Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets

Williams, Paul T.

doi:10.7717/peerj.10914

Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets

Journal Article · Tue Feb 16 00:00:00 EST 2021 · PeerJ

DOI:https://doi.org/10.7717/peerj.10914· OSTI ID:1815952

^[1]

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Molecular Biophysics & Integrated Bioimaging Division; OSTI

“Quantile-dependent expressivity” occurs when the effect size of a genetic variant depends upon whether the phenotype (e.g., C-reactive protein, CRP) is high or low relative to its distribution. We have previously shown that the heritabilities (h²) of coffee and alcohol consumption, postprandial lipemia, lipoproteins, leptin, adiponectin, adiposity, and pulmonary function are quantile-specific. Whether CRP heritability is quantile-specific is currently unknown.

Methods

Serum CRP concentrations from 2,036 sibships and 6,144 offspring-parent pairs were analyzed from the Framingham Heart Study. Quantile-specific heritability from full-sib (β_FS,h²={(1 + 8r_spouseβ_FS)^0.5- 1}/(2r_spouse)) and offspring-parent regression slopes (β_OP,h²= 2β_OP/(1 + r_spouse)) were estimated robustly by quantile regression with nonparametric significance determined from 1,000 bootstrap samples.

Results

Quantile-specifich²(±SE) increased with increasing percentiles of the offspring’s age- and sex-adjusted CRP distribution when estimated from β_OP(P_trend= 0.0004): 0.02 ± 0.01 at the 10th, 0.04 ± 0.01 at the 25th, 0.10 ± 0.02 at the 50th, 0.20 ± 0.05 at the 75th, and 0.33 ± 0.10 at the 90th percentile, and when estimated from β_FS(P_trend= 0.0008): 0.03±0.01 at the 10th, 0.06 ± 0.02 at the 25th, 0.14 ± 0.03 at the 50th, 0.24 ± 0.05 at the 75th, and 0.53 ± 0.21 at the 90th percentile.

Conclusion

Heritability of serum CRP concentration is quantile-specific, which may explain or contribute to the inflated CRP differences betweenCRP(rs1130864, rs1205, rs1800947, rs2794521, rs3091244),FGB(rs1800787),IL-6(rs1800795, rs1800796),IL6R(rs8192284),TNF-α (rs1800629) andAPOEgenotypes following CABG surgery, stroke, TIA, curative esophagectomy, intensive periodontal therapy, or acute exercise; during acute coronary syndrome orStaphylococcus aureusbacteremia; or in patients with chronic rheumatoid arthritis, diabetes, peripheral arterial disease, ankylosing spondylitis, obesity or inflammatory bowel disease or who smoke.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1815952

Journal Information:: PeerJ, Journal Name: PeerJ Vol. 9; ISSN 2167-8359

Publisher:: PeerJ Inc.Copyright Statement

Country of Publication:: United States

Language:: English

References (93)

The Effect of Weight Loss on C-Reactive Protein: A Systematic Review Selvin, Elizabeth Archives of Internal Medicine, Vol. 167, Issue 1 https://doi.org/10.1001/archinte.167.1.31	journal	January 2007
Elevated C-Reactive Protein Levels in Overweight and Obese Adults Visser, Marjolein JAMA, Vol. 282, Issue 22 https://doi.org/10.1001/jama.282.22.2131	journal	December 1999
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus Pradhan, Aruna D. JAMA, Vol. 286, Issue 3 https://doi.org/10.1001/jama.286.3.327	journal	July 2001
Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome: A Randomized Trial Esposito, Katherine; Marfella, Raffaele; Ciotola, Miryam JAMA, Vol. 292, Issue 12 https://doi.org/10.1001/jama.292.12.1440	journal	September 2004
Association between C‐reactive protein gene variant and treatment efficacy of etanercept in ankylosing spondylitis patients receiving hip arthroplasty Xu, Yuansheng; Jiang, Wei; Zhang, Hui Journal of Clinical Laboratory Analysis, Vol. 34, Issue 8 https://doi.org/10.1002/jcla.23343	journal	April 2020
Chronic consumption of a low-fat diet improves cardiometabolic risk factors according to the CLOCK gene in patients with coronary heart disease Gomez-Delgado, Francisco; Garcia-Rios, Antonio; Alcala-Diaz, Juan Francisco Molecular Nutrition & Food Research, Vol. 59, Issue 12 https://doi.org/10.1002/mnfr.201500375	journal	October 2015
Obesity-susceptibility loci and the tails of the pediatric BMI distribution: Obesity Loci and the Pediatric BMI Distribution Mitchell, Jonathan A.; Hakonarson, Hakon; Rebbeck, Timothy R. Obesity, Vol. 21, Issue 6 https://doi.org/10.1002/oby.20319	journal	June 2013
Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment Wielińska, Joanna; Kolossa, Katarzyna; Świerkot, Jerzy Archivum Immunologiae et Therapiae Experimentalis, Vol. 68, Issue 4 https://doi.org/10.1007/s00005-020-00590-6	journal	August 2020
Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level Szalai, A. J.; Wu, J.; Lange, E. M. Journal of Molecular Medicine, Vol. 83, Issue 6 https://doi.org/10.1007/s00109-005-0658-0	journal	March 2005
An immune origin of type 2 diabetes? Kolb, H.; Mandrup-Poulsen, T. Diabetologia, Vol. 48, Issue 6 https://doi.org/10.1007/s00125-005-1764-9	journal	April 2005
Common Variants in the CRP Promoter are Associated with a High C-Reactive Protein Level in Kawasaki Disease Kim, Jae-Jung; Yun, Sin Weon; Yu, Jeong Jin Pediatric Cardiology, Vol. 36, Issue 2 https://doi.org/10.1007/s00246-014-1032-1	journal	September 2014
Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease Vatay, �gnes; Bene, L�szl�; Kov�cs, �gota Immunogenetics, Vol. 55, Issue 4 https://doi.org/10.1007/s00251-003-0575-8	journal	July 2003
Human C-reactive protein (CRP) 1059G/C polymorphism Cao, Henian; Hegele, Robert A. Journal of Human Genetics, Vol. 45, Issue 2 https://doi.org/10.1007/s100380050022	journal	March 2000
Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia Mölkänen, T.; Rostila, A.; Ruotsalainen, E. European Journal of Clinical Microbiology & Infectious Diseases, Vol. 29, Issue 9 https://doi.org/10.1007/s10096-010-0978-z	journal	June 2010
Quantile-Specific Heritability may Account for Gene–Environment Interactions Involving Coffee Consumption Williams, Paul T. Behavior Genetics, Vol. 50, Issue 2 https://doi.org/10.1007/s10519-019-09989-0	journal	January 2020
Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients Williams, Paul T. Behavior Genetics, Vol. 50, Issue 5 https://doi.org/10.1007/s10519-020-10005-z	journal	July 2020
Endogenous estradiol and inflammation biomarkers: potential interacting mechanisms of obesity-related disease Eldridge, Ronald C.; Wentzensen, Nicolas; Pfeiffer, Ruth M. Cancer Causes & Control, Vol. 31, Issue 4 https://doi.org/10.1007/s10552-020-01280-6	journal	February 2020
Fibrinogen Beta-Chain -C148T Polymorphism is Associated with Increased Fibrinogen, C-Reactive Protein, and Interleukin-6 in Patients Undergoing Coronary Artery Bypass Grafting Wypasek, Ewa; Stepien, Ewa; Kot, Malgorzata Inflammation, Vol. 35, Issue 2 https://doi.org/10.1007/s10753-011-9332-6	journal	April 2011
Genetic determinants of C-reactive protein Danik, Jacqueline Suk; Ridker, Paul M. Current Atherosclerosis Reports, Vol. 9, Issue 3 https://doi.org/10.1007/s11883-007-0019-2	journal	April 2007
Inflammatory pathways in atherosclerosis and acute coronary syndromes Plutzky, Jorge The American Journal of Cardiology, Vol. 88, Issue 8 https://doi.org/10.1016/S0002-9149(01)01924-5	journal	October 2001
Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein Vickers, M. Cardiovascular Research, Vol. 53, Issue 4 https://doi.org/10.1016/S0008-6363(01)00534-X	journal	March 2002
Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis Zee, Robert Y. L.; Ridker, Paul M. Atherosclerosis, Vol. 162, Issue 1 https://doi.org/10.1016/S0021-9150(01)00703-1	journal	May 2002
A twin study of C-Reactive Protein compared to other risk factors for coronary heart disease Retterstol, Lars; Eikvar, Lars; Berg, Kåre Atherosclerosis, Vol. 169, Issue 2 https://doi.org/10.1016/S0021-9150(03)00192-8	journal	August 2003
Genome-wide Association and Population Genetic Analysis of C-Reactive Protein in African American and Hispanic American Women Reiner, Alex P.; Beleza, Sandra; Franceschini, Nora The American Journal of Human Genetics, Vol. 91, Issue 3 https://doi.org/10.1016/j.ajhg.2012.07.023	journal	September 2012
Penetrance of Polygenic Obesity Susceptibility Loci across the Body Mass Index Distribution Abadi, Arkan; Alyass, Akram; Robiou du Pont, Sebastien The American Journal of Human Genetics, Vol. 101, Issue 6 https://doi.org/10.1016/j.ajhg.2017.10.007	journal	December 2017
Dose-response association between C-reactive protein and risk of all-cause and cause-specific mortality: a systematic review and meta-analysis of cohort studies Ni, Peng; Yu, Mingyang; Zhang, Rongguang Annals of Epidemiology, Vol. 51 https://doi.org/10.1016/j.annepidem.2020.07.005	journal	November 2020
New and confirmatory evidence of an association between APOE genotype and baseline C-reactive protein in dyslipidemic individuals Judson, Richard; Brain, Carlos; Dain, Brad Atherosclerosis, Vol. 177, Issue 2 https://doi.org/10.1016/j.atherosclerosis.2004.07.012	journal	December 2004
A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein Kovacs, Alexander; Green, Fiona; Hansson, Lars-Olof Atherosclerosis, Vol. 178, Issue 1 https://doi.org/10.1016/j.atherosclerosis.2004.08.018	journal	January 2005
C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus D’Aiuto, Francesco; Casas, Juan P.; Shah, Tina Atherosclerosis, Vol. 179, Issue 2 https://doi.org/10.1016/j.atherosclerosis.2004.10.036	journal	April 2005
Fibrinogen and CRP in Israeli families: Genetic and environmental sources of concentrations and longitudinal changes Friedlander, Yechiel; Kark, Jeremy D.; Sinnreich, Ronit Atherosclerosis, Vol. 189, Issue 1 https://doi.org/10.1016/j.atherosclerosis.2005.11.030	journal	November 2006
Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: Interaction with obesity Teng, Ming-Sheng; Hsu, Lung-An; Wu, Semon Atherosclerosis, Vol. 204, Issue 2 https://doi.org/10.1016/j.atherosclerosis.2008.10.034	journal	June 2009
Genetic and environmental influences on stability and change in baseline levels of C-reactive protein: A longitudinal twin study Sas, Arthur A.; Vaez, Ahmad; Jamshidi, Yalda Atherosclerosis, Vol. 265 https://doi.org/10.1016/j.atherosclerosis.2017.08.008	journal	October 2017
Serum High-Sensitive C-Reactive Protein Level and CRP Genetic Polymorphisms Are Associated with Abdominal Aortic Aneurysm Shangwei, Zuo; Yingqi, Wei; Jiang, Xiong Annals of Vascular Surgery, Vol. 45 https://doi.org/10.1016/j.avsg.2017.05.024	journal	November 2017
Effect of obesity on the association between common variations in the HNF1A gene region and C-reactive protein level in Taiwanese Hsu, Lung-An; Ko, Yu-Lin; Teng, Ming-Sheng Clinica Chimica Acta, Vol. 412, Issue 9-10 https://doi.org/10.1016/j.cca.2010.12.027	journal	April 2011
Effect of obesity on the association between ATF3 gene haplotypes and C-reactive protein level in Taiwanese Wu, Semon; Hsu, Lung-An; Cheng, Ching-Feng Clinica Chimica Acta, Vol. 412, Issue 11-12 https://doi.org/10.1016/j.cca.2011.02.011	journal	May 2011
Influence of the IL-6 −572C>G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men Shin, Kyung-Kyun; Jang, Yangsoo; Koh, Soo Jeong Cytokine, Vol. 39, Issue 2 https://doi.org/10.1016/j.cyto.2007.06.005	journal	August 2007
Low-grade inflammation markers in children and adolescents: Influence of anthropometric characteristics and CRP and IL6 polymorphisms Todendi, P. F.; Possuelo, L. G.; Klinger, E. I. Cytokine, Vol. 88 https://doi.org/10.1016/j.cyto.2016.09.007	journal	December 2016
APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample Hubacek, Jaroslav A.; Peasey, Anne; Pikhart, Hynek Human Immunology, Vol. 71, Issue 3 https://doi.org/10.1016/j.humimm.2010.01.008	journal	March 2010
Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications Williams, Paul T. International Journal of Cardiology, Vol. 327 https://doi.org/10.1016/j.ijcard.2020.11.070	journal	March 2021
Genetic Variants in P-Selectin and C-Reactive Protein Influence Susceptibility to Cognitive Decline After Cardiac Surgery Mathew, Joseph P.; Podgoreanu, Mihai V.; Grocott, Hilary P. Journal of the American College of Cardiology, Vol. 49, Issue 19 https://doi.org/10.1016/j.jacc.2007.01.080	journal	May 2007
C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk Hage, Fadi G.; Szalai, Alexander J. Journal of the American College of Cardiology, Vol. 50, Issue 12 https://doi.org/10.1016/j.jacc.2007.06.012	journal	September 2007
Quantile-specific heritability of high-density lipoproteins with implications for precision medicine Williams, Paul T. Journal of Clinical Lipidology, Vol. 14, Issue 4 https://doi.org/10.1016/j.jacl.2020.05.099	journal	July 2020
C-Reactive Protein 1059G>CGenetic Polymorphism Influences Serum C-Reactive Protein Levels after Esophagectomy in Patients with Thoracic Esophageal Cancer Motoyama, Satoru; Miura, Masatomo; Hinai, Yudai Journal of the American College of Surgeons, Vol. 209, Issue 4 https://doi.org/10.1016/j.jamcollsurg.2009.06.365	journal	October 2009
CRP after 2004 Agrawal, Alok Molecular Immunology, Vol. 42, Issue 8 https://doi.org/10.1016/j.molimm.2004.09.028	journal	May 2005
Apolipoprotein A2 −265 T>C polymorphism interacts with dietary fatty acids intake to modulate inflammation in type 2 diabetes mellitus patients Keramat, Laleh; Sadrzadeh-Yeganeh, Haleh; Sotoudeh, Gity Nutrition, Vol. 37 https://doi.org/10.1016/j.nut.2016.12.012	journal	May 2017
The interaction of adiposity with the CRP gene affects CRP levels: Age, Gene/Environment Susceptibilty-Reykjavik Study Eiriksdottir, G.; Smith, A. V.; Aspelund, T. International Journal of Obesity, Vol. 33, Issue 2 https://doi.org/10.1038/ijo.2008.274	journal	January 2009
A QTL on 12q Influencing an Inflammation Marker and Obesity in White Women: The NHLBI Family Heart Study Wu, Jun; Pankow, James S.; Tracy, Russell P. Obesity, Vol. 17, Issue 3 https://doi.org/10.1038/oby.2008.556	journal	March 2009
Quantile-dependent heritability of computed tomography, dual-energy x-ray absorptiometry, anthropometric, and bioelectrical measures of adiposity Williams, Paul T. International Journal of Obesity, Vol. 44, Issue 10 https://doi.org/10.1038/s41366-020-0636-1	journal	July 2020
Gene-environment interactions due to quantile-specific heritability of triglyceride and VLDL concentrations Williams, Paul T. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-60965-9	journal	March 2020
Quantile-specific heritability of sibling leptin concentrations and its implications for gene-environment interactions Williams, Paul T. Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-79116-1	journal	December 2020
Qualitative and quantitative effects of APOE genetic variation on plasma C-reactive protein, LDL-cholesterol, and apoE protein Chasman, D. I.; Kozlowski, P.; Zee, R. Y. Genes & Immunity, Vol. 7, Issue 3 https://doi.org/10.1038/sj.gene.6364289	journal	March 2006
Relation of C-reactive protein to body fat distribution and features of the metabolic syndrome in Europeans and South Asians Forouhi, Ng; Sattar, N.; McKeigue, Pm International Journal of Obesity, Vol. 25, Issue 9 https://doi.org/10.1038/sj.ijo.0801723	journal	September 2001
Acute-Phase Proteins and Other Systemic Responses to Inflammation Gabay, Cem; Kushner, Irving New England Journal of Medicine, Vol. 340, Issue 6 https://doi.org/10.1056/NEJM199902113400607	journal	February 1999
Sibling and parent--offspring correlation estimation with variable family size. Karlin, S.; Cameron, E. C.; Williams, P. T. Proceedings of the National Academy of Sciences, Vol. 78, Issue 5 https://doi.org/10.1073/pnas.78.5.2664	journal	May 1981
Effects of a polymorphism in the human tumor necrosis factor promoter on transcriptional activation Wilson, A. G.; Symons, J. A.; McDowell, T. L. Proceedings of the National Academy of Sciences, Vol. 94, Issue 7 https://doi.org/10.1073/pnas.94.7.3195	journal	April 1997
Anxiety disorders and CRP in a population cohort study with 54,326 participants: The LifeLines study Naudé, Petrus J. W.; Roest, Annelieke M.; Stein, Dan J. The World Journal of Biological Psychiatry, Vol. 19, Issue 6 https://doi.org/10.1080/15622975.2018.1433325	journal	February 2018
Linkage of Inflammatory Bowel Disease to Human Chromosome 6p Hampe, Jochen; Shaw, Sarah H.; Saiz, Robert The American Journal of Human Genetics, Vol. 65, Issue 6 https://doi.org/10.1086/302677	journal	December 1999
The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination Splansky, G. L.; Corey, D.; Yang, Q. American Journal of Epidemiology, Vol. 165, Issue 11 https://doi.org/10.1093/aje/kwm021	journal	April 2007
An Investigation of Coronary Heart Disease in Families Kannel, William B.; Feinleib, Manning; McNAMARA, Patricia M. American Journal of Epidemiology, Vol. 110, Issue 3 https://doi.org/10.1093/oxfordjournals.aje.a112813	journal	September 1979
Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals Luetragoon, Thitiya; Rutqvist, Lars E.; Tangvarasittichai, Orathai Immunology, Vol. 154, Issue 1 https://doi.org/10.1111/imm.12864	journal	January 2018
The Polymorphisms of C-Reactive Protein Gene Modify the Association Between Central Obesity and Lung Function in Taiwan Asthmatics: C-reactive Protein Gene, Central Obesity and Lung Function Wang, T. -N.; Wu, C. -C.; Huang, M. -S. Scandinavian Journal of Immunology, Vol. 74, Issue 5 https://doi.org/10.1111/j.1365-3083.2011.02599.x	journal	October 2011
Triggered C-reactive protein (CRP) concentrations and the CRP gene −717A>G polymorphism in acute stroke or transient ischemic attack: CRP gene −717A>G polymorphism in acute stroke Ben-Assayag, E.; Shenhar-Tsarfaty, S.; Bova, I. European Journal of Neurology, Vol. 14, Issue 3 https://doi.org/10.1111/j.1468-1331.2006.01661.x	journal	February 2007
Influence of Genetic Variation in the C-Reactive Protein Gene on the Inflammatory Response During and After Acute Coronary Ischemia Suk Danik, J.; Chasman, D. I.; Cannon, C. P. Annals of Human Genetics, Vol. 70, Issue 6 https://doi.org/10.1111/j.1469-1809.2006.00272.x	journal	November 2006
Periodontal therapy: a novel non-drug-induced experimental model to study human inflammation D'Aiuto, F.; Nibali, L.; Mohamed-Ali, V. Journal of Periodontal Research, Vol. 39, Issue 5 https://doi.org/10.1111/j.1600-0765.2004.00741.x	journal	October 2004
Analysis of G(-174)C IL-6 polymorphism and plasma concentrations of inflammatory markers in patients with type 2 diabetes and peripheral arterial disease Libra, M. Journal of Clinical Pathology, Vol. 59, Issue 2 https://doi.org/10.1136/jcp.2004.025452	journal	February 2006
Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol Williams, Paul T. Lifestyle Genomics, Vol. 14, Issue 1 https://doi.org/10.1159/000511421	journal	December 2020
Human CRP Gene Polymorphism Influences CRP Levels: Implications for the Prediction and Pathogenesis of Coronary Heart Disease Brull, D. J.; Serrano, Norma; Zito, F. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 23, Issue 11 https://doi.org/10.1161/01.ATV.0000084640.21712.9C	journal	November 2003
C-Reactive Protein, Fibrin D-Dimer, and Incident Ischemic Heart Disease in the Speedwell Study: Are Inflammation and Fibrin Turnover Linked in Pathogenesis? Lowe, Gordon D. O.; Yarnell, John W. G.; Rumley, Ann Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 21, Issue 4 https://doi.org/10.1161/01.atv.21.4.603	journal	April 2001
Ancestry as a Determinant of Mean Population C-Reactive Protein Values: Implications for Cardiovascular Risk Prediction Shah, Tina; Newcombe, Paul; Smeeth, Liam Circulation: Cardiovascular Genetics, Vol. 3, Issue 5 https://doi.org/10.1161/CIRCGENETICS.110.957431	journal	October 2010
Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels Dehghan, Abbas; Dupuis, Josée; Barbalic, Maja Circulation, Vol. 123, Issue 7 https://doi.org/10.1161/CIRCULATIONAHA.110.948570	journal	February 2011
C-reactive protein: a critical update Pepys, Mark B.; Hirschfield, Gideon M. Journal of Clinical Investigation, Vol. 111, Issue 12 https://doi.org/10.1172/JCI200318921	journal	June 2003
Effect of the G-308A polymorphism of the tumor necrosis factor (TNF)-α gene promoter site on plasma levels of TNF-α and C-reactive protein in smokers: a cross-sectional study Gander, Marie-Louise; Fischer, Joachim E.; Maly, Friedrich E. BMC Cardiovascular Disorders, Vol. 4, Issue 1 https://doi.org/10.1186/1471-2261-4-17	journal	October 2004
C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery Perry, Tjörvi E.; Muehlschlegel, Jochen D.; Liu, Kuang-Yu BMC Medical Genetics, Vol. 10, Issue 1 https://doi.org/10.1186/1471-2350-10-38	journal	May 2009
Socioeconomic and racial/ethnic differentials of C-reactive protein levels: a systematic review of population-based studies Nazmi, Aydin; Victora, Cesar G. BMC Public Health, Vol. 7, Issue 1 https://doi.org/10.1186/1471-2458-7-212	journal	August 2007
APOE – a genetic marker of comorbidity in subjects with morbid obesity Farup, Per G.; Rootwelt, Helge; Hestad, Knut BMC Medical Genetics, Vol. 21, Issue 1 https://doi.org/10.1186/s12881-020-01082-2	journal	July 2020
CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients Ammitzbøll, Christian Gytz; Steffensen, Rudi; Bøgsted, Martin Arthritis Research & Therapy, Vol. 16, Issue 5 https://doi.org/10.1186/s13075-014-0475-3	journal	October 2014
Two Promoter Polymorphisms Regulating Interleukin-6 Gene Expression Are Associated with Circulating Levels of C-Reactive Protein and Markers of Bone Resorption in Postmenopausal Women Ferrari, S. L.; Ahn-Luong, L.; Garnero, P. The Journal of Clinical Endocrinology & Metabolism, Vol. 88, Issue 1 https://doi.org/10.1210/jc.2002-020092	journal	January 2003
Inflammatory markers and cognition in well-functioning African-American and white elders Yaffe, K.; Lindquist, K.; Penninx, B. W. Neurology, Vol. 61, Issue 1 https://doi.org/10.1212/01.WNL.0000073620.42047.D7	journal	July 2003
Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study Shoamanesh, A.; Preis, S. R.; Beiser, A. S. Neurology, Vol. 84, Issue 8 https://doi.org/10.1212/WNL.0000000000001279	journal	January 2015
Quantile Regression Koenker, Roger; Hallock, Kevin F. Journal of Economic Perspectives, Vol. 15, Issue 4 https://doi.org/10.1257/jep.15.4.143	journal	November 2001
The increased plasma C-reactive protein and interleukin-6 levels in patients undergoing coronary artery bypass grafting surgery are associated with the interleukin-6−174G > C gene polymorphism Wypasek, E.; Undas, A.; Sniezek-Maciejewska, M. Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, Vol. 47, Issue 4 https://doi.org/10.1258/acb.2010.090305	journal	June 2010
A Genetic Association Study of Serum Acute-Phase C-Reactive Protein Levels in Rheumatoid Arthritis: Implications for Clinical Interpretation Rhodes, Benjamin; Merriman, Marilyn E.; Harrison, Andrew PLoS Medicine, Vol. 7, Issue 9 https://doi.org/10.1371/journal.pmed.1000341	journal	September 2010
Genetic Markers of Obesity Risk: Stronger Associations with Body Composition in Overweight Compared to Normal-Weight Children Beyerlein, Andreas; von Kries, Rüdiger; Ness, Andrew R. PLoS ONE, Vol. 6, Issue 4 https://doi.org/10.1371/journal.pone.0019057	journal	April 2011
Increased Genetic Variance of BMI with a Higher Prevalence of Obesity Rokholm, Benjamin; Silventoinen, Karri; Ängquist, Lars PLoS ONE, Vol. 6, Issue 6 https://doi.org/10.1371/journal.pone.0020816	journal	June 2011
Quantile-Specific Penetrance of Genes Affecting Lipoproteins, Adiposity and Height Williams, Paul T. PLoS ONE, Vol. 7, Issue 1 https://doi.org/10.1371/journal.pone.0028764	journal	January 2012
Quantile-dependent expressivity of postprandial lipemia Williams, Paul T. PLOS ONE, Vol. 15, Issue 2 https://doi.org/10.1371/journal.pone.0229495	journal	February 2020
Interleukin-6 Receptor Gene Variations, Plasma Interleukin-6 Levels, and Type 2 Diabetes in U.S. Women Qi, L.; Rifai, N.; Hu, F. B. Diabetes, Vol. 56, Issue 12 https://doi.org/10.2337/db07-0505	journal	September 2007
Elevated Serum C-Reactive Protein Concentration in Bosnian Patients with Probable Alzheimer's Disease Zaciragic, Asija; Lepara, Orhan; Valjevac, Amina Journal of Alzheimer's Disease, Vol. 12, Issue 2 https://doi.org/10.3233/JAD-2007-12204	journal	September 2007
C-Reactive Protein and High-Sensitivity C-Reactive Protein: An Update for Clinicians Windgassen, Elizabeth B.; Funtowicz, Luciana; Lunsford, Tisha N. Postgraduate Medicine, Vol. 123, Issue 1 https://doi.org/10.3810/pgm.2011.01.2252	journal	January 2011
APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults Carvalho-Wells, Andrew L.; Jackson, Kim G.; Lockyer, Stacey The American Journal of Clinical Nutrition, Vol. 96, Issue 6 https://doi.org/10.3945/ajcn.112.043240	journal	November 2012
Polymorphisms of tumor necrosis factor-alpha and interleukin-6 gene and C-reactive protein profiles in patients with idiopathic dilated cardiomyopathy Liaquat, Afrose; Asifa, Gul Zareen; Zeenat, Asyia Annals of Saudi Medicine, Vol. 34, Issue 5 https://doi.org/10.5144/0256-4947.2014.407	journal	September 2014
Quantile-dependent expressivity of plasma adiponectin concentrations may explain its sex-specific heritability, gene-environment interactions, and genotype-specific response to postprandial lipemia Williams, Paul T. PeerJ, Vol. 8 https://doi.org/10.7717/peerj.10099	journal	January 2020
Spirometric traits show quantile-dependent heritability, which may contribute to their gene-environment interactions with smoking and pollution Williams, Paul T. PeerJ, Vol. 8 https://doi.org/10.7717/peerj.9145	journal	January 2020

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