007/s00253-010-2632-1	journal	May 2010
Unraveling the efficient applications of secondary metabolites of various Trichoderma spp. Keswani, Chetan; Mishra, Sandhya; Sarma, Birinchi Kumar Applied Microbiology and Biotechnology, Vol. 98, Issue 2 https://doi.org/10.1007/s00253-013-5344-5	journal	November 2013
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi Tran, Phuong Nguyen; Yen, Ming-Ren; Chiang, Chen-Yu Applied Microbiology and Biotechnology, Vol. 103, Issue 8 https://doi.org/10.1007/s00253-019-09708-z	journal	March 2019
Antimicrobial secondary metabolites from agriculturally important fungi as next biocontrol agents Keswani, Chetan; Singh, Harikesh B.; Hermosa, Rosa Applied Microbiology and Biotechnology, Vol. 103, Issue 23-24 https://doi.org/10.1007/s00253-019-10209-2	journal	November 2019
Gene disruption in Trichoderma atroviride via Agrobacterium -mediated transformation Zeilinger, Susanne Current Genetics, Vol. 45, Issue 1 https://doi.org/10.1007/s00294-003-0454-8	journal	February 2004
Identification of a hybrid PKS–NRPS required for the biosynthesis of NG-391 in Metarhizium robertsii Donzelli, Bruno Giuliano Garisto; Krasnoff, Stuart B.; Churchill, Alice C. L. Current Genetics, Vol. 56, Issue 2 https://doi.org/10.1007/s00294-010-0288-0	journal	February 2010
Trichoderma viride Tv-1511 Colonizes Arabidopsis Leaves and Promotes Arabidopsis Growth by Modulating the MAP Kinase 6-Mediated Activation of Plasma Membrane H+-ATPase Guo, Kai; Sui, Yonghui; Li, Zhe Journal of Plant Growth Regulation, Vol. 39, Issue 3 https://doi.org/10.1007/s00344-019-10063-6	journal	January 2020
Biological control using invertebrates and microorganisms: plenty of new opportunities van Lenteren, Joop C.; Bolckmans, Karel; Köhl, Jürgen BioControl, Vol. 63, Issue 1 https://doi.org/10.1007/s10526-017-9801-4	journal	March 2017
The status of biological control and recommendations for improving uptake for the future Barratt, B. I. P.; Moran, V. C.; Bigler, F. BioControl, Vol. 63, Issue 1 https://doi.org/10.1007/s10526-017-9831-y	journal	July 2017
6-Pentyl-2H-pyran-2-one: A Potent Peach-Derived Kairomone for New Zealand Flower Thrips, Thrips obscuratus El-Sayed, A. M.; Mitchell, V. J.; Suckling, D. M. Journal of Chemical Ecology, Vol. 40, Issue 1 https://doi.org/10.1007/s10886-014-0379-3	journal	January 2014
Trichoderma harzianum: a biocontrol agent against Bipolaris oryzae Abdel-Fattah, Gamal M.; Shabana, Yasser M.; Ismail, Adel E. Mycopathologia, Vol. 164, Issue 2 https://doi.org/10.1007/s11046-007-9032-9	journal	June 2007
Secondary metabolites from species of the biocontrol agent Trichoderma Reino, José Luis; Guerrero, Raul F.; Hernández-Galán, Rosario Phytochemistry Reviews, Vol. 7, Issue 1 https://doi.org/10.1007/s11101-006-9032-2	journal	March 2007
Functional genomic analysis of Arabidopsis thaliana glycoside hydrolase family 1 Xu, Zhiwei; Escamilla-Trevi�o, Luis; Zeng, Lihui Plant Molecular Biology, Vol. 55, Issue 3 https://doi.org/10.1007/s11103-004-0790-1	journal	May 2004
The Trichoderma brevicompactum clade: a separate lineage with new species, new peptaibiotics, and mycotoxins Degenkolb, Thomas; Dieckmann, Ralf; Nielsen, Kristian Fog Mycological Progress, Vol. 7, Issue 3 https://doi.org/10.1007/s11557-008-0563-3	journal	July 2008
Agrobacterium tumefaciens Mediated Transformation of ChiV Gene to Trichoderma harzianum Yang, Liming; Yang, Qian; Sun, Kening Applied Biochemistry and Biotechnology, Vol. 163, Issue 8 https://doi.org/10.1007/s12010-010-9097-7	journal	October 2010
The rising threat of fungicide resistance in plant pathogenic fungi: Botrytis as a case study Hahn, Matthias Journal of Chemical Biology, Vol. 7, Issue 4 https://doi.org/10.1007/s12154-014-0113-1	journal	May 2014
Soil beneficial bacteria and their role in plant growth promotion: a review Hayat, Rifat; Ali, Safdar; Amara, Ummay Annals of Microbiology, Vol. 60, Issue 4 https://doi.org/10.1007/s13213-010-0117-1	journal	August 2010
Fungicolous fungi: terminology, diversity, distribution, evolution, and species checklist Sun, Jing-Zu; Liu, Xing-Zhong; McKenzie, Eric H. C. Fungal Diversity, Vol. 95, Issue 1 https://doi.org/10.1007/s13225-019-00422-9	journal	March 2019
In honor of John Bissett: authoritative guidelines on molecular identification of Trichoderma Cai, Feng; Druzhinina, Irina S. Fungal Diversity, Vol. 107, Issue 1 https://doi.org/10.1007/s13225-020-00464-4	journal	February 2021
Untargeted Metabolomics Strategies—Challenges and Emerging Directions Schrimpe-Rutledge, Alexandra C.; Codreanu, Simona G.; Sherrod, Stacy D. Journal of The American Society for Mass Spectrometry, Vol. 27, Issue 12 https://doi.org/10.1007/s13361-016-1469-y	journal	September 2016
An efficient transformation system for Trichoderma atroviride using the pyr4 gene as a selectable marker Calcáneo-Hernández, Gabriela; Rojas-Espinosa, Erick; Landeros-Jaime, Fidel Brazilian Journal of Microbiology, Vol. 51, Issue 4 https://doi.org/10.1007/s42770-020-00329-7	journal	July 2020
Curvupallides, a new class of alkaloids from the fungus Curvularia pallescens Abraham, Wolf-Rainer; Meyer, Holger; Abate, Dawit Tetrahedron, Vol. 51, Issue 17 https://doi.org/10.1016/0040-4020(95)98692-B	journal	April 1995
Ion channel-forming property of trichorovin-XII, an 11-residue peptaibol from the fungus Trichoderma viride, in planar lipid bilayer membranes Wada, Shun-ichi; Iida, Akira; Asami, Koji Bioorganic & Medicinal Chemistry Letters, Vol. 6, Issue 19 https://doi.org/10.1016/0960-894X(96)00410-6	journal	October 1996
The destruxins: synthesis, biosynthesis, biotransformation, and biological activity Pedras, M. Soledade C.; Irina Zaharia, L.; Ward, Dale E. Phytochemistry, Vol. 59, Issue 6 https://doi.org/10.1016/S0031-9422(02)00016-X	journal	March 2002
Neosartorin, an ergochrome biosynthesized by Neosartorya fischeri Proksa, B.; Uhrín, D.; Liptaj, T. Phytochemistry, Vol. 48, Issue 7 https://doi.org/10.1016/S0031-9422(98)00169-1	journal	August 1998
Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase Singh, Sheo B.; Zink, Deborah L.; Goetz, Michael A. Tetrahedron Letters, Vol. 39, Issue 16 https://doi.org/10.1016/S0040-4039(98)00269-X	journal	April 1998
Biolistic transformation of Trichoderma reesei using the Bio-Rad seven barrels Hepta Adaptor system Te'o, V. S. J.; Bergquist, P. L.; Nevalainen, K. M. H. Journal of Microbiological Methods, Vol. 51, Issue 3 https://doi.org/10.1016/S0167-7012(02)00126-4	journal	November 2002
A method for high-frequency transformation of Trichoderma viride Manczinger, László; Komonyi, Orbán; Antal, Zsuzsanna Journal of Microbiological Methods, Vol. 29, Issue 3 https://doi.org/10.1016/S0167-7012(97)00026-2	journal	June 1997
Biocontrol efficacy of Trichoderma isolates for tan spot of wheat in Argentina Perelló, A.; Mónaco, C.; Simón, M. R. Crop Protection, Vol. 22, Issue 9 https://doi.org/10.1016/S0261-2194(03)00143-1	journal	November 2003
Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes Bills, Gerald F.; Peláez, Fernando; Polishook, Jon D. Mycological Research, Vol. 98, Issue 7 https://doi.org/10.1016/S0953-7562(09)81046-0	journal	July 1994
Biocontrol potential of a native species of Trichoderma longibrachiatum against Meloidogyne incognita Zhang, Shuwu; Gan, Yantai; Xu, Bingliang Applied Soil Ecology, Vol. 94 https://doi.org/10.1016/j.apsoil.2015.04.010	journal	October 2015
Ascochlorin is a novel, specific inhibitor of the mitochondrial cytochrome bc1 complex Berry, Edward A.; Huang, Li-shar; Lee, Dong-Woo Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1797, Issue 3 https://doi.org/10.1016/j.bbabio.2009.12.003	journal	March 2010
Ferricrocin, the intracellular siderophore of Trichoderma virens, is involved in growth, conidiation, gliotoxin biosynthesis and induction of systemic resistance in maize Mukherjee, Prasun K.; Hurley, James F.; Taylor, James T. Biochemical and Biophysical Research Communications, Vol. 505, Issue 2 https://doi.org/10.1016/j.bbrc.2018.09.170	journal	October 2018
Antagonistic fungi, Trichoderma spp.: Panoply of biological control Verma, Mausam; Brar, Satinder K.; Tyagi, R. D. Biochemical Engineering Journal, Vol. 37, Issue 1 https://doi.org/10.1016/j.bej.2007.05.012	journal	October 2007
Mechanisms underlying the protective effects of beneficial fungi against plant diseases Ghorbanpour, Mansour; Omidvari, Mahtab; Abbaszadeh-Dahaji, Payman Biological Control, Vol. 117 https://doi.org/10.1016/j.biocontrol.2017.11.006	journal	February 2018
Natural products in crop protection Dayan, Franck E.; Cantrell, Charles L.; Duke, Stephen O. Bioorganic & Medicinal Chemistry, Vol. 17, Issue 12 https://doi.org/10.1016/j.bmc.2009.01.046	journal	June 2009
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids Bokesch, Heidi R.; Cartner, Laura K.; Fuller, Richard W. Bioorganic & Medicinal Chemistry Letters, Vol. 20, Issue 13 https://doi.org/10.1016/j.bmcl.2010.05.057	journal	July 2010
Glycoside hydrolase (PelAh) immobilization prevents Pseudomonas aeruginosa biofilm formation on cellulose-based wound dressing Szymańska, Magdalena; Karakulska, Jolanta; Sobolewski, Peter Carbohydrate Polymers, Vol. 246 https://doi.org/10.1016/j.carbpol.2020.116625	journal	October 2020
Natural product discovery through microbial genome mining Kenshole, Emma; Herisse, Marion; Michael, Michael Current Opinion in Chemical Biology, Vol. 60 https://doi.org/10.1016/j.cbpa.2020.07.010	journal	February 2021
Genetic Manipulation of the Fusarium fujikuroi Fusarin Gene Cluster Yields Insight into the Complex Regulation and Fusarin Biosynthetic Pathway Niehaus, Eva-Maria; Kleigrewe, Karin; Wiemann, Philipp Chemistry & Biology, Vol. 20, Issue 8 https://doi.org/10.1016/j.chembiol.2013.07.004	journal	August 2013
Biological control by Trichoderma species of Fusarium solani causing peanut brown root rot under field conditions Rojo, Federico G.; Reynoso, Maria M.; Ferez, Marcela Crop Protection, Vol. 26, Issue 4 https://doi.org/10.1016/j.cropro.2006.05.006	journal	April 2007
Horizontal Transfer of a Large and Highly Toxic Secondary Metabolic Gene Cluster between Fungi Slot, Jason C.; Rokas, Antonis Current Biology, Vol. 21, Issue 2 https://doi.org/10.1016/j.cub.2010.12.020	journal	January 2011
Update on the environmental and economic costs associated with alien-invasive species in the United States Pimentel, David; Zuniga, Rodolfo; Morrison, Doug Ecological Economics, Vol. 52, Issue 3 https://doi.org/10.1016/j.ecolecon.2004.10.002	journal	February 2005
Secondary metabolism in Trichoderma – Chemistry meets genomics Zeilinger, Susanne; Gruber, Sabine; Bansal, Ravindra Fungal Biology Reviews, Vol. 30, Issue 2 https://doi.org/10.1016/j.fbr.2016.05.001	journal	June 2016
Molecular dialogues between Trichoderma and roots: Role of the fungal secretome Mendoza-Mendoza, Artemio; Zaid, Rinat; Lawry, Robert Fungal Biology Reviews, Vol. 32, Issue 2 https://doi.org/10.1016/j.fbr.2017.12.001	journal	March 2018
Overexpression of the trichodiene synthase gene tri5 increases trichodermin production and antimicrobial activity in Trichoderma brevicompactum Tijerino, Anamariela; Elena Cardoza, R.; Moraga, Javier Fungal Genetics and Biology, Vol. 48, Issue 3 https://doi.org/10.1016/j.fgb.2010.11.012	journal	March 2011
Monitoring indole alkaloid production by Penicillium digitatum during infection process in citrus by Mass Spectrometry Imaging and molecular networking Costa, Jonas Henrique; Bazioli, Jaqueline Moraes; de Vilhena Araújo, Eder Fungal Biology, Vol. 123, Issue 8 https://doi.org/10.1016/j.funbio.2019.03.002	journal	August 2019
Cloning and molecular characterization of the gene encoding the Aureobasidin A biosynthesis complex in Aureobasidium pullulans BP-1938 Slightom, Jerry L.; Metzger, Brian P.; Luu, Hang T. Gene, Vol. 431, Issue 1-2 https://doi.org/10.1016/j.gene.2008.11.011	journal	February 2009
Interspecific hybridization impacts host range and pathogenicity of filamentous microbes Depotter, Jasper RL; Seidl, Michael F.; Wood, Thomas A. Current Opinion in Microbiology, Vol. 32 https://doi.org/10.1016/j.mib.2016.04.005	journal	August 2016
Quantitative isolation of biocontrol agents Trichoderma spp., Gliocladium spp. and actinomycetes from soil with culture media Vargas Gil, S.; Pastor, S.; March, G. J. Microbiological Research, Vol. 164, Issue 2 https://doi.org/10.1016/j.micres.2006.11.022	journal	January 2009
Novel Trichoderma strains isolated from tree barks as potential biocontrol agents and biofertilizers for direct seeded rice Swain, Harekrushna; Adak, Totan; Mukherjee, Arup K. Microbiological Research, Vol. 214 https://doi.org/10.1016/j.micres.2018.05.015	journal	September 2018
A socioeconomic analysis of biocontrol in integrated pest management: A review of the effects of uncertainty, irreversibility and flexibility Benjamin, Emmanuel. O.; Wesseler, Justus. H. H. NJAS: Wageningen Journal of Life Sciences, Vol. 77, Issue 1 https://doi.org/10.1016/j.njas.2016.03.002	journal	June 2016
Identification of the antifungal activity of Trichoderma longibrachiatum T6 and assessment of bioactive substances in controlling phytopathgens Zhang, Shuwu; Xu, Bingliang; Zhang, Jianhua Pesticide Biochemistry and Physiology, Vol. 147 https://doi.org/10.1016/j.pestbp.2018.02.006	journal	May 2018
The new koninginins T-U from Phomopsis stipata, an endophytic fungus isolated from Styrax camporum Pohl Biasetto, Carolina R.; Somensi, Andressa; Sordi, Renata Phytochemistry Letters, Vol. 36 https://doi.org/10.1016/j.phytol.2020.01.019	journal	April 2020
A novel role for Trichoderma secondary metabolites in the interactions with plants Vinale, F.; Sivasithamparam, K.; Ghisalberti, E. L. Physiological and Molecular Plant Pathology, Vol. 72, Issue 1-3 https://doi.org/10.1016/j.pmpp.2008.05.005	journal	January 2008
Endophytic fungi isolated from Pelargonium sidoides DC: Antimicrobial interaction and isolation of a bioactive compound Aboobaker, Z.; Viljoen, A.; Chen, W. South African Journal of Botany, Vol. 122 https://doi.org/10.1016/j.sajb.2019.01.011	journal	May 2019
Trichoderma–plant–pathogen interactions Vinale, Francesco; Sivasithamparam, Krishnapillai; Ghisalberti, Emilio L. Soil Biology and Biochemistry, Vol. 40, Issue 1 https://doi.org/10.1016/j.soilbio.2007.07.002	journal	January 2008
Phyllostictines A–D, oxazatricycloalkenones produced by Phyllosticta cirsii, a potential mycoherbicide for Cirsium arvense biocontrol Evidente, Antonio; Cimmino, Alessio; Andolfi, Anna Tetrahedron, Vol. 64, Issue 8 https://doi.org/10.1016/j.tet.2007.12.010	journal	February 2008
Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii Souza, Afonso D. L.; Rodrigues-Filho, Edson; Souza, Antonia Q. L. Toxicon, Vol. 51, Issue 2 https://doi.org/10.1016/j.toxicon.2007.09.009	journal	February 2008
Antifungal effects of the bioactive compounds enniatins A, A1, B, B1 Meca, G.; Soriano, J. M.; Gaspari, A. Toxicon, Vol. 56, Issue 3 https://doi.org/10.1016/j.toxicon.2010.04.013	journal	September 2010
The anatomy of a large-scale hypertextual Web search engine Brin, Sergey; Page, Lawrence Computer Networks and ISDN Systems, Vol. 30, Issue 1-7 https://doi.org/10.1016/s0169-7552(98)00110-x	journal	April 1998
Biocontrol efficacy and other characteristics of protoplast fusants between Trichoderma koningii and T. virens Hanson, Linda E.; Howell, Charles R. Mycological Research, Vol. 106, Issue 3 https://doi.org/10.1017/S0953756202005592	journal	March 2002
The North American mushroom competitor, Trichoderma aggressivum f. aggressivum, produces antifungal compounds in mushroom compost that inhibit mycelial growth of the commercial mushroom Agaricus bisporus Krupke, Oliver Albert; Castle, Alan J.; Rinker, Danny Lee Mycological Research, Vol. 107, Issue 12 https://doi.org/10.1017/S0953756203008621	journal	December 2003
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 Newman, David J.; Cragg, Gordon M. Journal of Natural Products, Vol. 83, Issue 3 https://doi.org/10.1021/acs.jnatprod.9b01285	journal	March 2020
Enantioselective Total Synthesis of (+)-Iso-A82775C, a Proposed Biosynthetic Precursor of Chloropupukeananin Suzuki, Takahiro; Watanabe, Soichiro; Kobayashi, Susumu Organic Letters, Vol. 19, Issue 4 https://doi.org/10.1021/acs.orglett.7b00085	journal	January 2017
Biogenetically-Inspired Total Synthesis of Epidithiodiketopiperazines and Related Alkaloids Kim, Justin; Movassaghi, Mohammad Accounts of Chemical Research, Vol. 48, Issue 4 https://doi.org/10.1021/ar500454v	journal	April 2015
Fungal Indole Alkaloid Biosynthesis: Genetic and Biochemical Investigation of the Tryptoquialanine Pathway in Penicillium aethiopicum Gao, Xue; Chooi, Yit-Heng; Ames, Brian D. Journal of the American Chemical Society, Vol. 133, Issue 8 https://doi.org/10.1021/ja1101085	journal	February 2011
Penicillium digitatum Metabolites on Synthetic Media and Citrus Fruits Ariza, Marta R.; Larsen, Thomas O.; Duus, Jens Ø. Journal of Agricultural and Food Chemistry, Vol. 50, Issue 22 https://doi.org/10.1021/jf020398d	journal	October 2002
Trichothecene Production by Trichoderma brevicompactum Nielsen, Kristian Fog; Gräfenhan, Tom; Zafari, Doustmorad Journal of Agricultural and Food Chemistry, Vol. 53, Issue 21 https://doi.org/10.1021/jf051279b	journal	October 2005
Biological Activity of 6-Pentyl-2 H -pyran-2-one and Its Analogs Parker, Stephen R.; Cutler, Horace G.; Jacyno, John M. Journal of Agricultural and Food Chemistry, Vol. 45, Issue 7 https://doi.org/10.1021/jf960681a	journal	July 1997
Antifungal Spectrum, In Vivo Efficacy, and Structure–Activity Relationship of Ilicicolin H Singh, Sheo B.; Liu, Weiguo; Li, Xiaohua ACS Medicinal Chemistry Letters, Vol. 3, Issue 10 https://doi.org/10.1021/ml300173e	journal	September 2012
Nonribosomal Peptide Synthetases Involved in the Production of Medically Relevant Natural Products Felnagle, Elizabeth A.; Jackson, Emily E.; Chan, Yolande A. Molecular Pharmaceutics, Vol. 5, Issue 2 https://doi.org/10.1021/mp700137g	journal	January 2008
Bioactive Carotanes from Trichoderma v irens Macías, Francisco A.; Varela, Rosa M.; Simonet, Ana M. Journal of Natural Products, Vol. 63, Issue 9 https://doi.org/10.1021/np000121c	journal	September 2000
Cytotoxic Hypothemycin Analogues from Hypomyces subiculosus Wee, Janice L.; Sundermann, Kurt; Licari, Peter Journal of Natural Products, Vol. 69, Issue 10 https://doi.org/10.1021/np060258o	journal	September 2006
Serinocyclins A and B, Cyclic Heptapeptides from Metarhizium anisopliae Krasnoff, Stuart B.; Keresztes, Ivan; Gillilan, Richard E. Journal of Natural Products, Vol. 70, Issue 12 https://doi.org/10.1021/np070407i	journal	November 2007
Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation Kingston, David G. I. Journal of Natural Products, Vol. 74, Issue 3 https://doi.org/10.1021/np100550t	journal	March 2011
Isolation and Structure Elucidation of Fujikurins A–D: Products of the PKS19 Gene Cluster in Fusarium fujikuroi von Bargen, Katharina Walburga; Niehaus, Eva-Maria; Krug, Isabel Journal of Natural Products, Vol. 78, Issue 8 https://doi.org/10.1021/np5008137	journal	July 2015
Clavaric Acid: A Triterpenoid Inhibitor of Farnesyl-Protein Transferase from Clavariadelphus t runcatus Jayasuriya, Hiranthi; Silverman, Keith C.; Zink, Deborah L. Journal of Natural Products, Vol. 61, Issue 12 https://doi.org/10.1021/np980200c	journal	October 1998
Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system Liu, Rui; Chen, Ling; Jiang, Yanping Cell Discovery, Vol. 1, Article No. 15007 https://doi.org/10.1038/celldisc.2015.7	journal	May 2015
Verticillin A is likely not produced by Verticillium sp. Schenke, Dirk; Böttcher, Christoph; Lee, Justin The Journal of Antibiotics, Vol. 64, Issue 7 https://doi.org/10.1038/ja.2011.36	journal	April 2011
Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase Kudo, Fumitaka; Matsuura, Yasunori; Hayashi, Takaaki The Journal of Antibiotics, Vol. 69, Issue 7 https://doi.org/10.1038/ja.2016.40	journal	April 2016
Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina) Martinez, Diego; Berka, Randy M.; Henrissat, Bernard Nature Biotechnology, Vol. 26, Issue 5 https://doi.org/10.1038/nbt1403	journal	May 2008
Hidden biosynthetic treasures brought to light Hertweck, Christian Nature Chemical Biology, Vol. 5, Issue 7 https://doi.org/10.1038/nchembio0709-450	journal	July 2009
Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism Gupta, Simone; Ellis, Shannon E.; Ashar, Foram N. Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6748	journal	December 2014
Fungal secondary metabolism — from biochemistry to genomics Keller, Nancy P.; Turner, Geoffrey; Bennett, Joan W. Nature Reviews Microbiology, Vol. 3, Issue 12, p. 937-947 https://doi.org/10.1038/nrmicro1286	journal	December 2005
Trichoderma: the genomics of opportunistic success Druzhinina, Irina S.; Seidl-Seiboth, Verena; Herrera-Estrella, Alfredo Nature Reviews Microbiology, Vol. 9, Issue 10 https://doi.org/10.1038/nrmicro2637	journal	September 2011
Trichoderma species — opportunistic, avirulent plant symbionts Harman, Gary E.; Howell, Charles R.; Viterbo, Ada Nature Reviews Microbiology, Vol. 2, Issue 1 https://doi.org/10.1038/nrmicro797	journal	January 2004
Bis-naphthopyrone pigments protect filamentous ascomycetes from a wide range of predators Xu, Yang; Vinas, Maria; Alsarrag, Albatol Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-11377-5	journal	August 2019
Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance Spohn, Réka; Daruka, Lejla; Lázár, Viktória Nature Communications, Vol. 10, Issue 1 https://doi.org/10.1038/s41467-019-12364-6	journal	October 2019
Natural products in drug discovery: advances and opportunities Atanasov, Atanas G.; Zotchev, Sergey B.; Dirsch, Verena M. Nature Reviews Drug Discovery, Vol. 20, Issue 3 https://doi.org/10.1038/s41573-020-00114-z	journal	January 2021
Fungal secondary metabolism: regulation, function and drug discovery Keller, Nancy P. Nature Reviews Microbiology, Vol. 17, Issue 3 https://doi.org/10.1038/s41579-018-0121-1	journal	December 2018
SIRIUS 4: a rapid tool for turning tandem mass spectra into metabolite structure information Dührkop, Kai; Fleischauer, Markus; Ludwig, Marcus Nature Methods, Vol. 16, Issue 4 https://doi.org/10.1038/s41592-019-0344-8	journal	March 2019
Antifungal potential of secondary metabolites involved in the interaction between citrus pathogens Costa, Jonas Henrique; Wassano, Cristiane Izumi; Angolini, Célio Fernando Figueiredo Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-55204-9	journal	December 2019
A scoping review on incentives for adoption of sustainable agricultural practices and their outcomes Piñeiro, Valeria; Arias, Joaquín; Dürr, Jochen Nature Sustainability, Vol. 3, Issue 10 https://doi.org/10.1038/s41893-020-00617-y	journal	October 2020
The biosynthetic pathway for a thousand-year-old natural food colorant and citrinin in Penicillium marneffei Woo, Patrick C. Y.; Lam, Ching-Wan; Tam, Emily W. T. Scientific Reports, Vol. 4, Issue 1 https://doi.org/10.1038/srep06728	journal	October 2014
Potential of the beneficial fungus Trichoderma to enhance ecosystem-service provision in the biofuel grass Miscanthus x giganteus in agriculture Chirino-Valle, Ivan; Kandula, Diwakar; Littlejohn, Chris Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep25109	journal	April 2016
Tenellin and bassianin, metabolites of Beauveria species. Structure elucidation with 15N- and doubly 13C-enriched compounds using 13C nuclear magnetic resonance spectroscopy Mcinnes, A. Gavin; Smith, Donald G.; Wat, Chi-Kit Journal of the Chemical Society, Chemical Communications, Issue 8 https://doi.org/10.1039/C39740000281	journal	January 1974
Chemoselective enrichment for natural products discovery Odendaal, Antoinette Y.; Trader, Darci J.; Carlson, Erin E. Chemical Science, Vol. 2, Issue 4 https://doi.org/10.1039/c0sc00620c	journal	January 2011
Natural product isolation – how to get from biological material to pure compounds Bucar, Franz; Wube, Abraham; Schmid, Martin Natural Product Reports, Vol. 30, Issue 4 https://doi.org/10.1039/c3np20106f	journal	January 2013
One pathway, many compounds: heterologous expression of a fungal biosynthetic pathway reveals its intrinsic potential for diversity Wasil, Zahida; Pahirulzaman, Khomaizon A. K.; Butts, Craig Chemical Science, Vol. 4, Issue 10 https://doi.org/10.1039/c3sc51785c	journal	January 2013
Fungal siderophore metabolism with a focus on Aspergillus fumigatus Haas, Hubertus Nat. Prod. Rep., Vol. 31, Issue 10 https://doi.org/10.1039/c4np00071d	journal	January 2014
Identification of genes encoding squalestatin S1 biosynthesis and in vitro production of new squalestatin analogues Bonsch, B.; Belt, V.; Bartel, C. Chemical Communications, Vol. 52, Issue 41 https://doi.org/10.1039/c6cc02130a	journal	January 2016
Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: validation of their authenticity via in situ chemical analysis Rivera-Chávez, José; Raja, Huzefa A.; Graf, Tyler N. RSC Adv., Vol. 7, Issue 72 https://doi.org/10.1039/c7ra09602j	journal	January 2017
Oxidative steps during the biosynthesis of squalestatin S1 Lebe, Karen E.; Cox, Russell J. Chemical Science, Vol. 10, Issue 4 https://doi.org/10.1039/c8sc02615g	journal	January 2019
Biosynthetic gene clusters and the evolution of fungal chemodiversity Rokas, Antonis; Mead, Matthew E.; Steenwyk, Jacob L. Natural Product Reports, Vol. 37, Issue 7 https://doi.org/10.1039/c9np00045c	journal	January 2020
Molecular methods unravel the biosynthetic potential of Trichoderma species Shenouda, Mary L.; Cox, Russell J. RSC Advances, Vol. 11, Issue 6 https://doi.org/10.1039/d0ra09627j	journal	January 2021
The nature and mode of action of the cellulolytic component C1 of Trichoderma koningii on native cellulose Halliwell, G.; Griffin, M. Biochemical Journal, Vol. 135, Issue 4 https://doi.org/10.1042/bj1350587	journal	December 1973
Designs for greenhouse studies of interactions between plants Gibson, David. J.; Connolly, John; Hartnett, David. C. Journal of Ecology, Vol. 87, Issue 1 https://doi.org/10.1046/j.1365-2745.1999.00321.x	journal	January 1999
Interspecific hybridization in plant‐associated fungi and oomycetes: a review Schardl, C. L.; Craven, K. D. Molecular Ecology, Vol. 12, Issue 11 https://doi.org/10.1046/j.1365-294X.2003.01965.x	journal	September 2003
Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi Toyomasu, T.; Tsukahara, M.; Kaneko, A. Proceedings of the National Academy of Sciences, Vol. 104, Issue 9 https://doi.org/10.1073/pnas.0608426104	journal	February 2007
Sexual development in the industrial workhorse Trichoderma reesei Seidl, V.; Seibel, C.; Kubicek, C. P. Proceedings of the National Academy of Sciences, Vol. 106, Issue 33 https://doi.org/10.1073/pnas.0904936106	journal	August 2009
Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants Geisler, K.; Hughes, R. K.; Sainsbury, F. Proceedings of the National Academy of Sciences, Vol. 110, Issue 35 https://doi.org/10.1073/pnas.1309157110	journal	August 2013
Horizontal gene transfer and gene dosage drives adaptation to wood colonization in a tree pathogen Dhillon, Braham; Feau, Nicolas; Aerts, Andrea L. Proceedings of the National Academy of Sciences, Vol. 112, Issue 11 https://doi.org/10.1073/pnas.1424293112	journal	March 2015
Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity Snarr, Brendan D.; Baker, Perrin; Bamford, Natalie C. Proceedings of the National Academy of Sciences, Vol. 114, Issue 27 https://doi.org/10.1073/pnas.1702798114	journal	June 2017
Genome mining and biosynthesis of a polyketide from a biofertilizer fungus that can facilitate reductive iron assimilation in plant Chen, Mengbin; Liu, Qikun; Gao, Shu-Shan Proceedings of the National Academy of Sciences, Vol. 116, Issue 12 https://doi.org/10.1073/pnas.1819998116	journal	March 2019
Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes Kroken, S.; Glass, N. L.; Taylor, J. W. Proceedings of the National Academy of Sciences, Vol. 100, Issue 26 https://doi.org/10.1073/pnas.2532165100	journal	December 2003
Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Bergstrom, J. D.; Kurtz, M. M.; Rew, D. J. Proceedings of the National Academy of Sciences, Vol. 90, Issue 1 https://doi.org/10.1073/pnas.90.1.80	journal	January 1993
PEAKS DB: De Novo Sequencing Assisted Database Search for Sensitive and Accurate Peptide Identification Zhang, Jing; Xin, Lei; Shan, Baozhen Molecular & Cellular Proteomics, Vol. 11, Issue 4 https://doi.org/10.1074/mcp.M111.010587	journal	December 2011
Review of strobilurin fungicide chemicals Balba, Hamdy Journal of Environmental Science and Health, Part B, Vol. 42, Issue 4 https://doi.org/10.1080/03601230701316465	journal	May 2007
Genetic improvement of fungi by protoplast fusion for biological control of plant pathogens Stasz, Thomas E. Canadian Journal of Plant Pathology, Vol. 12, Issue 3 https://doi.org/10.1080/07060669009501007	journal	September 1990
Potential of Trichoderma spp., Bacillus subtilis and Pseudomonas fluorescens in the management of early blight in tomato Kulimushi, Séraphin M.; Muiru, William M.; Mutitu, Eunice W. Biocontrol Science and Technology, Vol. 31, Issue 9 https://doi.org/10.1080/09583157.2021.1900784	journal	March 2021
Secondary metabolites from the red mould rice of Monascus purpureus BCRC 38113 Cheng, Ming-Jen; Wu, Ming-Der; Chen, Ih-Sheng Natural Product Research, Vol. 24, Issue 18 https://doi.org/10.1080/14786410902941477	journal	November 2010
A practical guide to fungal genome projects: strategy, technology, cost and completion Ma, Li-Jun; Fedorova, Natalie D. Mycology, Vol. 1, Issue 1 https://doi.org/10.1080/21501201003680943	journal	March 2010
Studies on a Bactericidal Agent Extracted from a soil Bacillus Dubos, René J. Journal of Experimental Medicine, Vol. 70, Issue 1 https://doi.org/10.1084/jem.70.1.1	journal	July 1939
Studies on a Bactericidal Agent Extracted from a soil Bacillus Dubos, René J.; Cattaneo, Carlo Journal of Experimental Medicine, Vol. 70, Issue 3 https://doi.org/10.1084/jem.70.3.249	journal	September 1939
(Post-)Genomics approaches in fungal research Aguilar-Pontes, M. V.; de Vries, R. P.; Zhou, M. Briefings in Functional Genomics, Vol. 13, Issue 6 https://doi.org/10.1093/bfgp/elu028	journal	July 2014
Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides Xu, Jing; Li, Fuyi; Leier, André Briefings in Bioinformatics, Vol. 22, Issue 5 https://doi.org/10.1093/bib/bbab083	journal	March 2021
Bioinformatics tools for the identification of gene clusters that biosynthesize specialized metabolites Chavali, Arvind K.; Rhee, Seung Y. Briefings in Bioinformatics, Vol. 19, Issue 5 https://doi.org/10.1093/bib/bbx020	journal	April 2017
amPEPpy 1.0: a portable and accurate antimicrobial peptide prediction tool Lawrence, Travis J.; Carper, Dana L.; Spangler, Margaret K. Bioinformatics, Vol. 37, Issue 14 https://doi.org/10.1093/bioinformatics/btaa917	journal	November 2020
Ecological functions of Trichoderma spp. and their secondary metabolites in the rhizosphere: interactions with plants Contreras-Cornejo, Hexon Angel; Macías-Rodríguez, Lourdes; del-Val, Ek FEMS Microbiology Ecology, Vol. 92, Issue 4 https://doi.org/10.1093/femsec/fiw036	journal	February 2016
Comparative Genomics Provide Insights into Evolution of Trichoderma Nutrition Style Xie, Bin-Bin; Qin, Qi-Long; Shi, Mei Genome Biology and Evolution, Vol. 6, Issue 2 https://doi.org/10.1093/gbe/evu018	journal	January 2014
Microbial interactions and biocontrol in the rhizosphere Whipps, J. M. Journal of Experimental Botany, Vol. 52, Issue suppl 1 https://doi.org/10.1093/jexbot/52.suppl_1.487	journal	March 2001
The New Integrated Pest Management Paradigm for the Modern Age Dara, Surendra K. Journal of Integrated Pest Management, Vol. 10, Issue 1 https://doi.org/10.1093/jipm/pmz010	journal	January 2019
Metabolite profiling of fungi and yeast: from phenotype to metabolome by MS and informatics Smedsgaard, Jørn; Nielsen, Jens Journal of Experimental Botany, Vol. 56, Issue 410 https://doi.org/10.1093/jxb/eri068	journal	December 2004
Differential Retention of Gene Functions in a Secondary Metabolite Cluster Reynolds, Hannah T.; Slot, Jason C.; Divon, Hege H. Molecular Biology and Evolution, Vol. 34, Issue 8 https://doi.org/10.1093/molbev/msx145	journal	April 2017
Pfam: The protein families database in 2021 Mistry, Jaina; Chuguransky, Sara; Williams, Lowri Nucleic Acids Research, Vol. 49, Issue D1 https://doi.org/10.1093/nar/gkaa913	journal	October 2020
NORINE: a database of nonribosomal peptides Caboche, S.; Pupin, M.; Leclere, V. Nucleic Acids Research, Vol. 36, Issue Database https://doi.org/10.1093/nar/gkm792	journal	December 2007
MycoCosm portal: gearing up for 1000 fungal genomes Grigoriev, Igor V.; Nikitin, Roman; Haridas, Sajeet Nucleic Acids Research, Vol. 42, Issue D1 https://doi.org/10.1093/nar/gkt1183	journal	December 2013
APD3: the antimicrobial peptide database as a tool for research and education Wang, Guangshun; Li, Xia; Wang, Zhe Nucleic Acids Research, Vol. 44, Issue D1 https://doi.org/10.1093/nar/gkv1278	journal	November 2015
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline Blin, Kai; Shaw, Simon; Steinke, Katharina Nucleic Acids Research, Vol. 47, Issue W1 https://doi.org/10.1093/nar/gkz310	journal	April 2019
Networks Newman, Mark Oxford Scholarship Online https://doi.org/10.1093/oso/9780198805090.001.0001	book	July 2018
The Ascomycota Tree of Life: A Phylum-wide Phylogeny Clarifies the Origin and Evolution of Fundamental Reproductive and Ecological Traits Schoch, Conrad L.; Sung, Gi-Ho; López-Giráldez, Francesc Systematic Biology, Vol. 58, Issue 2 https://doi.org/10.1093/sysbio/syp020	journal	April 2009
Near-Complete Genomes of Two Trichoderma Species: A Resource for Biological Control of Plant Pathogens Zhou, Yi; Wang, Yilian; Chen, Kai Molecular Plant-Microbe Interactions®, Vol. 33, Issue 8 https://doi.org/10.1094/MPMI-03-20-0076-A	journal	August 2020
Mechanisms Employed by Trichoderma Species in the Biological Control of Plant Diseases: The History and Evolution of Current Concepts Howell, C. R. Plant Disease, Vol. 87, Issue 1 https://doi.org/10.1094/PDIS.2003.87.1.4	journal	January 2003
The Role of Hybridization in the Evolution and Emergence of New Fungal Plant Pathogens Stukenbrock, Eva H. Phytopathology®, Vol. 106, Issue 2 https://doi.org/10.1094/PHYTO-08-15-0184-RVW	journal	February 2016
Transformants of Trichoderma longibrachiatum Overexpressing the β-1,4-Endoglucanase Gene egl1 Show Enhanced Biocontrol of Pythium ultimum on Cucumber Migheli, Quirico; González-Candelas, Luis; Dealessi, Laura Phytopathology, Vol. 88, Issue 7 https://doi.org/10.1094/PHYTO.1998.88.7.673	journal	July 1998
Elicitors of Plant Defense Responses from Biocontrol Strains of Trichoderma viren Hanson, L. E.; Howell, C. R. Phytopathology®, Vol. 94, Issue 2 https://doi.org/10.1094/PHYTO.2004.94.2.171	journal	February 2004
Biological control and sustainable food production Bale, J. S.; van Lenteren, J. C.; Bigler, F. Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 363, Issue 1492 https://doi.org/10.1098/rstb.2007.2182	journal	September 2007
Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens Shi, Mei; Chen, Lei; Wang, Xiao-Wei Microbiology, Vol. 158, Issue 1 https://doi.org/10.1099/mic.0.052670-0	journal	January 2012
Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma Baker, S. E.; Perrone, G.; Richardson, N. M. Microbiology, Vol. 158, Issue 1 https://doi.org/10.1099/mic.0.053462-0	journal	November 2011
Secondary metabolism in Trichoderma - a genomic perspective Mukherjee, P. K.; Horwitz, B. A.; Kenerley, C. M. Microbiology, Vol. 158, Issue 1 https://doi.org/10.1099/mic.0.053629-0	journal	October 2011
Alternative reproductive strategies of Hypocrea orientalis and genetically close but clonal Trichoderma longibrachiatum, both capable of causing invasive mycoses of humans Druzhinina, Irina S.; Komoń-Zelazowska, Monika; Kredics, László Microbiology, Vol. 154, Issue 11 https://doi.org/10.1099/mic.0.2008/021196-0	journal	November 2008
Communicability across evolving networks Grindrod, Peter; Parsons, Mark C.; Higham, Desmond J. Physical Review E, Vol. 83, Issue 4 https://doi.org/10.1103/PhysRevE.83.046120	journal	April 2011
Production of a fungal furocoumarin by a polyketide synthase gene cluster confers the chemo-resistance of Neurospora crassa to the predation by fungivorous arthropods: Production of a fungal furocoumarin Zhao, Yanxia; Ding, Jianing; Yuan, Weihua Environmental Microbiology, Vol. 19, Issue 10 https://doi.org/10.1111/1462-2920.13791	journal	May 2017
Technologies for Extraction and Production of Bioactive Compounds to be Used as Nutraceuticals and Food Ingredients: An Overview: Production of nutraceutical compounds: A review… Joana Gil-Chávez, G.; Villa, José A.; Fernando Ayala-Zavala, J. Comprehensive Reviews in Food Science and Food Safety, Vol. 12, Issue 1 https://doi.org/10.1111/1541-4337.12005	journal	January 2013
Genetic engineering of Trichoderma reesei cellulases and their production Druzhinina, Irina S.; Kubicek, Christian P. Microbial Biotechnology, Vol. 10, Issue 6 https://doi.org/10.1111/1751-7915.12726	journal	May 2017
Hybridization of Neotyphodium endophytes enhances competitive ability of the host grass Saari, S.; Faeth, S. H. New Phytologist, Vol. 195, Issue 1 https://doi.org/10.1111/j.1469-8137.2012.04140.x	journal	April 2012
Broad-spectrum antimicrobial activity and high stability of Trichokonins from Trichoderma koningii SMF2 against plant pathogens Xiao-Yan, Song; Qing-Tao, Shen; Shu-Tao, Xie FEMS Microbiology Letters, Vol. 260, Issue 1 https://doi.org/10.1111/j.1574-6968.2006.00316.x	journal	July 2006
Antimicrobial peptides and plant disease control Montesinos, Emilio FEMS Microbiology Letters, Vol. 270, Issue 1, p. 1-11 https://doi.org/10.1111/j.1574-6968.2007.00683.x	journal	May 2007
Screening, identification and evaluation of potential biocontrol fungal endophytes against Rhizoctonia solani AG3 on potato plants: Biocontrol of Rhizoctonia solani using fungal endophytes Lahlali, Rachid; Hijri, Mohamed FEMS Microbiology Letters, Vol. 311, Issue 2 https://doi.org/10.1111/j.1574-6968.2010.02084.x	journal	August 2010
Asperfuranone from Aspergillus nidulans Inhibits Proliferation of Human Non-Small Cell Lung Cancer A549 Cells via Blocking Cell Cycle Progression and Inducing Apoptosis: ASPERFURANONE FROM ASPERGILLUS NIDULANS INHIBITS PROLIFERATION OF HUMAN NSCLC Wang, Clay C. C.; Chiang, Yi-Ming; Praseuth, Mike B. Basic & Clinical Pharmacology & Toxicology, Vol. 107, Issue 1 https://doi.org/10.1111/j.1742-7843.2010.00545.x	journal	February 2010
Mechanisms of Action of Mycophenolic Acid Allison, Anthony C.; Kowalski, W. Joseph; Muller, Christian D. Annals of the New York Academy of Sciences, Vol. 696, Issue 1 https://doi.org/10.1111/j.1749-6632.1993.tb17143.x	journal	November 1993
Botrydial and botcinins produced by B otrytis cinerea regulate the expression of T richoderma arundinaceum genes involved in trichothecene biosynthesis: Fungal metabolite cross-regulation Malmierca, Mónica G.; Izquierdo-Bueno, Inmaculada; Mccormick, Susan P. Molecular Plant Pathology, Vol. 17, Issue 7 https://doi.org/10.1111/mpp.12343	journal	February 2016
FoEG1, a secreted glycoside hydrolase family 12 protein from Fusarium oxysporum , triggers cell death and modulates plant immunity Zhang, Lin; Yan, Jianpei; Fu, Zhenchao Molecular Plant Pathology, Vol. 22, Issue 5 https://doi.org/10.1111/mpp.13041	journal	March 2021
Effects of natural hybrid and non‐hybrid Epichloë endophytes on the response of Hordelymus europaeus to drought stress Oberhofer, Martina; Güsewell, Sabine; Leuchtmann, Adrian New Phytologist, Vol. 201, Issue 1 https://doi.org/10.1111/nph.12496	journal	September 2013
Fungal‐based bioherbicides for weed control: a myth or a reality? Triolet, M.; Guillemin, J‐P; Andre, O. Weed Research, Vol. 60, Issue 1 https://doi.org/10.1111/wre.12389	journal	November 2019
Identification of Loci and Functional Characterization of Trichothecene Biosynthesis Genes in Filamentous Fungi of the Genus Trichoderma Cardoza, R. E.; Malmierca, M. G.; Hermosa, M. R. Applied and Environmental Microbiology, Vol. 77, Issue 14 https://doi.org/10.1128/AEM.00595-11	journal	July 2011
Biosynthesis of the Pharmaceutically Important Fungal Ergot Alkaloid Dihydrolysergic Acid Requires a Specialized Allele of cloA Arnold, Stephanie L.; Panaccione, Daniel G. Applied and Environmental Microbiology, Vol. 83, Issue 14 https://doi.org/10.1128/AEM.00805-17	journal	July 2017
Clonal Species Trichoderma parareesei sp. nov. Likely Resembles the Ancestor of the Cellulase Producer Hypocrea jecorina/T. reesei Atanasova, L.; Jaklitsch, W. M.; Komon-Zelazowska, M. Applied and Environmental Microbiology, Vol. 76, Issue 21 https://doi.org/10.1128/AEM.01184-10	journal	September 2010
Identifying Beneficial Qualities of Trichoderma parareesei for Plants Rubio, M. Belén; Quijada, Narciso M.; Pérez, Esclaudys Applied and Environmental Microbiology, Vol. 80, Issue 6 https://doi.org/10.1128/AEM.03375-13	journal	March 2014
The Family-3 Glycoside Hydrolases: from Housekeeping Functions to Host-Microbe Interactions Faure, Denis Applied and Environmental Microbiology, Vol. 68, Issue 4 https://doi.org/10.1128/AEM.68.4.1485-1490.2002	journal	April 2002
Mellein and 4-Hydroxymellein Production by Aspergillus ochraceus Wilhelm1 Moore, Jack H.; Davis, Norman D.; Diener, Urban L. Applied Microbiology, Vol. 23, Issue 6 https://doi.org/10.1128/aem.23.6.1067-1072.1972	journal	January 1972
Evaluation of alternariol and alternariol methyl ether for mutagenic activity in Salmonella typhimurium Davis, V. M.; Stack, M. E. Applied and Environmental Microbiology, Vol. 60, Issue 10 https://doi.org/10.1128/aem.60.10.3901-3902.1994	journal	October 1994
First Whole-Genome Shotgun Sequence of a Promising Cellulase Secretor, Trichoderma koningiopsis Strain POS7 Castrillo, María Lorena; Bich, Gustavo Ángel; Modenutti, Carlos Genome Announcements, Vol. 5, Issue 37 https://doi.org/10.1128/genomeA.00823-17	journal	September 2017
Genome Sequence and Annotation of Trichoderma parareesei , the Ancestor of the Cellulase Producer Trichoderma reesei Yang, Dongqing; Pomraning, Kyle; Kopchinskiy, Alexey Genome Announcements, Vol. 3, Issue 4 https://doi.org/10.1128/genomeA.00885-15	journal	August 2015
Draft Genome Sequences of Several Fungal Strains Selected for Exposure to Microgravity at the International Space Station Singh, Nitin K.; Blachowicz, Adriana; Romsdahl, Jillian Genome Announcements, Vol. 5, Issue 15 https://doi.org/10.1128/genomeA.01602-16	journal	April 2017
Draft Whole-Genome Sequence of Trichoderma gamsii T6085, a Promising Biocontrol Agent of Fusarium Head Blight on Wheat Baroncelli, Riccardo; Zapparata, Antonio; Piaggeschi, Giulia Genome Announcements, Vol. 4, Issue 1 https://doi.org/10.1128/genomeA.01747-15	journal	February 2016
Antimicrobial Peptides: a New Frontier in Antifungal Therapy Buda De Cesare, Giuseppe; Cristy, Shane A.; Garsin, Danielle A. mBio, Vol. 11, Issue 6 https://doi.org/10.1128/mBio.02123-20	journal	December 2020
Phytotoxic Tryptoquialanines Produced In Vivo by Penicillium digitatum Are Exported in Extracellular Vesicles Costa, Jonas Henrique; Bazioli, Jaqueline Moraes; Barbosa, Luidy Darllan mBio, Vol. 12, Issue 1 https://doi.org/10.1128/mBio.03393-20	journal	February 2021
The Fungal Tree of Life: from Molecular Systematics to Genome-Scale Phylogenies Spatafora, Joseph W.; Aime, M. Catherine; Grigoriev, Igor V. Microbiology Spectrum, Vol. 5, Issue 5 https://doi.org/10.1128/microbiolspec.funk-0053-2016	journal	October 2017
Sequencing and Analysis of the Entire Genome of the Mycoparasitic Fungus Trichoderma afroharzianum Landeis, Anastasia; Schmidt-Heydt, Markus Microbiology Resource Announcements, Vol. 10, Issue 15 https://doi.org/10.1128/mra.00211-21	journal	April 2021
A low-molecular mass antimicrobial peptide from Trichoderma cf. aureoviride Rifai VKM F-4268D Arinbasarova, A. Yu.; Baskunov, B. P.; Medentsev, A. G. Microbiology, Vol. 86, Issue 2 https://doi.org/10.1134/S0026261717020059	journal	March 2017
Metabolites of Trichoderma species isolated from damp building materials McMullin, David R.; Renaud, Justin B.; Barasubiye, Tharcisse Canadian Journal of Microbiology, Vol. 63, Issue 7 https://doi.org/10.1139/cjm-2017-0083	journal	July 2017
Trichoderma cyanodichotomus sp. nov., a new soil-inhabiting species with a potential for biological control Li, Jishun; Wu, Yuanzheng; Chen, Kai Canadian Journal of Microbiology, Vol. 64, Issue 12 https://doi.org/10.1139/cjm-2018-0224	journal	December 2018
Regulation and Role of Fungal Secondary Metabolites Macheleidt, Juliane; Mattern, Derek J.; Fischer, Juliane Annual Review of Genetics, Vol. 50, Issue 1 https://doi.org/10.1146/annurev-genet-120215-035203	journal	November 2016
Translational Research on Trichoderma : From 'Omics to the Field Lorito, Matteo; Woo, Sheridan L.; Harman,, Gary E. Annual Review of Phytopathology, Vol. 48, Issue 1 https://doi.org/10.1146/annurev-phyto-073009-114314	journal	July 2010
Biosynthesis of Nonribosomal Peptides Finking, Robert; Marahiel, Mohamed A. Annual Review of Microbiology, Vol. 58, Issue 1, p. 453-488 https://doi.org/10.1146/annurev.micro.58.030603.123615	journal	October 2004
Role of Antibiosis in the Biocontrol of Plant Diseases* Fravel, D. R. Annual Review of Phytopathology, Vol. 26, Issue 1 https://doi.org/10.1146/annurev.py.26.090188.000451	journal	September 1988
Origin and distribution of epipolythiodioxopiperazine (ETP) gene clusters in filamentous ascomycetes Patron, Nicola J.; Waller, Ross F.; Cozijnsen, Anton J. BMC Evolutionary Biology, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2148-7-174	journal	January 2007
Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi Khaldi, Nora; Collemare, Jérôme; Lebrun, Marc-Henri Genome Biology, Vol. 9, Issue 1 https://doi.org/10.1186/gb-2008-9-1-r18	journal	January 2008
Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine Zheng, Peng; Xia, Yongliang; Xiao, Guohua Genome Biology, Vol. 12, Issue 11 https://doi.org/10.1186/gb-2011-12-11-r116	journal	January 2011
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma Kubicek, Christian P.; Herrera-Estrella, Alfredo; Seidl-Seiboth, Verena Genome Biology, Vol. 12, Issue 4 https://doi.org/10.1186/gb-2011-12-4-r40	journal	April 2011
Identification of effector-like proteins in Trichoderma spp. and role of a hydrophobin in the plant-fungus interaction and mycoparasitism Guzmán-Guzmán, Paulina; Alemán-Duarte, Mario Iván; Delaye, Luis BMC Genetics, Vol. 18, Issue 1 https://doi.org/10.1186/s12863-017-0481-y	journal	February 2017
Genomic characterization of Trichoderma atrobrunneum (T. harzianum species complex) ITEM 908: insight into the genetic endowment of a multi-target biocontrol strain Fanelli, Francesca; Liuzzi, Vania Cosma; Logrieco, Antonio Francesco BMC Genomics, Vol. 19, Issue 1 https://doi.org/10.1186/s12864-018-5049-3	journal	September 2018
Evolution and comparative genomics of the most common Trichoderma species Kubicek, Christian P.; Steindorff, Andrei S.; Chenthamara, Komal BMC Genomics, Vol. 20, Issue 1 https://doi.org/10.1186/s12864-019-5680-7	journal	June 2019
Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723 Sinha, Swati; Nge, Choy-Eng; Leong, Chung Yan BMC Genomics, Vol. 20, Issue 1 https://doi.org/10.1186/s12864-019-5762-6	journal	May 2019
The antibiotic peptaibol alamethicin from Trichoderma permeabilises Arabidopsis root apical meristem and epidermis but is antagonised by cellulase-induced resistance to alamethicin Dotson, Bradley R.; Soltan, Dia; Schmidt, John BMC Plant Biology, Vol. 18, Issue 1 https://doi.org/10.1186/s12870-018-1370-x	journal	August 2018
Fast gene disruption in Trichoderma reesei using in vitro assembled Cas9/gRNA complex Hao, Zhenzhen; Su, Xiaoyun BMC Biotechnology, Vol. 19, Issue 1 https://doi.org/10.1186/s12896-018-0498-y	journal	January 2019
Methods for genetic transformation of filamentous fungi Li, Dandan; Tang, Yu; Lin, Jun Microbial Cell Factories, Vol. 16, Issue 1 https://doi.org/10.1186/s12934-017-0785-7	journal	October 2017
Techniques for extraction and isolation of natural products: a comprehensive review Zhang, Qing-Wen; Lin, Li-Gen; Ye, Wen-Cai Chinese Medicine, Vol. 13, Issue 1 https://doi.org/10.1186/s13020-018-0177-x	journal	April 2018
Two-step genomic sequence comparison strategy to design Trichoderma strain-specific primers for quantitative PCR Zhang, Yang; Wang, Xiang; Pang, Guan AMB Express, Vol. 9, Issue 1 https://doi.org/10.1186/s13568-019-0904-4	journal	November 2019
Volatile organic compounds emitted by Trichoderma species mediate plant growth Lee, Samantha; Yap, Melanie; Behringer, Gregory Fungal Biology and Biotechnology, Vol. 3, Issue 1 https://doi.org/10.1186/s40694-016-0025-7	journal	September 2016
Trichoderma: a beneficial antifungal agent and insights into its mechanism of biocontrol potential Mukhopadhyay, Ria; Kumar, Deepak Egyptian Journal of Biological Pest Control, Vol. 30, Issue 1 https://doi.org/10.1186/s41938-020-00333-x	journal	October 2020
Fungal clones win the battle, but recombination wins the war Drenth, André; McTaggart, Alistair R.; Wingfield, Brenda D. IMA Fungus, Vol. 10, Issue 1 https://doi.org/10.1186/s43008-019-0020-8	journal	October 2019
Beneficial Microorganisms: Countering Microbephobia Stark, Louisa A. CBE—Life Sciences Education, Vol. 9, Issue 4 https://doi.org/10.1187/cbe.10-09-0119	journal	December 2010
Fungal Metabolites. XIII. Isolation and Structural Elucidation of New Peptaibols, Trichodecenins-I and -II, from Trichoderma viride. Fujita, Tetsuro; Wada, Shun-ichi; Iida, Akira Chemical and Pharmaceutical Bulletin, Vol. 42, Issue 3 https://doi.org/10.1248/cpb.42.489	journal	January 1994
Studies on Metabolites of Mycoparasitic Fungi. IV. Minor Peptaibols of Trichoderma koningii. Huang, Qing; Tezuka, Yasuhiro; Hatanaka, Yasumaru Chemical and Pharmaceutical Bulletin, Vol. 43, Issue 10 https://doi.org/10.1248/cpb.43.1663	journal	January 1995
Fusarium Mycotoxins (Fumonisins, Nivalenol, and Zearalenone) and Aflatoxins in Corn from Southeast Asia Yamashita, Akihiro; Yoshizawa, Takumi; Aiura, Yusuke Bioscience, Biotechnology, and Biochemistry, Vol. 59, Issue 9 https://doi.org/10.1271/bbb.59.1804	journal	January 1995
Genetically Modified Corn— Environmental Benefits and Risks Gewin, Virginia PLoS Biology, Vol. 1, Issue 1 https://doi.org/10.1371/journal.pbio.0000008	journal	October 2003
Glycoside Hydrolases across Environmental Microbial Communities Berlemont, Renaud; Martiny, Adam C. PLOS Computational Biology, Vol. 12, Issue 12 https://doi.org/10.1371/journal.pcbi.1005300	journal	December 2016
Massive lateral transfer of genes encoding plant cell wall-degrading enzymes to the mycoparasitic fungus Trichoderma from its plant-associated hosts Druzhinina, Irina S.; Chenthamara, Komal; Zhang, Jian PLOS Genetics, Vol. 14, Issue 4 https://doi.org/10.1371/journal.pgen.1007322	journal	April 2018
Ancient Horizontal Gene Transfer from Bacteria Enhances Biosynthetic Capabilities of Fungi Schmitt, Imke; Lumbsch, H. Thorsten PLoS ONE, Vol. 4, Issue 2 https://doi.org/10.1371/journal.pone.0004437	journal	February 2009
Evolution and Ecophysiology of the Industrial Producer Hypocrea jecorina (Anamorph Trichoderma reesei) and a New Sympatric Agamospecies Related to It Druzhinina, Irina S.; Komoń-Zelazowska, Monika; Atanasova, Lea PLoS ONE, Vol. 5, Issue 2 https://doi.org/10.1371/journal.pone.0009191	journal	February 2010
Interkingdom Gene Transfer of a Hybrid NPS/PKS from Bacteria to Filamentous Ascomycota Lawrence, Daniel P.; Kroken, Scott; Pryor, Barry M. PLoS ONE, Vol. 6, Issue 11 https://doi.org/10.1371/journal.pone.0028231	journal	November 2011
Trypacidin, a Spore-Borne Toxin from Aspergillus fumigatus, Is Cytotoxic to Lung Cells Gauthier, Thierry; Wang, Xiaodi; Sifuentes Dos Santos, Joice PLoS ONE, Vol. 7, Issue 2 https://doi.org/10.1371/journal.pone.0029906	journal	February 2012
Production of Destruxins from Metarhizium spp. Fungi in Artificial Medium and in Endophytically Colonized Cowpea Plants Golo, Patrícia S.; Gardner, Dale R.; Grilley, Michelle M. PLoS ONE, Vol. 9, Issue 8 https://doi.org/10.1371/journal.pone.0104946	journal	August 2014
The Fusarium graminearum Genome Reveals More Secondary Metabolite Gene Clusters and Hints of Horizontal Gene Transfer Sieber, Christian M. K.; Lee, Wanseon; Wong, Philip PLoS ONE, Vol. 9, Issue 10 https://doi.org/10.1371/journal.pone.0110311	journal	October 2014
Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi Proctor, Robert H.; McCormick, Susan P.; Kim, Hye-Seon PLOS Pathogens, Vol. 14, Issue 4 https://doi.org/10.1371/journal.ppat.1006946	journal	April 2018
Trichosetin, a Novel Tetramic Acid Antibiotic Produced in Dual Culture of Trichoderma harzianum and Catharanthus roseus Callus Marfori, Eufrocinio C.; Kajiyama, Shin’ichiro; Fukusaki, Ei-ichiro Zeitschrift für Naturforschung C, Vol. 57, Issue 5-6 https://doi.org/10.1515/znc-2002-5-611	journal	June 2002
The impact and prospect of natural product discovery in agriculture: New technologies to explore the diversity of secondary metabolites in plants and microorganisms for applications in agriculture Yan, Yan; Liu, Qikun; Jacobsen, Steven E. EMBO reports, Vol. 19, Issue 11 https://doi.org/10.15252/embr.201846824	journal	October 2018
Species concepts and biodiversity in Trichoderma and Hypocrea : from aggregate species to species clusters? Druzhinina, Irina; Kubicek, Christian P. Journal of Zhejiang University SCIENCE, Vol. 6B, Issue 2 https://doi.org/10.1631/jzus.2005.B0100	journal	January 2005
Classification of the Mycoparasite Gliocladium roseum in Clonostachys as C. rosea, Its Relationship to Bionectria ochroleuca, and Notes on Other Gliocladium-like Fungi Schroers, Hans-Josef; Samuels, Gary J.; Seifert, Keith A. Mycologia, Vol. 91, Issue 2 https://doi.org/10.2307/3761383	journal	March 1999
Protoplast Preparation and Fusion in Two Biocontrol Strains of Trichoderma harzianum Stasz, T. E.; Harman, G. E.; Weeden, N. F. Mycologia, Vol. 80, Issue 2 https://doi.org/10.2307/3807788	journal	March 1988
Trichoderma spp. – application and prospects for use in organic farming and industry Błaszczyk, Lidia; Siwulski, Marek; Sobieralski, Krzysztof Journal of Plant Protection Research, Vol. 54, Issue 4 https://doi.org/10.2478/jppr-2014-0047	journal	December 2014
Safety and efficacy of muramidase from Trichoderma reesei DSM 32338 as a feed additive for chickens for fattening and minor poultry species Rychen, Guido; Aquilina, Gabriele; Azimonti, Giovanna EFSA Journal, Vol. 16, Issue 7 https://doi.org/10.2903/j.efsa.2018.5342	journal	July 2018
Trichoderma Afroharzianum Ear Rot–A New Disease on Maize in Europe Pfordt, Annette; Schiwek, Simon; Karlovsky, Petr Frontiers in Agronomy, Vol. 2 https://doi.org/10.3389/fagro.2020.547758	journal	September 2020
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents Mahlapuu, Margit; Håkansson, Joakim; Ringstad, Lovisa Frontiers in Cellular and Infection Microbiology, Vol. 6 https://doi.org/10.3389/fcimb.2016.00194	journal	December 2016
Fungi vs. Fungi in Biocontrol: An Overview of Fungal Antagonists Applied Against Fungal Plant Pathogens Thambugala, Kasun M.; Daranagama, Dinushani A.; Phillips, Alan J. L. Frontiers in Cellular and Infection Microbiology, Vol. 10 https://doi.org/10.3389/fcimb.2020.604923	journal	November 2020
In Vivo Study of the Sorbicillinoid Gene Cluster in Trichoderma reesei Derntl, Christian; Guzmán-Chávez, Fernando; Mello-de-Sousa, Thiago M. Frontiers in Microbiology, Vol. 8 https://doi.org/10.3389/fmicb.2017.02037	journal	October 2017
Volatile Compound-Mediated Recognition and Inhibition Between Trichoderma Biocontrol Agents and Fusarium oxysporum Li, Ningxiao; Alfiky, Alsayed; Wang, Wenzhao Frontiers in Microbiology, Vol. 9 https://doi.org/10.3389/fmicb.2018.02614	journal	October 2018
Trichoderma Species Differ in Their Volatile Profiles and in Antagonism Toward Ectomycorrhiza Laccaria bicolor Guo, Yuan; Ghirardo, Andrea; Weber, Baris Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.00891	journal	April 2019
A Conserved Glycoside Hydrolase Family 7 Cellobiohydrolase PsGH7a of Phytophthora sojae Is Required for Full Virulence on Soybean Tan, Xinwei; Hu, Yuyao; Jia, Yuli Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.01285	journal	July 2020
Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields Huan, Yuchen; Kong, Qing; Mou, Haijin Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.582779	journal	October 2020
Trichoderma reesei Isolated From Austrian Soil With High Potential for Biotechnological Application Hinterdobler, Wolfgang; Li, Guofen; Spiegel, Katharina Frontiers in Microbiology, Vol. 12 https://doi.org/10.3389/fmicb.2021.552301	journal	January 2021
MAMP (microbe-associated molecular pattern) triggered immunity in plants Newman, Mari-Anne; Sundelin, Thomas; Nielsen, Jon T. Frontiers in Plant Science, Vol. 4 https://doi.org/10.3389/fpls.2013.00139	journal	January 2013
Investigating the beneficial traits of Trichoderma hamatum GD12 for sustainable agriculture—insights from genomics Studholme, David J.; Harris, Beverley; Le Cocq, Kate Frontiers in Plant Science, Vol. 4 https://doi.org/10.3389/fpls.2013.00258	journal	January 2013
The food and environmental safety of Bt crops Koch, Michael S.; Ward, Jason M.; Levine, Steven L. Frontiers in Plant Science, Vol. 06 https://doi.org/10.3389/fpls.2015.00283	journal	April 2015
Is the efficacy of biological control against plant diseases likely to be more durable than that of chemical pesticides? Bardin, Marc; Ajouz, Sakhr; Comby, Morgane Frontiers in Plant Science, Vol. 6 https://doi.org/10.3389/fpls.2015.00566	journal	July 2015
Controlling weeds with fungi, bacteria and viruses: a review Harding, Dylan P.; Raizada, Manish N. Frontiers in Plant Science, Vol. 6 https://doi.org/10.3389/fpls.2015.00659	journal	August 2015
Mechanisms and Characterization of Trichoderma longibrachiatum T6 in Suppressing Nematodes (Heterodera avenae) in Wheat Zhang, Shuwu; Gan, Yantai; Ji, Weihong Frontiers in Plant Science, Vol. 8 https://doi.org/10.3389/fpls.2017.01491	journal	September 2017
Beneficial Services of Arbuscular Mycorrhizal Fungi – From Ecology to Application Chen, Min; Arato, Miguel; Borghi, Lorenzo Frontiers in Plant Science, Vol. 9 https://doi.org/10.3389/fpls.2018.01270	journal	September 2018
Mode of Action of Microbial Biological Control Agents Against Plant Diseases: Relevance Beyond Efficacy Köhl, Jürgen; Kolnaar, Rogier; Ravensberg, Willem J. Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.00845	journal	July 2019
Role of Arbuscular Mycorrhizal Fungi in Plant Growth Regulation: Implications in Abiotic Stress Tolerance Begum, Naheeda; Qin, Cheng; Ahanger, Muhammad Abass Frontiers in Plant Science, Vol. 10 https://doi.org/10.3389/fpls.2019.01068	journal	September 2019
Editorial: Biostimulants in Agriculture Rouphael, Youssef; Colla, Giuseppe Frontiers in Plant Science, Vol. 11 https://doi.org/10.3389/fpls.2020.00040	journal	February 2020
A Review of the Mycotoxin Enniatin B Prosperini, Alessandra; Berrada, Houda; Ruiz, María José Frontiers in Public Health, Vol. 5 https://doi.org/10.3389/fpubh.2017.00304	journal	November 2017
Combined Use of Two Trichoderma Strains to Promote Growth of Pakchoi (Brassica chinensis L.) Chen, Dawei; Hou, Qinzheng; Jia, Lingyun Agronomy, Vol. 11, Issue 4 https://doi.org/10.3390/agronomy11040726	journal	April 2021
Effects of Two Trichoderma Strains on Plant Growth, Rhizosphere Soil Nutrients, and Fungal Community of Pinus sylvestris var. mongolica Annual Seedlings Halifu, Saiyaremu; Deng, Xun; Song, Xiaoshuang Forests, Vol. 10, Issue 9 https://doi.org/10.3390/f10090758	journal	September 2019
Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2 Song, Yin-Ping; Miao, Feng-Ping; Fang, Sheng-Tao Marine Drugs, Vol. 16, Issue 8 https://doi.org/10.3390/md16080266	journal	August 2018
Heteroexpression of Aspergillus nidulans laeA in Marine-Derived Fungi Triggers Upregulation of Secondary Metabolite Biosynthetic Genes Khan, Ishrat; Xie, Wan-Lin; Yu, Yu-Chao Marine Drugs, Vol. 18, Issue 12 https://doi.org/10.3390/md18120652	journal	December 2020
A Historical Overview of Natural Products in Drug Discovery Dias, Daniel A.; Urban, Sylvia; Roessner, Ute Metabolites, Vol. 2, Issue 2 https://doi.org/10.3390/metabo2020303	journal	April 2012
Consistency, Inconsistency, and Ambiguity of Metabolite Names in Biochemical Databases Used for Genome-Scale Metabolic Modelling Pham, Nhung; van Heck, Ruben; van Dam, Jesse Metabolites, Vol. 9, Issue 2 https://doi.org/10.3390/metabo9020028	journal	February 2019
Non-Volatile Metabolites from Trichoderma spp. Li, Meng-Fei; Li, Guo-Hong; Zhang, Ke-Qin Metabolites, Vol. 9, Issue 3 https://doi.org/10.3390/metabo9030058	journal	March 2019
Fungal Pigments and Their Prospects in Different Industries Lagashetti, Ajay C.; Dufossé, Laurent; Singh, Sanjay K. Microorganisms, Vol. 7, Issue 12 https://doi.org/10.3390/microorganisms7120604	journal	November 2019
Genome Sequence of Trichoderma lixii MUT3171, A Promising Strain for Mycoremediation of PAH-Contaminated Sites Venice, Francesco; Davolos, Domenico; Spina, Federica Microorganisms, Vol. 8, Issue 9 https://doi.org/10.3390/microorganisms8091258	journal	August 2020
Combined Comparative Genomics and Gene Expression Analyses Provide Insights into the Terpene Synthases Inventory in Trichoderma Vicente, Isabel; Baroncelli, Riccardo; Morán-Diez, María Eugenia Microorganisms, Vol. 8, Issue 10 https://doi.org/10.3390/microorganisms8101603	journal	October 2020
Combining Biocontrol Agents with Chemical Fungicides for Integrated Plant Fungal Disease Control Ons, Lena; Bylemans, Dany; Thevissen, Karin Microorganisms, Vol. 8, Issue 12 https://doi.org/10.3390/microorganisms8121930	journal	December 2020
Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities Lu, Shiqiong; Tian, Jin; Sun, Weibo Molecules, Vol. 19, Issue 6 https://doi.org/10.3390/molecules19067169	journal	May 2014
Sorbicillinoids from Fungi and Their Bioactivities Meng, Jiajia; Wang, Xiaohan; Xu, Dan Molecules, Vol. 21, Issue 6 https://doi.org/10.3390/molecules21060715	journal	June 2016
Genome Sequencing of Paecilomyces Penicillatus Provides Insights into Its Phylogenetic Placement and Mycoparasitism Mechanisms on Morel Mushrooms Wang, Xinxin; Peng, Jingyu; Sun, Lei Pathogens, Vol. 9, Issue 10 https://doi.org/10.3390/pathogens9100834	journal	October 2020
Trichoderma: The “Secrets” of a Multitalented Biocontrol Agent Sood, Monika; Kapoor, Dhriti; Kumar, Vipul Plants, Vol. 9, Issue 6 https://doi.org/10.3390/plants9060762	journal	June 2020
Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum Shin, Jiyoung; Kim, Jung-Eun; Lee, Yin-Won Toxins, Vol. 10, Issue 3 https://doi.org/10.3390/toxins10030112	journal	March 2018
The case of the FLAVR SAVR tomato Bruening, G.; Lyons, J. M. California Agriculture, Vol. 54, Issue 4 https://doi.org/10.3733/ca.v054n04p6	journal	July 2000
Three new species of Trichoderma with hyaline ascospores from China Zhu, Z. X.; Zhuang, W. Y. Mycologia, Vol. 107, Issue 2 https://doi.org/10.3852/14-141	journal	March 2015
Systematics of the Trichoderma harzianum species complex and the re-identification of commercial biocontrol strains Chaverri, Priscila; Branco-Rocha, Fabiano; Jaklitsch, Walter Mycologia, Vol. 107, Issue 3 https://doi.org/10.3852/14-147	journal	May 2015
The Occurrence, Properties and Significance of Citrinin Mycotoxin Jh, Doughari Journal of Plant Pathology & Microbiology, Vol. 6, Issue 11 https://doi.org/10.4172/2157-7471.1000321	journal	January 2015
Westerdykella reniformis sp. nov., producing the antibiotic metabolites melinacidin IV and chetracin B Ebead, Ghada A.; Overy, David P.; Berrué, Fabrice IMA Fungus, Vol. 3, Issue 2 https://doi.org/10.5598/imafungus.2012.03.02.11	journal	December 2012
The strobilurins - New antifungal antibiotics from the basidiomycete Strobilurus tenacellus. Anke, T.; Oberwinkler, F.; Steglich, W. The Journal of Antibiotics, Vol. 30, Issue 10 https://doi.org/10.7164/antibiotics.30.806	journal	January 1977
A new sesquiterpene antibiotic, heptelidic acid Producing organisms, fermentation, isolation and characterization. Itoh, Yasuhiro; Kodama, Kentaro; Furuya, Kouhei The Journal of Antibiotics, Vol. 33, Issue 5 https://doi.org/10.7164/antibiotics.33.468	journal	January 1980
The structure of gliovirin, a new antibiotic from Gliocladium virens. Stipanovic, Robert D.; Howell, Charles R. The Journal of Antibiotics, Vol. 35, Issue 10 https://doi.org/10.7164/antibiotics.35.1326	journal	January 1982
The synthesis of compactin (ML-236B) and monacolin K in fungi. Endo, Akira; Hasumi, Keiji; Yamada, Akira The Journal of Antibiotics, Vol. 39, Issue 11 https://doi.org/10.7164/antibiotics.39.1609	journal	January 1986
Depudecin: A novel compound inducing the flat phenotype of NIH3T3 cells doubly transformed by ras- and src-oncogene, produced by Alternaria brassicicola. Matsumoto, Makoto; Matsutani, Shigeru; Sugita, Kenji The Journal of Antibiotics, Vol. 45, Issue 6 https://doi.org/10.7164/antibiotics.45.879	journal	January 1992
RES-1214-1 and -2, Novel Non-peptidic Endothelin Type A Receptor Antagonists Produced by Pestalotiopsis sp. Ogawa, Tatsuhiro; Ando, Katsuhiko; Aotani, Yumiko The Journal of Antibiotics, Vol. 48, Issue 12 https://doi.org/10.7164/antibiotics.48.1401	journal	January 1995

Similar Records

Genome Sequencing and Comparative Analysis of the Biocontrol Agent Trichoderma harzianum sensu stricto TR274

Conference · Tue Mar 17 00:00:00 EDT 2015 · OSTI ID:1235082

Phylogenomic analysis of polyketide synthase-encoding genes in Trichoderma

Journal Article · Sat Dec 31 23:00:00 EST 2011 · Microbiology · OSTI ID:1601800

Related Subjects

59 BASIC BIOLOGICAL SCIENCES

Bioprospecting Trichoderma: A Systematic Roadmap to Screen Genomes and Natural Products for Biocontrol Applications

Citation Formats

References (291)

Similar Records

Related Subjects