Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors

Lemos, Danilo; Stuart, Jackson B.; Louie, William; Singapuri, Anil; Ramírez, Ana L.; Watanabe, Jennifer; Usachenko, Jodie; Keesler, Rebekah I.; Sanchez-San Martin, Claudia; Li, Tony; Martyn, Calla; Oliveira, Glenn; Saraf, Sharada; Grubaugh, Nathan D.; Andersen, Kristian G.; Thissen, James; Allen, Jonathan; Borucki, Monica; Tsetsarkin, Konstantin A.; Pletnev, Alexander G.; Chiu, Charles Y.; Van Rompay, Koen K.  A.; Coffey, Lark L.

doi:10.1128/JVI.01605-20

Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors

Journal Article · Mon Nov 23 00:00:00 EST 2020 · Journal of Virology

DOI:https://doi.org/10.1128/JVI.01605-20· OSTI ID:1817081

Lemos, Danilo ^[1]; Stuart, Jackson B. ^[2]; Louie, William ^[2]; Singapuri, Anil ^[2]; Ramírez, Ana L. ^[2]; Watanabe, Jennifer ^[3]; Usachenko, Jodie ^[4]; Keesler, Rebekah I. ^[4]; Sanchez-San Martin, Claudia ^[5]; Li, Tony ^[5]; Martyn, Calla ^[5]; Oliveira, Glenn ^[6]; Saraf, Sharada ^[6]; Grubaugh, Nathan D. ^[7]; Andersen, Kristian G. ^[6]; Thissen, James ^[8]; Allen, Jonathan ^[8]; Borucki, Monica ^[8]; Tsetsarkin, Konstantin A. ^[9]; Pletnev, Alexander G. ^[9] more »

Univ. of California, Davis, CA (United States). School of Veterinary Medicine. Dept. of Pathology, Microbiology and Immunology; OSTI
Univ. of California, Davis, CA (United States). School of Veterinary Medicine. Dept. of Pathology, Microbiology and Immunology
Univ. of California, Davis, CA (United States). California National Primate Research Center
Univ. of California, Davis, CA (United States). California National Primate Research Center
Univ. of California, San Francisco, CA (United States). Dept. of Lab. Medicine
Scripps Research Institute, San Diego, CA (United States)
Scripps Research Institute, San Diego, CA (United States); Yale Univ., New Haven, CT (United States). School of Public Health. Dept. of Epidemiology of Microbial Diseases
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
National Institutes of Health (NIH), Bethesda, MD (United States). National Institute of Allergy and Infectious Diseases. Lab. of Infectious Diseases

Although Zika virus infection of pregnant women can result in congenital Zika syndrome, the factors that cause the syndrome in some but not all infected mothers are still unclear. We identified a mutation that was present in some ZIKV genomes in experimentally inoculated pregnant rhesus macaques and their fetuses. Although we did not find an association between the presence of the mutation and fetal death, we performed additional studies with ZIKV with the mutation in nonpregnant macaques, pregnant mice, and mosquitoes. We observed that the mutation increased the ability of the virus to infect mouse fetuses but decreased its capacity to produce high levels of virus in the blood of nonpregnant macaques and to be transmitted by mosquitoes. This study shows that mutations in mosquito-borne viruses like ZIKV that increase fitness in pregnant vertebrates may not spread in outbreaks when they compromise transmission via mosquitoes and fitness in nonpregnant hosts.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); US Centers for Disease Control and Prevention (CDC); USDOE Office of Science (SC)

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1817081

Journal Information:: Journal of Virology, Journal Name: Journal of Virology Journal Issue: 24 Vol. 94; ISSN 0022-538X

Publisher:: American Society for MicrobiologyCopyright Statement

Country of Publication:: United States

Language:: English

References (68)

Procedure‐related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta‐analysis Akolekar, R.; Beta, J.; Picciarelli, G. Ultrasound in Obstetrics & Gynecology, Vol. 45, Issue 1 https://doi.org/10.1002/uog.14636	journal	November 2014
Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg?: Physician Alert Oliveira Melo, A. S.; Malinger, G.; Ximenes, R. Ultrasound in Obstetrics & Gynecology, Vol. 47, Issue 1 https://doi.org/10.1002/uog.15831	journal	January 2016
The spectrum of neuropathological changes associated with congenital Zika virus infection Chimelli, Leila; Melo, Adriana S. O.; Avvad-Portari, Elyzabeth Acta Neuropathologica, Vol. 133, Issue 6 https://doi.org/10.1007/s00401-017-1699-5	journal	March 2017
Pathology of congenital Zika syndrome in Brazil: a case series Martines, Roosecelis Brasil; Bhatnagar, Julu; de Oliveira Ramos, Ana Maria The Lancet, Vol. 388, Issue 10047 https://doi.org/10.1016/S0140-6736(16)30883-2	journal	August 2016
Congenital Zika virus syndrome in Brazil: a case series of the first 1501 livebirths with complete investigation França, Giovanny V. A.; Schuler-Faccini, Lavinia; Oliveira, Wanderson K. The Lancet, Vol. 388, Issue 10047 https://doi.org/10.1016/S0140-6736(16)30902-3	journal	August 2016
Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy Li, Yan; Li, Qingxin; Wong, Ying Lei Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1848, Issue 10 https://doi.org/10.1016/j.bbamem.2015.06.010	journal	October 2015
Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys Aid, Malika; Abbink, Peter; Larocca, Rafael A. Cell, Vol. 169, Issue 4 https://doi.org/10.1016/j.cell.2017.04.008	journal	May 2017
Zika Virus Targets Different Primary Human Placental Cells, Suggesting Two Routes for Vertical Transmission Tabata, Takako; Petitt, Matthew; Puerta-Guardo, Henry Cell Host & Microbe, Vol. 20, Issue 2 https://doi.org/10.1016/j.chom.2016.07.002	journal	August 2016
Zika Virus Pathogenesis and Tissue Tropism Miner, Jonathan J.; Diamond, Michael S. Cell Host & Microbe, Vol. 21, Issue 2 https://doi.org/10.1016/j.chom.2017.01.004	journal	February 2017
In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient Memoli, Matthew J.; Bristol, Tyler; Proudfoot, Kathleen E. Virology, Vol. 428, Issue 1 https://doi.org/10.1016/j.virol.2012.02.018	journal	June 2012
Quasispecies and its impact on viral hepatitis Domingo, Esteban; Gomez, Jordi Virus Research, Vol. 127, Issue 2 https://doi.org/10.1016/j.virusres.2007.02.001	journal	August 2007
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population Vignuzzi, Marco; Stone, Jeffrey K.; Arnold, Jamie J. Nature, Vol. 439, Issue 7074 https://doi.org/10.1038/nature04388	journal	December 2005
Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes Liu, Yang; Liu, Jianying; Du, Senyan Nature, Vol. 545, Issue 7655 https://doi.org/10.1038/nature22365	journal	May 2017
Zika virus evolution and spread in the Americas Metsky, Hayden C.; Matranga, Christian B.; Wohl, Shirlee Nature, Vol. 546, Issue 7658 https://doi.org/10.1038/nature22402	journal	May 2017
A rhesus macaque model of Asian-lineage Zika virus infection Dudley, Dawn M.; Aliota, Matthew T.; Mohr, Emma L. Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms12204	journal	June 2016
Intrauterine Zika virus infection of pregnant immunocompetent mice models transplacental transmission and adverse perinatal outcomes Vermillion, Meghan S.; Lei, Jun; Shabi, Yahya Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/ncomms14575	journal	February 2017
Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate Adams Waldorf, Kristina M.; Stencel-Baerenwald, Jennifer E.; Kapur, Raj P. Nature Medicine, Vol. 22, Issue 11 https://doi.org/10.1038/nm.4193	journal	September 2016
Zika viral dynamics and shedding in rhesus and cynomolgus macaques Osuna, Christa E.; Lim, So-Yon; Deleage, Claire Nature Medicine, Vol. 22, Issue 12 https://doi.org/10.1038/nm.4206	journal	October 2016
Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain Adams Waldorf, Kristina M.; Nelson, Branden R.; Stencel-Baerenwald, Jennifer E. Nature Medicine, Vol. 24, Issue 3 https://doi.org/10.1038/nm.4485	journal	February 2018
HIV evolution: CTL escape mutation and reversion after transmission Leslie, A. J.; Pfafferott, K. J.; Chetty, P. Nature Medicine, Vol. 10, Issue 3 https://doi.org/10.1038/nm992	journal	February 2004
Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples Quick, Joshua; Grubaugh, Nathan D.; Pullan, Steven T. Nature Protocols, Vol. 12, Issue 6 https://doi.org/10.1038/nprot.2017.066	journal	May 2017
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques Magnani, Diogo M.; Rogers, Thomas F.; Maness, Nicholas J. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04056-4	journal	April 2018
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease Coffey, Lark L.; Keesler, Rebekah I.; Pesavento, Patricia A. Nature Communications, Vol. 9, Issue 1 https://doi.org/10.1038/s41467-018-04777-6	journal	June 2018
Author Correction: Metagenomic sequencing with spiked primer enrichment for viral diagnostics and genomic surveillance Deng, Xianding; Achari, Asmeeta; Federman, Scot Nature Microbiology, Vol. 5, Issue 3 https://doi.org/10.1038/s41564-020-0671-7	journal	January 2020
We shouldn’t worry when a virus mutates during disease outbreaks Grubaugh, Nathan D.; Petrone, Mary E.; Holmes, Edward C. Nature Microbiology, Vol. 5, Issue 4 https://doi.org/10.1038/s41564-020-0690-4	journal	February 2020
Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates Dudley, Dawn M.; Van Rompay, Koen K.; Coffey, Lark L. Nature Medicine, Vol. 24, Issue 8 https://doi.org/10.1038/s41591-018-0088-5	journal	July 2018
Systematic evaluation of error rates and causes in short samples in next-generation sequencing Pfeiffer, Franziska; Gröber, Carsten; Blank, Michael Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-29325-6	journal	July 2018
Zika Virus Outbreak on Yap Island, Federated States of Micronesia Duffy, Mark R.; Chen, Tai-Ho; Hancock, W. Thane New England Journal of Medicine, Vol. 360, Issue 24 https://doi.org/10.1056/NEJMoa0805715	journal	June 2009
Zika Virus Associated with Microcephaly Mlakar, Jernej; Korva, Misa; Tul, Nataša New England Journal of Medicine, Vol. 374, Issue 10 https://doi.org/10.1056/NEJMoa1600651	journal	March 2016
Zika Virus Infection with Prolonged Maternal Viremia and Fetal Brain Abnormalities Driggers, Rita W.; Ho, Cheng-Ying; Korhonen, Essi M. New England Journal of Medicine, Vol. 374, Issue 22 https://doi.org/10.1056/NEJMoa1601824	journal	June 2016
Zika Virus Infection in Pregnant Women in Rio de Janeiro Brasil, Patrícia; Pereira, José P.; Moreira, M. Elisabeth New England Journal of Medicine, Vol. 375, Issue 24 https://doi.org/10.1056/NEJMoa1602412	journal	December 2016
Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection Frost, S. D. W.; Wrin, T.; Smith, D. M. Proceedings of the National Academy of Sciences, Vol. 102, Issue 51 https://doi.org/10.1073/pnas.0504658102	journal	December 2005
Arbovirus high fidelity variant loses fitness in mosquitoes and mice Coffey, L. L.; Beeharry, Y.; Borderia, A. V. Proceedings of the National Academy of Sciences, Vol. 108, Issue 38 https://doi.org/10.1073/pnas.1111650108	journal	September 2011
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission Shan, Chao; Xia, Hongjie; Haller, Sherry L. Proceedings of the National Academy of Sciences, Vol. 117, Issue 33 https://doi.org/10.1073/pnas.2005722117	journal	August 2020
Maternal-Fetal Transmission of Zika Virus: Routes and Signals for Infection Cao, Bin; Diamond, Michael S.; Mysorekar, Indira U. Journal of Interferon & Cytokine Research, Vol. 37, Issue 7 https://doi.org/10.1089/jir.2017.0011	journal	July 2017
A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data Li, H. Bioinformatics, Vol. 27, Issue 21 https://doi.org/10.1093/bioinformatics/btr509	journal	September 2011
Prolonged Detection of Zika Virus RNA in Pregnant Women Meaney-Delman, Dana; Oduyebo, Titilope; Polen, Kara N. D. Obstetrics & Gynecology, Vol. 128, Issue 4 https://doi.org/10.1097/AOG.0000000000001625	journal	January 2016
Zika infection and the development of neurological defects Russo, Fabiele Baldino; Jungmann, Patricia; Beltrão-Braga, Patricia Cristina Baleeiro Cellular Microbiology, Vol. 19, Issue 6 https://doi.org/10.1111/cmi.12744	journal	May 2017
A single mutation in the prM protein of Zika virus contributes to fetal microcephaly Yuan, Ling; Huang, Xing-Yao; Liu, Zhong-Yu Science, Vol. 358, Issue 6365 https://doi.org/10.1126/science.aam7120	journal	September 2017
DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes Van Rompay, Koen K. A.; Keesler, Rebekah I.; Ardeshir, Amir Science Translational Medicine, Vol. 11, Issue 523 https://doi.org/10.1126/scitranslmed.aay2736	journal	December 2019
Intercompartmental Recombination of HIV-1 Contributes to env Intrahost Diversity and Modulates Viral Tropism and Sensitivity to Entry Inhibitors Brown, R. J. P.; Peters, P. J.; Caron, C. Journal of Virology, Vol. 85, Issue 12 https://doi.org/10.1128/JVI.00131-11	journal	April 2011
Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus Li, Xiao-Dan; Deng, Cheng-Lin; Ye, Han-Qing Journal of Virology, Vol. 90, Issue 12 https://doi.org/10.1128/JVI.00340-16	journal	June 2016
Chimeric GII.4 Norovirus Virus-Like-Particle-Based Vaccines Induce Broadly Blocking Immune Responses Debbink, K.; Lindesmith, L. C.; Donaldson, E. F. Journal of Virology, Vol. 88, Issue 13 https://doi.org/10.1128/JVI.00785-14	journal	April 2014
Combination of Immune and Viral Factors Distinguishes Low-Risk versus High-Risk HIV-1 Disease Progression in HLA-B*5701 Subjects Norström, Melissa M.; Buggert, Marcus; Tauriainen, Johanna Journal of Virology, Vol. 86, Issue 18 https://doi.org/10.1128/JVI.01165-12	journal	July 2012
Chikungunya Virus Fidelity Variants Exhibit Differential Attenuation and Population Diversity in Cell Culture and Adult Mice Riemersma, Kasen K.; Steiner, Cody; Singapuri, Anil Journal of Virology, Vol. 93, Issue 3 https://doi.org/10.1128/JVI.01606-18	journal	February 2019
Virus and Host Factors Affecting the Clinical Outcome of Bluetongue Virus Infection Caporale, M.; Di Gialleonorado, L.; Janowicz, A. Journal of Virology, Vol. 88, Issue 18 https://doi.org/10.1128/JVI.01641-14	journal	July 2014
Mutagenesis of the yellow fever virus NS2B protein: effects on proteolytic processing, NS2B-NS3 complex formation, and viral replication Chambers, T. J.; Nestorowicz, A.; Amberg, S. M. Journal of Virology, Vol. 67, Issue 11 https://doi.org/10.1128/JVI.67.11.6797-6807.1993	journal	November 1993
A Full-Length Infectious cDNA Clone of Zika Virus from the 2015 Epidemic in Brazil as a Genetic Platform for Studies of Virus-Host Interactions and Vaccine Development Tsetsarkin, Konstantin A.; Kenney, Heather; Chen, Rubing mBio, Vol. 7, Issue 4 https://doi.org/10.1128/mBio.01114-16	journal	August 2016
Congenital Brain Abnormalities and Zika Virus: What the Radiologist Can Expect to See Prenatally and Postnatally Soares de Oliveira-Szejnfeld, Patricia; Levine, Deborah; Melo, Adriana Suely de Oliveira Radiology, Vol. 281, Issue 1 https://doi.org/10.1148/radiol.2016161584	journal	October 2016
Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses Nora, Tamara; Bouchonnet, Francine; Labrosse, Béatrice Retrovirology, Vol. 5, Issue 1 https://doi.org/10.1186/1742-4690-5-23	journal	February 2008
An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar Grubaugh, Nathan D.; Gangavarapu, Karthik; Quick, Joshua Genome Biology, Vol. 20, Issue 1 https://doi.org/10.1186/s13059-018-1618-7	journal	January 2019
Zika Virus Infection as a Cause of Congenital Brain Abnormalities and Guillain–Barré Syndrome: Systematic Review Krauer, Fabienne; Riesen, Maurane; Reveiz, Ludovic PLOS Medicine, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pmed.1002203	journal	January 2017
Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise Sarno, Manoel; Sacramento, Gielson A.; Khouri, Ricardo PLOS Neglected Tropical Diseases, Vol. 10, Issue 2 https://doi.org/10.1371/journal.pntd.0004517	journal	February 2016
Vector Competence of American Mosquitoes for Three Strains of Zika Virus Weger-Lucarelli, James; Rückert, Claudia; Chotiwan, Nunya PLOS Neglected Tropical Diseases, Vol. 10, Issue 10 https://doi.org/10.1371/journal.pntd.0005101	journal	October 2016
Zika viruses of African and Asian lineages cause fetal harm in a mouse model of vertical transmission Jaeger, Anna S.; Murrieta, Reyes A.; Goren, Lea R. PLOS Neglected Tropical Diseases, Vol. 13, Issue 4 https://doi.org/10.1371/journal.pntd.0007343	journal	April 2019
Chikungunya virus populations experience diversity- dependent attenuation and purifying intra-vector selection in Californian Aedes aegypti mosquitoes Riemersma, Kasen K.; Coffey, Lark L. PLOS Neglected Tropical Diseases, Vol. 13, Issue 11 https://doi.org/10.1371/journal.pntd.0007853	journal	November 2019
The Role of Viral Population Diversity in Adaptation of Bovine Coronavirus to New Host Environments Borucki, Monica K.; Allen, Jonathan E.; Chen-Harris, Haiyin PLoS ONE, Vol. 8, Issue 1 https://doi.org/10.1371/journal.pone.0052752	journal	January 2013
Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques Coffey, Lark L.; Pesavento, Patricia A.; Keesler, Rebekah I. PLOS ONE, Vol. 12, Issue 1 https://doi.org/10.1371/journal.pone.0171148	journal	January 2017
Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection Mohr, Emma L.; Block, Lindsey N.; Newman, Christina M. PLOS ONE, Vol. 13, Issue 1 https://doi.org/10.1371/journal.pone.0190617	journal	January 2018
Multiscale analysis for patterns of Zika virus genotype emergence, spread, and consequence Borucki, Monica K.; Collette, Nicole M.; Coffey, Lark L. PLOS ONE, Vol. 14, Issue 12 https://doi.org/10.1371/journal.pone.0225699	journal	December 2019
Alphavirus Mutator Variants Present Host-Specific Defects and Attenuation in Mammalian and Insect Models Rozen-Gagnon, Kathryn; Stapleford, Kenneth A.; Mongelli, Vanesa PLoS Pathogens, Vol. 10, Issue 1 https://doi.org/10.1371/journal.ppat.1003877	journal	January 2014
Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues Hirsch, Alec J.; Smith, Jessica L.; Haese, Nicole N. PLOS Pathogens, Vol. 13, Issue 4 https://doi.org/10.1371/journal.ppat.1006317	journal	April 2017
Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques Nguyen, Sydney M.; Antony, Kathleen M.; Dudley, Dawn M. PLOS Pathogens, Vol. 13, Issue 5 https://doi.org/10.1371/journal.ppat.1006378	journal	May 2017
Zika virus damages the human placental barrier and presents marked fetal neurotropism Noronha, Lucia de; Zanluca, Camila; Azevedo, Marina Luize Viola Memórias do Instituto Oswaldo Cruz, Vol. 111, Issue 5 https://doi.org/10.1590/0074-02760160085	journal	April 2016
Defining the syndrome associated with congenital Zika virus infection Costello, Anthony; Dua, Tarun; Duran, Pablo Bulletin of the World Health Organization, Vol. 94, Issue 6 https://doi.org/10.2471/BLT.16.176990	journal	June 2016
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007 Lanciotti, Robert S.; Kosoy, Olga L.; Laven, Janeen J. Emerging Infectious Diseases, Vol. 14, Issue 8 https://doi.org/10.3201/eid1408.080287	journal	August 2008
Zika Virus Outside Africa Hayes, Edward B. Emerging Infectious Diseases, Vol. 15, Issue 9 https://doi.org/10.3201/eid1509.090442	journal	September 2009
Development of a Zika Virus Infection Model in Cynomolgus Macaques Koide, Fusataka; Goebel, Scott; Snyder, Beth Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.02028	journal	December 2016

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Two Sides of a Coin: a Zika Virus Mutation Selected in Pregnant Rhesus Macaques Promotes Fetal Infection in Mice but at a Cost of Reduced Fitness in Nonpregnant Macaques and Diminished Transmissibility by Vectors

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