Biocompatibility of a novel heat-treated and ceramic-coated magnesium alloy (Mg–1.2Zn–0.5Ca–0.5Mn) for resorbable skeletal fixation devices

Chmielewska, Agnieszka; MacDonald, Taylor; Ibrahim, Hamdy; McManus, Tim; Lammel Lindemann, Jan; Smith, Patrick; Rong, Lihan; Luo, Alan; Advincula, Rigoberto; Swieszkowski, Wojciech; Elahinia, Mohammad; Dean, David

doi:10.1557/mrc.2020.46

Title: Biocompatibility of a novel heat-treated and ceramic-coated magnesium alloy (Mg–1.2Zn–0.5Ca–0.5Mn) for resorbable skeletal fixation devices

Journal Article · Thu Dec 24 00:00:00 EST 2020 · MRS Communications

DOI:https://doi.org/10.1557/mrc.2020.46· OSTI ID:1811384

Chmielewska, Agnieszka ^[1]; MacDonald, Taylor ^[2]; Ibrahim, Hamdy ^[3]; McManus, Tim ^[2]; Lammel Lindemann, Jan ^[4]; Smith, Patrick ^[2]; Rong, Lihan ^[5]; Luo, Alan ^[6]; Advincula, Rigoberto ^[7]; Swieszkowski, Wojciech ^[8]; Elahinia, Mohammad ^[9]; Dean, David ^[10]

The Ohio State Univ., Columbus, OH (United States). Dept. of Plastic and Reconstructive Surgery; Warsaw Univ. of Technology (Poland). Materials Science and Engineering
The Ohio State Univ., Columbus, OH (United States). Dept. of Plastic and Reconstructive Surgery
Univ. of Tennessee, Chattanooga, TN (United States). Dept. of Mechanical Engineering
The Ohio State Univ., Columbus, OH (United States). Dept. of Plastic and Reconstructive Surgery; Escuela de Ingenieria y Ciencias, Tecnologico de Monterrey, NL (Mexico); Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca, NL (Mexico)
Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Macromolecular Science and Engineering
The Ohio State Univ., Columbus, OH (United States). Dept. of Materials Science and Engineering
Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Macromolecular Science and Engineering; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Warsaw Univ. of Technology (Poland). Materials Science and Engineering
Univ. of Toledo, OH (United States). Dept. of Mechanical, Industrial and Manufacturing Engineering
The Ohio State Univ., Columbus, OH (United States). Dept. of Plastic and Reconstructive Surgery; The Ohio State Univ., Columbus, OH (United States). Dept. of Materials Science and Engineering

Our recent exploration into the use of biodegradable metals and surface treatments resulting in sufficient strength for skeletal reconstruction applications has led to the need to test these devices’ cytotoxicity. More specifically, our group has developed a resorbable magnesium alloy, Mg–1.2Zn–0.5Ca–0.5Mn, that can be strengthened by heat treatment and coated with a ceramic layer offering time-certain resorption of a medical device. This in vitro study shows that these treatments do not result in cytotoxicity. Both heat-treated (HT) and HT + ceramic-coated (sol–gel) coupons demonstrated more than 70% viability. Thus, these processing steps are likely to be useful in producing biocompatible, resorbable implants that incorporate our Mg–1.2Zn–0.5Ca–0.5Mn alloy.

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1811384

Journal Information:: MRS Communications, Vol. 10, Issue 3; ISSN 2159-6859

Publisher:: Materials Research Society - Cambridge University PressCopyright Statement

Country of Publication:: United States

Language:: English

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