Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations

Li, Ailin; Nagy, Gabe; Conant, Christopher R.; Norheim, Randolph V.; Lee, Joon Yong; Giberson, Cameron; Hollerbach, Adam L.; Prabhakaran, Venkateshkumar; Attah, Isaac K.; Chouinard, Christopher D.; Prabhakaran, Aneesh; Smith, Richard D.; Ibrahim, Yehia M.; Garimella, Sandilya V.B.

doi:10.1021/acs.analchem.0c02100

Ion Mobility Spectrometry with High Ion Utilization Efficiency Using Traveling Wave-Based Structures for Lossless Ion Manipulations

Journal Article · Mon Oct 26 00:00:00 EDT 2020 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.0c02100· OSTI ID:1819086

Li, Ailin ^[1]; ^[1]; Conant, Christopher R. ^[1]; Norheim, Randolph V. ^[2]; ^[1]; Giberson, Cameron ^[1]; Hollerbach, Adam L. ^[1]; ^[1]; Attah, Isaac K. ^[1]; ^[1]; Prabhakaran, Aneesh ^[1]; ^[1]; ^[1]; ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL)

Ion packets introduced from gates, ion funnel traps, and other conventional ion injection mechanisms produce ion pulse widths typically around a few microseconds or less for ion mobility spectrometry (IMS)-based separations on the order of 100 milliseconds. When such ion injection techniques are coupled with ultralong path length traveling wave (TW)-based IMS separations (i.e., on the order of seconds) using structures for lossless ion manipulations (SLIMs), typically very low ion utilization efficiency is achieved for continuous ion sources [e.g., electrospray ionization (ESI)]. Even with the ability to trap and accumulate much larger populations of ions than being conventionally feasible over longer time periods in SLIM devices, the subsequent long separations lead to overall low ion utilization. In this study, we report the use of a highly flexible SLIM arrangement, enabling concurrent ion accumulation and separation and achieving near-complete ion utilization with ESI. We characterize the ion accumulation process in SLIM, demonstrate >98% ion utilization, and show both increased signal intensities and measurement throughput. This approach is envisioned to have broad utility to applications, for example, involving the fast detection of trace chemical species.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1819086

Report Number(s):: PNNL-SA--166146

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 22 Vol. 92; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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