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Title: Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization

Journal Article · · J. Med. Chem.
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
DOE - Office Of Science; INDUSTRY
OSTI ID:
1863031
Journal Information:
J. Med. Chem., Vol. 65, Issue (4)
Country of Publication:
United States
Language:
ENGLISH

References (33)

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation journal October 2008
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling journal August 2008
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING journal May 2013
STING is a direct innate immune sensor of cyclic di-GMP journal September 2011
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP journal August 2011
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity journal September 2009
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors journal November 2014
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors journal November 2014
Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis journal January 2016
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity journal May 2015
Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response journal January 2016
Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma journal October 2015
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity journal November 2015
STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment journal October 2014
STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice journal May 2015
STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade journal April 2015
STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer journal July 2018
Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors journal November 2015
Can innate immune system targets turn up the heat on 'cold' tumours? journal December 2017
Diverse roles of STING-dependent signaling on the development of cancer journal February 2015
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid journal April 2013
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA journal August 2013
Design of amidobenzimidazole STING receptor agonists with systemic activity journal November 2018
An orally available non-nucleotide STING agonist with antitumor activity journal August 2020
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic journal August 2020
Dynamic Structural Differences between Human and Mouse STING Lead to Differing Sensitivity to DMXAA journal January 2018
Anticancer Flavonoids Are Mouse-Selective STING Agonists journal May 2013
Single Mutations Reshape the Structural Correlation Network of the DMXAA–Human STING Complex journal February 2017
Finding the sweet spot: the role of nature and nurture in medicinal chemistry journal April 2012
Design of Ester Prodrugs to Enhance Oral Absorption of Poorly Permeable Compounds: Challenges to the Discovery Scientist journal December 2003
Structure Property Relationships of Carboxylic Acid Isosteres journal March 2016
Induction of pro-inflammatory cytokines by 29-kDa FN-f via cGAS/STING pathway journal May 2019
Type I interferon-dependent CCL4 is induced by a cGAS/STING pathway that bypasses viral inhibition and protects infected tissue, independent of viral burden journal October 2019

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