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An orally available non-nucleotide STING agonist with antitumor activity

Journal Article · · Science

Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1810148
Journal Information:
Science, Journal Name: Science Vol. 369
Country of Publication:
United States
Language:
ENGLISH

References (36)

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity journal December 2018
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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity journal May 2015
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression journal July 2017
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Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies journal March 2018
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5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential journal November 2012
Overview of the CCP 4 suite and current developments journal March 2011
Design of amidobenzimidazole STING receptor agonists with systemic activity journal November 2018
Emerging Opportunities and Challenges in Cancer Immunotherapy journal April 2016
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase journal May 2013
Anticancer Flavonoids Are Mouse-Selective STING Agonists journal May 2013
Passive drug permeation through membranes and cellular distribution journal March 2017
Structural basis of STING binding with and phosphorylation by TBK1 journal March 2019
Affinity selection-mass spectrometry screening techniques for small molecule drug discovery journal October 2007
Pharmacological Modulation of the STING Pathway for Cancer Immunotherapy journal May 2019
Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model journal January 2016
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid journal April 2013
Mapping the IκB Kinase β (IKKβ)-binding Interface of the B14 Protein, a Vaccinia Virus Inhibitor of IKKβ-mediated Activation of Nuclear Factor κB journal April 2011
The N -Ethyl- N -Nitrosourea-Induced Goldenticket Mouse Mutant Reveals an Essential Function of Sting in the In Vivo Interferon Response to Listeria monocytogenes and Cyclic Dinucleotides journal November 2010
Roles of the cGAS-STING Pathway in Cancer Immunosurveillance and Immunotherapy journal March 2019
Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists journal January 2019
Very Fast Two-Dimensional NMR Spectroscopy for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of Seconds journal June 2005
Acidity Generated by the Tumor Microenvironment Drives Local Invasion journal January 2013
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids journal May 2007
Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides journal October 2013
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP journal March 2019
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING journal July 2013
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA journal August 2013
Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER journal March 2012

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