Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Molecular understanding of heteronuclear active sites in heme–copper oxidases, nitric oxide reductases, and sulfite reductases through biomimetic modelling

Journal Article · · Chemical Society Reviews
DOI:https://doi.org/10.1039/d0cs01297a· OSTI ID:1807581
 [1];  [2];  [2];  [2]
  1. Univ. of Illinois at Urbana-Champaign, IL (United States); University of Illinois
  2. Univ. of Illinois at Urbana-Champaign, IL (United States)
+ Show Author Affiliations
Heme-copper oxidases (HCO), nitric oxide reductases (NOR), and sulfite reductases (SiR) catalyze the multi-electron and multi-proton reductions of O2, NO, and SO32-, respectively. Each of these reactions is important to drive cellular energy production through respiratory metabolism and HCO, NOR, and SiR evolved to contain heteronuclear active sites containing heme/copper, heme/nonheme iron, and heme-[4Fe-4S] centers, respectively. The complexity of the structures and reactions of these native enzymes, along with their large sizes and/or membrane associations, make it challenging to fully understand the crucial structural features responsible for the catalytic properties of these active sites. Here, we summarize progress that has been made to better understand these heteronuclear metalloenzymes at the molecular level though study of the native enzymes along with insights gained from biomimetic models comprising either small molecules or proteins. Further understanding the reaction selectivity of these enzymes is discussed through comparisons of their similar heteronuclear active sites, and we offer outlook for further investigations and areas of ongoing study.
Research Organization:
Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0018420
OSTI ID:
1807581
Alternate ID(s):
OSTI ID: 1761247
Journal Information:
Chemical Society Reviews, Journal Name: Chemical Society Reviews Journal Issue: 4 Vol. 50; ISSN 0306-0012
Publisher:
Royal Society of ChemistryCopyright Statement
Country of Publication:
United States
Language:
English

References (374)

Application of 3-Quinolinoyl Picket Porphyrins to the Electroreduction of Dioxygen to Water: Mimicking the Active Site of Cytochromec Oxidase journal February 2001
Electrocatalytic O2 Reduction by Synthetic Analogues of the Heme/Cu Site of Cytochrome Oxidase Incorporated in a Lipid Film journal September 2002
Insights into the mechanism of nitric oxide reductase from a Fe B ‐depleted variant journal May 2019
EPR spectroscopy of putative enzyme intermediates in the NO reductase and the auto‐nitrosylation reaction of Desulfovibrio vulgaris hybrid cluster protein journal July 2019
Oxoiron Porphyrin Species with High-Valent Iron: Formation by Solvent-Dependent Protonation of a Peroxoiron(III) Porphyrinate Derivative journal December 1989
Isolation and Crystal Structure of a Peroxo-Bridged Heme–Copper Complex journal June 2003
A Functional Model of the Cytochromec Oxidase Active Site: Unique Conversion of a Heme-?-peroxo-CuII Intermediate into Heme- superoxo/CuI journal March 2005
Spectroscopic Elucidation of a New Heme/Copper Dioxygen Structure Type: Implications for O⋅⋅⋅O Bond Rupture in Cytochrome c Oxidase journal November 2011
Significant Increase of Oxidase Activity through the Genetic Incorporation of a Tyrosine-Histidine Cross-Link in a Myoglobin Model of Heme-Copper Oxidase journal March 2012
A Designed Functional Metalloenzyme that Reduces O2 to H2O with Over One Thousand Turnovers journal April 2012
Spectroscopic and Computational Study of a Nonheme Iron Nitrosyl Center in a Biosynthetic Model of Nitric Oxide Reductase journal January 2014
Insights Into How Heme Reduction Potentials Modulate Enzymatic Activities of a Myoglobin-based Functional Oxidase journal May 2017
Catalysis and Electron Transfer in De Novo Designed Helical Scaffolds journal March 2020
Not Limited to Iron: A Cobalt Heme–NO Model Facilitates N–N Coupling with External NO in the Presence of a Lewis Acid to Generate N 2 O journal October 2019
X-Ray Crystal Structure of a Mutant Assimilatory Nitrite Reductase That Shows Sulfite Reductase-Like Activity journal September 2012
New Insights into the Nature of Observable Reaction Intermediates in Cytochrome P450 NO Reductase by Using a Combination of Spectroscopy and Quantum Mechanics/Molecular Mechanics Calculations journal January 2014
The Reaction Mechanism of Cytochrome P450 NO Reductase: A Detailed Quantum Mechanics/Molecular Mechanics Study journal November 2011
Connecting [4Fe-4S] Clusters and Hemes - Towards Modeling the Active Site of Sulfite Reductase journal June 2013
Synthesis and Studies of a Super-Structured Porphyrin Derivative - A Potential Building Block for C c O Mimic Models journal March 2009
Catalytic Reduction of Bisulfite by Myoglobin/Surfactant Films journal August 2017
Using Biosynthetic Models of Heme-Copper Oxidase and Nitric Oxide Reductase in Myoglobin to Elucidate Structural Features Responsible for Enzymatic Activities journal September 2016
Dynamics of the K B Proton Pathway in Cytochrome ba 3 from Thermus thermophilus journal January 2017
Crystal structures of nitric oxide reductases provide key insights into functional conversion of respiratory enzymes journal February 2013
Electronic structure of iron(II)-porphyrin nitroxyl complexes: Molecular mechanism of fungal nitric oxide reductase (P450nor) journal September 2006
Improved free energy profile for reduction of NO in cytochrome c dependent nitric oxide reductase (cNOR): FULL PAPER journal April 2016
Structures of reduced and ligand-bound nitric oxide reductase provide insights into functional differences in respiratory enzymes: Structures of Reduced/Ligand-Bound NOR journal January 2014
Siroheme-containing sulfite reductase: A density functional investigation of the mechanism journal March 2011
Heme FeSO 2− intermediates in sulfite reduction: Contrasts with FeOO 2− species from oxygen-oxygen bond activating systems: SURDUCAN et al .
  • Surducan, Mihai; Brânzanic, Adrian M. V.; Silaghi-Dumitrescu, Radu
  • International Journal of Quantum Chemistry, Vol. 118, Issue 19 https://doi.org/10.1002/qua.25697
journal September 2018
Cytochrome c Oxidase Does Not Catalyze the Anaerobic Reduction of NO journal April 1998
Kinetic Analysis of Substrate Inhibition in Nitric Oxide Reductase of Paracoccus denitrificans journal August 1999
Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module 1 1Edited by R. Huber journal May 2000
Sulfate-Reducing Bacteria January 1995
Formation of thiosulfate and trithionate during sulfite reduction by washed cells of Desulfovibrio desulfuricans journal September 1990
Purification and properties of thiosulfate reductase from Desulfovibrio gigas journal January 1975
Laccases: a never-ending story journal October 2009
Hybrid cluster proteins (HCPs) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at 1.25 Å resolution using synchrotron radiation journal January 2002
Theoretical study of the reduction of nitric oxide in an A-type flavoprotein journal September 2006
The dual function of flavodiiron proteins: oxygen and/or nitric oxide reductases journal January 2016
Bacterial nitric oxide reductase: a mechanism revisited by an ONIOM (DFT:MM) study journal April 2015
Cytochrome c oxidase: exciting progress and remaining mysteries journal October 2008
Studies on yeast sulfite reductase II. Partial purification and properties of genetically incomplete sulfite reductases journal April 1968
Evidence for thiosulfate formation during sulfite reduction by Desulfovibrio vulgaris journal July 1969
Purification of the enzyme reducing bisulfite to trithionate from Desulfovibrio gigas and its identification as desulfoviridin journal November 1971
Regulation of the hexaheme nitrite/nitric oxide reductase of Desulfovibrio desulfuricans, Wolinella succinogenes and Escherichia coli : A mass spectrometric study journal December 1990
Cytochrome oxidase evolved by tinkering with denitrification enzymes journal March 1994
Purification and characterization of bisulfite reductase (desulfofuscidin) from Desulfovibrio thermophilus and its complexes with exogenous ligands journal August 1990
A novel scenario for the evolution of haem–copper oxygen reductases journal June 2001
Purification and initial kinetic and spectroscopic characterization of NO reductase from Paracoccus denitrificans journal January 1997
Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors journal July 1997
Nitric oxide in bacteria: synthesis and consumption journal May 1999
Cytochrome bo3 from Escherichia coli: the binding and turnover of nitric oxide journal September 2002
Oxidation of dithiothreitol during turnover of nitric oxide reductase: evidence for generation of nitroxyl with the enzyme from Paracoccus denitrificans journal March 1992
High voltage redox properties of cytochrome c oxidase journal October 1990
Principles of structure, bonding, and reactivity for metal nitrosyl complexes journal September 1974
The antiquity of microbial sulfate reduction journal February 2004
Dioxygen and nitric oxide reactivity of a reduced heme/non-heme diiron(II) complex [(5L)FeII⋯FeIICl]+. Using a tethered tetraarylporphyrin for the development of an active site reactivity model for bacterial nitric oxide reductase journal January 2000
Characterization of a sulfite reductase from Desulfovibrio vulgaris. Evidence for the presence of a low-spin siroheme and an exchange-coupled siroheme-[4Fe-4S] unit. journal December 1984
Terminal oxidases of Escherichia coli aerobic respiratory chain. I. Purification and properties of cytochrome b562-o complex from cells in the early exponential phase of aerobic growth. journal March 1984
Mössbauer evidence for exchange-coupled siroheme and [4Fe-4S] prosthetic groups in Escherichia coli sulfite reductase. Studies of the reduced states and of a nitrite turnover complex. journal September 1983
Mössbauer studies of Escherichia coli sulfite reductase complexes with carbon monoxide and cyanide. Exchange coupling and intrinsic properties of the [4Fe-4S] cluster. journal September 1983
Evidence for the Identity of the Nicotinamide Adenine Dinucleotide Phosphate-specific Sulfite and Nitrite Reductases of Escherichia coli journal October 1963
The heme and Fe4S4 cluster in the crystallographic structure of Escherichia coli sulfite reductase. journal August 1986
Stopped-flow and rapid-scan studies of the redox behavior of cytochrome aco from facultative alkalophilic Bacillus journal August 1991
Reduced Nicotinamide Adenine Dinucleotide Phosphate-Sulfite Reductase of Enterobacteria journal March 1974
Siroheme and Sirohydrochlorin journal October 1973
Reduced Nicotinamide Adenine Dinucleotide Phosphate-Sulfite Reductase of Enterobacteria journal April 1973
Reduced Nicotinamide Adenine Dinucleotide Phosphate-Sulfite Reductase of Enterobacteria journal January 1973
Mössbauer spectroscopic studies of Escherichia coli sulfite reductase. Evidence for coupling between the siroheme and Fe4S4 cluster prosthetic groups. journal March 1981
Characterization of the cysJIH Regions of Salmonella typhimurium and Escherichia coli B journal September 1989
Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes. journal June 1982
The X-ray Crystal Structures of Wild-type and EQ(I-286) Mutant Cytochrome c Oxidases from Rhodobacter sphaeroides journal August 2002
Plant sulfite reductase: molecular structure, catalytic function and interaction with ferredoxin journal November 2000
Cytochromes P450nor and P450foxy of the fungus Fusarium oxysporum journal November 2002
Metalloprotein and redox protein design journal August 2001
The relationship between structure and function for the sulfite reductases journal December 1996
Transmembrane proton translocation by cytochrome c oxidase journal August 2006
Substrate binding and the catalytic reactions in cbb3-type oxidases: The lipid membrane modulates ligand binding journal June 2010
Electron transfer to the active site of the bacterial nitric oxide reductase is controlled by ligand binding to heme b3 journal April 2011
The O2 reduction and proton pumping gate mechanism of bovine heart cytochrome c oxidase journal October 2011
The cytochrome bd respiratory oxygen reductases journal November 2011
Cytochrome c oxidase: Charge translocation coupled to single-electron partial steps of the catalytic cycle journal April 2012
Functional proton transfer pathways in the heme–copper oxidase superfamily journal April 2012
Active site intermediates in the reduction of O2 by cytochrome oxidase, and their derivatives journal April 2012
Kinetic studies of the reactions of O2 and NO with reduced Thermus thermophilus ba3 and bovine aa3 using photolabile carriers journal April 2012
Electrochemical behaviour of bacterial nitric oxide reductase—Evidence of low redox potential non-heme FeB gives new perspectives on the catalytic mechanism journal March 2013
Steady-state kinetics with nitric oxide reductase (NOR): New considerations on substrate inhibition profile and catalytic mechanism journal March 2014
The causes of reduced proton-pumping efficiency in type B and C respiratory heme-copper oxidases, and in some mutated variants of type A journal July 2014
The pathway of O 2 to the active site in heme–copper oxidases journal January 2015
Infrared and Raman spectroscopic investigation of the reaction mechanism of cytochrome c oxidase journal January 2015
Proton translocation in cytochrome c oxidase: Insights from proton exchange kinetics and vibrational spectroscopy journal January 2015
Protonation of the binuclear active site in cytochrome c oxidase decreases the reduction potential of CuB journal October 2015
Structure and properties of the catalytic site of nitric oxide reductase at ambient temperature journal October 2015
The unusual redox properties of C-type oxidases journal December 2016
The mechanism for oxygen reduction in cytochrome c dependent nitric oxide reductase (cNOR) as obtained from a combination of theoretical and experimental results journal November 2017
Proton pumping by cytochrome c oxidase – A 40 year anniversary journal September 2018
Mechanisms for enzymatic reduction of nitric oxide to nitrous oxide - A comparison between nitric oxide reductase and cytochrome c oxidase journal November 2018
An engineered heme–copper center in myoglobin: CO migration and binding journal September 2013
The role of extended Fe4S4 cluster ligands in mediating sulfite reductase hemoprotein activity journal September 2018
Redox states of Desulfovibrio vulgaris DsrC, a key protein in dissimilatory sulfite reduction journal November 2013
Reductive N–N coupling of NO molecules on transition metal complexes leading to N2O journal March 2012
Mono- and dinuclear non-heme iron–nitrosyl complexes: Models for key intermediates in bacterial nitric oxide reductases journal January 2013
A structural and functional perspective on the evolution of the heme-copper oxidases journal September 2014
An electrogenic nitric oxide reductase journal July 2015
Spectroscopic and electrochemical studies of novel model compounds for cytochrome c oxidase journal June 2010
Nitric oxide reductases of prokaryotes with emphasis on the respiratory, heme?copper oxidase type journal January 2005
Flavodiiron nitric oxide reductases: Recent developments in the mechanistic study and model chemistry for the catalytic reduction of NO journal January 2015
Insights into the recognition and electron transfer steps in nitric oxide reductase from Marinobacter hydrocarbonoclasticus journal December 2017
Importance of the iron–sulfur component and of the siroheme modification in the resting state of sulfite reductase journal February 2020
The structure of the oxidized state of cytochrome c oxidase - experiments and theory compared journal May 2020
Structural Evidence for Direct Hydride Transfer from NADH to Cytochrome P450nor journal September 2004
Structure of the Dissimilatory Sulfite Reductase from the Hyperthermophilic Archaeon Archaeoglobus fulgidus journal June 2008
A Multiplex Enzymatic Machinery for Cellular Protein S-nitrosylation journal February 2018
A bridged di-iron porphyrin hyponitrite complex as a model for biological N2O production from hyponitrite journal January 2016
Was nitric oxide the first deep electron sink? journal January 2009
Evolution of the haem copper oxidases superfamily: a rooting tale journal August 2009
Engineering Metalloprotein Functions in Designed and Native Scaffolds journal December 2019
De novo protein design, a retrospective journal January 2020
Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors journal March 2019
Effect of Outer-Sphere Side Chain Substitutions on the Fate of the trans Iron–Nitrosyl Dimer in Heme/Nonheme Engineered Myoglobins (Fe B Mbs): Insights into the Mechanism of Denitrifying NO Reductases journal March 2016
Mechanism of Oxygen Reduction in Cytochrome c Oxidase and the Role of the Active Site Tyrosine journal January 2016
Structure of the Membrane-intrinsic Nitric Oxide Reductase from Roseobacter denitrificans journal June 2016
Can Reduction of NO to N 2 O in Cytochrome c Dependent Nitric Oxide Reductase Proceed through a Trans-Mechanism? journal December 2016
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies journal May 2017
Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins journal December 2017
Oxygen Activation and Energy Conservation by Cytochrome c Oxidase journal January 2018
Synthetic Fe/Cu Complexes: Toward Understanding Heme-Copper Oxidase Structure and Function journal October 2018
Biological and Bioinspired Inorganic N–N Bond-Forming Reactions journal February 2020
Proton-Assisted Mechanism of NO Reduction on a Dinuclear Ruthenium Complex journal July 2015
Understanding the Role of Hyponitrite in Nitric Oxide Reduction journal April 2015
Broken Symmetry DFT Calculations/Analysis for Oxidized and Reduced Dinuclear Center in Cytochrome c Oxidase: Relating Structures, Protonation States, Energies, and Mössbauer Properties in ba 3 Thermus thermophilus journal July 2015
Recent Advances in Biosynthetic Modeling of Nitric Oxide Reductases and Insights Gained from Nuclear Resonance Vibrational and Other Spectroscopic Studies journal August 2015
Unusual Synthetic Pathway for an {Fe(NO) 2 } 9 Dinitrosyl Iron Complex (DNIC) and Insight into DNIC Electronic Structure via Nuclear Resonance Vibrational Spectroscopy journal May 2016
Dioxygen Binding, Activation, and Reduction to H 2 O by Cu Enzymes journal June 2016
Ferric Heme-Nitrosyl Complexes: Kinetically Robust or Unstable Intermediates? journal August 2017
Mechanism of N–N Bond Formation by Transition Metal–Nitrosyl Complexes: Modeling Flavodiiron Nitric Oxide Reductases journal March 2018
Synthetic Model Complex of the Key Intermediate in Cytochrome P450 Nitric Oxide Reductase journal January 2019
The Thiolate Trans Effect in Heme {FeNO} 6 Complexes and Beyond: Insight into the Nature of the Push Effect journal March 2019
Surface-Enhanced Infrared Absorption Spectroscopy of Bacterial Nitric Oxide Reductase under Electrochemical Control Using a Vibrational Probe of Carbon Monoxide journal August 2018
In Situ Mechanistic Investigation of O 2 Reduction by Iron Porphyrin Electrocatalysts Using Surface-Enhanced Resonance Raman Spectroscopy Coupled to Rotating Disk Electrode (SERRS-RDE) Setup journal September 2016
Spectroscopy and DFT Calculations of Flavo–Diiron Nitric Oxide Reductase Identify Bridging Structures of NO-Coordinated Diiron Intermediates journal October 2018
Heme–Copper/Dioxygen Adduct Formation, Properties, and Reactivity journal July 2007
Enzymic redox chemistry: a proposed reaction pathway for the six-electron reduction of sulfite to sulfide by the assimilatory-type sulfite reductase from Desulfovibrio vulgaris (Hildenborough) journal September 1991
A Novel Copper A Containing Menaquinol NO Reductase from Bacillus azotoforman s † journal February 2001
Electron paramagnetic resonance and optical spectroscopic evidence for interaction between siroheme and iron sulfide (Fe4S4) prosthetic groups in Escherichia coli sulfite reductase hemoprotein subunit journal July 1982
Electron paramagnetic resonance and optical evidence for interaction between siroheme and the tetranuclear iron-sulfur center (Fe4S4) prosthetic groups in complexes of Escherichia coli sulfite reductase hemoprotein with added ligands journal January 1983
Electron-nuclear double resonance studies of oxidized Escherichia coli sulfite reductase: proton, nitrogen-14 and iron-57 measurements journal December 1985
Resonance Raman studies of Escherichia coli sulfite reductase hemoprotein. 3. Bound ligand vibrational modes journal June 1989
Spinach siroheme enzymes: isolation and characterization of ferredoxin-sulfite reductase and comparison of properties with ferredoxin-nitrite reductase journal June 1982
Charge Translocation Coupled to Electron Injection into Oxidized Cytochrome c Oxidase from Paracoccus denitrificans † journal June 2001
Proton and Electron Pathways in the Bacterial Nitric Oxide Reductase † , ⊥ journal February 2002
Intramolecular Proton-Transfer Reactions in a Membrane-Bound Proton Pump:  The Effect of pH on the Peroxy to Ferryl Transition in Cytochrome c Oxidase † , ⊥ journal February 2003
Electron/Proton Coupling in Bacterial Nitric Oxide Reductase during Reduction of Oxygen † journal August 2005
Structure of Spinach Nitrite Reductase:  Implications for Multi-electron Reactions by the Iron−Sulfur:Siroheme Cofactor † , ‡ journal December 2005
Evolutionary Migration of a Post-Translationally Modified Active-Site Residue in the Proton-Pumping Heme-Copper Oxygen Reductases † journal December 2006
The Diheme Cytochrome c 4 from Vibrio cholerae Is a Natural Electron Donor to the Respiratory cbb 3 Oxygen Reductase journal September 2010
Low-Spin Heme b 3 in the Catalytic Center of Nitric Oxide Reductase from Pseudomonas nautica journal May 2011
Spectroscopic Characterization of Mononitrosyl Complexes in Heme–Nonheme Diiron Centers within the Myoglobin Scaffold (Fe B Mbs): Relevance to Denitrifying NO Reductase journal July 2011
Mobility of Xe Atoms within the Oxygen Diffusion Channel of Cytochrome ba 3 Oxidase journal May 2012
Mechanism for N 2 O Generation in Bacterial Nitric Oxide Reductase: A Quantum Chemical Study journal June 2012
Mutational Analysis of Sulfite Reductase Hemoprotein Reveals the Mechanism for Coordinated Electron and Proton Transfer journal November 2012
Thermodynamic Redox Behavior of the Heme Centers of cbb 3 Heme-Copper Oxygen Reductase from Bradyrhizobium japonicum † journal November 2007
Cytochrome bd from Azotobacter vinelandii :  Evidence for High-Affinity Oxygen Binding † journal October 2007
Binding and Reduction of Sulfite by Cytochrome c Nitrite Reductase † , ‡ journal February 2008
Crystallographic Studies of Xe and Kr Binding within the Large Internal Cavity of Cytochrome ba 3 from Thermus thermophilus : Structural Analysis and Role of Oxygen Transport Channels in the Heme−Cu Oxidases † , ‡ journal April 2008
Structures of the Siroheme- and Fe 4 S 4 -Containing Active Center of Sulfite Reductase in Different States of Oxidation:  Heme Activation via Reduction-Gated Exogenous Ligand Exchange † , ‡ journal October 1997
Probing the Catalytic Mechanism of Sulfite Reductase by X-ray Crystallography:  Structures of the Escherichia coli Hemoprotein in Complex with Substrates, Inhibitors, Intermediates, and Products † , ‡ journal October 1997
Isolation and Characterization of Nitric Oxide Reductase from Paracoccus halodenitrificans † journal November 1997
The Active Site of the Bacterial Nitric Oxide Reductase Is a Dinuclear Iron Center † journal September 1998
Intermediates in the Reaction of Fully Reduced Cytochrome c Oxidase with Dioxygen † journal December 1998
Engineering Cytochrome c Peroxidase into Cytochrome P450:  A Proximal Effect on Heme−Thiolate Ligation † journal August 1999
A Low-Redox Potential Heme in the Dinuclear Center of Bacterial Nitric Oxide Reductase: Implications for the Evolution of Energy-Conserving Heme−Copper Oxidases † journal October 1999
Nitric Oxide in Biological Denitrification:  Fe/Cu Metalloenzyme and Metal Complex NO x Redox Chemistry journal April 2002
Functional Analogues of Cytochrome c Oxidase, Myoglobin, and Hemoglobin journal February 2004
Synthetic Models for Heme−Copper Oxidases journal February 2004
Dioxygen Activation at Mononuclear Nonheme Iron Active Sites:  Enzymes, Models, and Intermediates journal February 2004
Structure and Chemistry of Cytochrome P450 journal June 2005
Proton-Coupled Electron Transfer in Cytochrome Oxidase journal December 2010
Copper Active Sites in Biology journal January 2014
Protein Design: Toward Functional Metalloenzymes journal January 2014
How Biology Handles Nitrite journal April 2014
Mechanism of Nitrogen Fixation by Nitrogenase: The Next Stage journal January 2014
Reaction Mechanism of Cytochrome c Oxidase journal January 2015
New Perspectives on Proton Pumping in Cellular Respiration journal February 2015
Multicopper Oxidases and Oxygenases journal January 1996
Electrocatalytic reduction of bisulfite to hydrogen sulfide based on a water-soluble iron porphyrin journal July 1987
Distal Metal Effects in Cobalt Porphyrins Related to C c O journal December 2002
Metal-Bridging Mechanism for O−O Bond Cleavage in Cytochrome c Oxidase journal August 2003
Active-Site Models of Bacterial Nitric Oxide Reductase Featuring Tris-Histidyl and Glutamic Acid Mimics:  Influence of a Carboxylate Ligand on Fe B Binding and the Heme Fe/Fe B Redox Potential journal September 2006
Electronic Structure of a Low-Spin Heme/Cu Peroxide Complex: Spin-State and Spin-Topology Contributions to Reactivity journal November 2011
Role of the Tyr-Cys Cross-link to the Active Site Properties of Galactose Oxidase journal February 2012
Characterization of the Bridged Hyponitrite Complex {[Fe(OEP)] 2 (μ-N 2 O 2 )}: Reactivity of Hyponitrite Complexes and Biological Relevance journal June 2014
Reactivity Studies on Fe III −(O 2 2- )−Cu II Compounds:  Influence of the Ligand Architecture and Copper Ligand Denticity journal August 2007
Reductive Coupling of Nitrogen Monoxide (•NO) Facilitated by Heme/Copper Complexes journal February 2010
Heme−Copper−Dioxygen Complexes: Toward Understanding Ligand-Environmental Effects on the Coordination Geometry, Electronic Structure, and Reactivity journal April 2010
Synthesis of a [Fe 4 S 4 ]−S−Ferriheme Bridged Assembly Containing an Isobacteriochlorin Component:  A Further Analogue of the Active Site of Sulfite Reductase journal January 1996
Functional Analogs of Heme Protein Active Sites † journal November 1997
Reactivity of the Iron Porphyrin Fe(TPP)(NO) with Excess NO. Formation of Fe(TPP)(NO)(NO 2 ) Occurs via Reaction with Trace NO 2 journal February 2000
Synthesis and Electron Delocalization of [Fe4S4]-S-Fe(III) Bridged Assemblies Related to the Exchange-Coupled Catalytic Site of Sulfite Reductases journal August 1994
Direct Reversible Protein Electrochemistry at a Pyrolytic Graphite Electrode. Characterization of the Redox Thermodynamics of the Fe4S4-Siroheme Prosthetic Center in the Hexameric Dissimilatory Sulfite Reductase and the Monomeric Assimilatory Sulfite Reductase from Desulfovibrio vulgaris (Hildenborough). Systematic pH Titration Experiments and Implications for Active Site Chemistry journal December 1994
Sulfite Reductase: Active Site Residues are "Noncatalytic". Comparison of Reaction Energetics for Enzyme- and Siroheme-Catalyzed Reduction of Inorganic Substrates. journal April 1995
Characterization of two dissimilatory sulfite reductases (desulforubidin and desulfoviridin) from the sulfate-reducing bacteria. Moessbauer and EPR studies journal February 1988
Exchange coupling between siroheme and iron-sulfur ([4Fe-4S]) cluster in E. coli sulfite reductase. Moessbauer studies and coupling models for a 2-electron reduced enzyme state and complexes with sulfide journal October 1984
Models for nitrite reductases. Redox chemistry of iron-nitrosyl porphyrins, chlorins, and isobacteriochlorins and .pi. cation radicals of cobalt-nitrosyl isobacteriochlorins journal October 1983
Radicals of isobacteriochlorins: models of siroheme and sirohydrochlorin journal December 1979
Models of siroheme and sirohydrochlorin. .pi. Cation radicals of iron(II) isobacteriochlorin journal January 1980
Dioxygen Reactivity of Mononuclear Heme and Copper Components Yielding A High-Spin Heme−Peroxo−Cu Complex journal June 2001
Functional Analogues of the Dioxygen Reduction Site in Cytochrome Oxidase:  Mechanistic Aspects and Possible Effects of Cu B journal October 2002
Spectroscopic Evidence for a Heme−Superoxide/Cu(I) Intermediate in a Functional Model of Cytochrome c Oxidase journal June 2003
Photoinduced Carbon Monoxide Migration in a Synthetic Heme−Copper Complex journal May 2005
Two CO Molecules Can Bind Concomitantly at the Diiron Site of NO Reductase from Bacillus a zotoformans journal December 2004
Heme/Non-Heme Diiron(II) Complexes and O 2 , CO, and NO Adducts as Reduced and Substrate-Bound Models for the Active Site of Bacterial Nitric Oxide Reductase journal March 2005
Midpoint Potentials of Hemes a and a 3 in the Quinol Oxidase from Acidianus ambivalens are Inverted journal October 2005
Catalytic Reduction of NO to N 2 O by a Designed Heme Copper Center in Myoglobin:  Implications for the Role of Metal Ions journal May 2006
Intramolecular Single-Turnover Reaction in a Cytochrome c Oxidase Model Bearing a Tyr244 Mimic journal May 2007
Reversible N−N Coupling of NO Ligands on Dinuclear Ruthenium Complexes and Subsequent N 2 O Evolution:  Relevance to Nitric Oxide Reductase journal November 2007
Structural and Electronic Characterization of Non-Heme Fe(II)–Nitrosyls as Biomimetic Models of the Fe B Center of Bacterial Nitric Oxide Reductase journal October 2011
Two Tyrosyl Radicals Stabilize High Oxidation States in Cytochrome c Oxidase for Efficient Energy Conservation and Proton Translocation journal March 2012
Direct EPR Observation of a Tyrosyl Radical in a Functional Oxidase Model in Myoglobin during both H 2 O 2 and O 2 Reactions journal January 2014
The Production of Nitrous Oxide by the Heme/Nonheme Diiron Center of Engineered Myoglobins (Fe B Mbs) Proceeds through a trans -Iron-Nitrosyl Dimer journal January 2014
Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs journal April 2015
A “Naked” Fe III -(O 2 2– )-Cu II Species Allows for Structural and Spectroscopic Tuning of Low-Spin Heme-Peroxo-Cu Complexes journal January 2015
Intermediates Involved in the Two Electron Reduction of NO to N 2 O by a Functional Synthetic Model of Heme Containing Bacterial NO Reductase journal December 2008
Heme-Copper Assembly Mediated Reductive Coupling of Nitrogen Monoxide (·NO) journal January 2009
A Stable Hyponitrite-Bridged Iron Porphyrin Complex journal February 2009
Iron-Porphyrin NO Complexes with Covalently Attached N-Donor Ligands: Formation of a Stable Six-Coordinate Species in Solution journal December 2009
Carbon Monoxide and Nitrogen Monoxide Ligand Dynamics in Synthetic Heme and Heme−Copper Complex Systems journal October 2009
Role of Copper Ion in Regulating Ligand Binding in a Myoglobin-Based Cytochrome c Oxidase Model journal February 2010
Insights into the Functional Role of the Tyrosine−Histidine Linkage in Cytochrome c Oxidase journal March 2000
Electrocatalytic O 2 -Reduction by Synthetic Cytochrome c Oxidase Mimics: Identification of a “Bridging Peroxo” Intermediate Involved in Facile 4e – /4H + O 2 -Reduction journal September 2015
A Designed Metalloenzyme Achieving the Catalytic Rate of a Native Enzyme journal September 2015
Spectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin journal January 2016
Critical Aspects of Heme–Peroxo–Cu Complex Structure and Nature of Proton Source Dictate Metal–O peroxo Breakage versus Reductive O–O Cleavage Chemistry journal December 2016
Phenol-Induced O–O Bond Cleavage in a Low-Spin Heme–Peroxo–Copper Complex: Implications for O 2 Reduction in Heme–Copper Oxidases journal June 2017
Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism journal August 2017
Lewis Acid Activation of the Ferrous Heme–NO Fragment toward the N–N Coupling Reaction with NO To Generate N 2 O journal February 2018
Non-Heme Diiron Model Complexes Can Mediate Direct NO Reduction: Mechanistic Insight into Flavodiiron NO Reductases journal September 2018
Nitric Oxide Reductase Activity in Heme–Nonheme Binuclear Engineered Myoglobins through a One-Electron Reduction Cycle journal November 2018
Geometric and Electronic Structure Contributions to O–O Cleavage and the Resultant Intermediate Generated in Heme-Copper Oxidases journal May 2019
Functional Models for the Mono- and Dinitrosyl Intermediates of FNORs: Semireduction versus Superreduction of NO journal March 2020
Direct Hydride Shift Mechanism and Stereoselectivity of P450 nor Confirmed by QM/MM Calculations journal December 2011
Model Studies of the Histidine-Tyrosine Cross-Link in Cytochrome c Oxidase Reveal the Flexible Substituent Effect of the Imidazole Moiety journal June 2005
Heme Centers of Rhodothermus marinus Respiratory Chain. Characterization of Its cbb3 Oxidase journal January 2000
Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans journal August 1995
Reduction of cytochrome c oxidase by a second electron leads to proton translocation journal May 2002
Rational design of a structural and functional nitric oxide reductase journal November 2009
The octahaem MccA is a haem c–copper sulfite reductase journal February 2015
Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases journal November 2016
Versatility of biological non-heme Fe(II) centers in oxygen activation reactions journal February 2008
A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction journal October 2015
Crystal structure of nitric oxide reductase from denitrifying fungus Fusarium oxysporum journal October 1997
Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus journal January 2012
An electrogenic redox loop in sulfate reduction reveals a likely widespread mechanism of energy conservation journal December 2018
Homologous bd oxidases share the same architecture but differ in mechanism journal November 2019
Characterization of the quinol-dependent nitric oxide reductase from the pathogen Neisseria meningitidis, an electrogenic enzyme journal February 2018
Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase journal December 2019
N2O production, a widespread trait in fungi journal April 2015
Formation and spectroscopic characterization of the dioxygen adduct of a heme–Cu complex possessing a cross-linked tyrosine–histidine mimic: modeling the active site of cytochrome c oxidase journal January 2004
Spectroscopic characterization of heme iron–nitrosyl species and their role in NO reductase mechanisms in diiron proteins journal January 2007
Single-turnover intermolecular reaction between a Fe iii –superoxide–Cu i cytochrome c oxidase model and exogeneous Tyr244 mimics journal January 2006
Engineering enzymes journal January 2011
Dinuclear heme and non-heme metal complexes as bioinspired catalysts for oxidation reactions journal January 2014
Design and engineering of artificial oxygen-activating metalloenzymes journal January 2016
A broken-symmetry density functional study of structures, energies, and protonation states along the catalytic O–O bond cleavage pathway in ba 3 cytochrome c oxidase from Thermus thermophilus journal January 2016
Diiron monooxygenases in natural product biosynthesis journal January 2018
A water-soluble supramolecular complex that mimics the heme/copper hetero-binuclear site of cytochrome c oxidase journal January 2018
Why does sulfite reductase employ siroheme? journal January 2019
A new dinuclear heme-copper complex derived from functionalized protoporphyrin IX journal January 2007
Flavo-diiron enzymes: nitric oxide or dioxygen reductases? journal January 2007
Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase journal January 2008
A novel variant of ferredoxin-dependent sulfite reductase having preferred substrate specificity for nitrite in the unicellular red alga Cyanidioschyzon merolae journal September 2009
The alternative oxidases: simple oxidoreductase proteins with complex functions journal September 2013
Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies journal June 2017
Reactions of cytochrome oxidase with oxygen and carbon monoxide journal March 1963
The nitric oxide reductase of Paracoccus denitrificans journal July 1990
Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide journal April 1996
The cytochrome cbb 3 from Pseudomonas stutzeri displays nitric oxide reductase activity : NO reductase activity of cytochrome journal December 2001
Electrochemical, FT-IR and UV/VIS spectroscopic properties of the caa 3 oxidase from T. thermophilus: Characterization of T. thermophilus caa 3 oxidase journal September 2002
The catalytic cycle of cytochrome c oxidase is not the sum of its two halves journal December 2003
Exploring the proton pump mechanism of cytochrome c oxidase in real time journal February 2007
The origin of atmospheric oxygen on Earth: The innovation of oxygenic photosynthesis journal February 2001
The role of copper and protons in heme-copper oxidases: Kinetic study of an engineered heme-copper center in myoglobin journal March 2003
Vectorial proton transfer coupled to reduction of O2 and NO by a heme-copper oxidase journal December 2008
A functional nitric oxide reductase model journal October 2008
Water may inhibit oxygen binding in hemoprotein models journal February 2009
Role of a distal pocket in the catalytic O2 reduction by cytochrome c oxidase models immobilized on interdigitated array electrodes journal April 2009
O2 reduction by a functional heme/nonheme bis-iron NOR model complex journal June 2009
The cytochrome ba3 oxygen reductase from Thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping journal September 2009
Bovine cytochrome c oxidase structures enable O 2 reduction with minimization of reactive oxygens and provide a proton-pumping gate journal April 2010
Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin journal April 2010
Kinetic design of the respiratory oxidases journal June 2011
Homogeneous catalytic O2 reduction to water by a cytochrome c oxidase model with trapping of intermediates and mechanistic insights journal August 2011
Entrance of the proton pathway in cbb3-type heme-copper oxidases journal October 2011
Structure of the trypanosome cyanide-insensitive alternative oxidase journal March 2013
Computational study of the activated OH state in the catalytic mechanism of cytochrome c oxidase journal September 2013
Heme redox potentials hold the key to reactivity differences between nitric oxide reductase and heme-copper oxidase journal May 2018
Siroheme: A New Prosthetic Group Participating in Six-Electron Reduction Reactions Catalyzed by Both Sulfite and Nitrite Reductases journal March 1974
Properties of a copper-containing cytochrome c1aa3 complex: a terminal oxidase of the extreme thermophile Thermus thermophilus HB8. journal January 1980
  cation radicals of ferrous and free base isobacteriochlorins: Models for siroheme and sirohydrochlorin journal May 1981
Thermodynamics of electron transfer in Escherichia coli cytochrome bo3 journal September 1998
The heme-copper oxidases of Thermus thermophilus catalyze the reduction of nitric oxide: Evolutionary implications journal December 1999
A Simplifed Functional Version of the Escherichia coli Sulfite Reductase journal September 2000
Substrate Control of Internal Electron Transfer in Bacterial Nitric-oxide Reductase journal August 2010
The Mg 2+ -containing Water Cluster of Mammalian Cytochrome c Oxidase Collects Four Pumping Proton Equivalents in Each Catalytic Cycle journal September 2016
Redox-dependent Open and Closed Forms of the Active Site of the Bacterial Respiratory Nitric-oxide Reductase Revealed by Cyanide Binding Studies journal April 2004
NO Reduction by Nitric-oxide Reductase from Denitrifying Bacterium Pseudomonas aeruginosa : CHARACTERIZATION OF REACTION INTERMEDIATES THAT APPEAR IN THE SINGLE TURNOVER CYCLE journal October 2004
Siroheme- and [Fe 4 -S 4 ]-dependent NirA from Mycobacterium tuberculosis Is a Sulfite Reductase with a Covalent Cys-Tyr Bond in the Active Site journal May 2005
The Role of the Hybrid Cluster Protein in Oxidative Stress Defense journal August 2006
Defining the Proton Entry Point in the Bacterial Respiratory Nitric-oxide Reductase journal February 2008
Discovery of the True Peroxy Intermediate in the Catalytic Cycle of Terminal Oxidases by Real-time Measurement journal September 2007
The Crystal Structure of Desulfovibrio vulgaris Dissimilatory Sulfite Reductase Bound to DsrC Provides Novel Insights into the Mechanism of Sulfate Respiration journal September 2008
A QM/MM study of nitric oxide reductase-catalysed N 2 O formation journal September 2013
Structure and mechanism of the aberrant ba3-cytochrome c oxidase from Thermus thermophilus journal April 2000
Diversity and complexity of flavodiiron NO/O2 reductases journal December 2017
Characterization of two ferredoxin-dependent sulfite reductases having different substrate specificity in the red alga Cyanidioschyzon merolae journal January 2017
Enzymatic Steps of Dissimilatory Nitrite Reduction in Alcaligenes faecalis journal May 1971
Siroheme as an Active Catalyst in Sulfite Reduction journal October 1981
Some Properties of Sulfite Reductase from Yeast journal June 1965
Functions of the hydrophilic channels in protonmotive cytochrome c oxidase journal September 2013
Structural basis for nitrous oxide generation by bacterial nitric oxide reductases journal May 2012
Fungal denitrification and nitric oxide reductase cytochrome P450nor journal May 2012
Bacterial respiration: a flexible process for a changing environment journal March 2000
Structural and functional relationships in the hybrid cluster protein family: structure of the anaerobically purified hybrid cluster protein from Desulfovibrio vulgaris at 1.35 Å resolution journal May 2008
The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer journal March 2020
Organohalide respiration in pristine environments: implications for the natural halogen cycle: Organohalide respiration in pristine environments journal December 2017
A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding journal May 2007
Structural insights into the enzyme catalysis from comparison of three forms of dissimilatory sulphite reductase from Desulfovibrio gigas: Structures of D. gigas dissimilatory sulphite reductases journal September 2010
The Wolinella succinogenes mcc gene cluster encodes an unconventional respiratory sulphite reduction system: The respiratory Mcc sulphite reduction system journal November 2011
S = 9/2 EPR signals are evidence against coupling between the siroheme and the Fe/S cluster prosthetic groups in Desulfovibrio vulgaris (Hildenborough) dissimilatory sulfite reductase journal January 1991
Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough) journal June 1992
Desulfoviridin, a multimeric-dissimilatory sulfite reductase from Desulfovibrio vulgaris (Hildenborough) Purification, characterization, kinetics and EPR studies journal July 1994
Molecular Properties of the Dissimilatory Sulfite Reductase from Desulfovibrio Desulfuricans (Essex) and Comparison with the Enzyme from Desulfovibrio Vulgaris (Hildenborough) journal November 1995
Dissimilatory Sulfite Reductase Revisited. The Desulfoviridin Molecule does Contain 20 Iron Ions, Extensively Demetallated Sirohaem, and an S= 9/2 Iron-Sulfur Cluster journal June 1996
Evolution of an octahaem cytochrome c protein family that is key to aerobic and anaerobic ammonia oxidation by bacteria journal November 2008
The roles of the hybrid cluster protein, Hcp and its reductase, Hcr, in high affinity nitric oxide reduction that protects anaerobic cultures of E scherichia coli against nitrosative stress: NO reduction by the E. coli hybrid cluster protein journal March 2016
Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo–electron microscopy journal August 2019
The Effect of Oxygen on Biochemical Networks and the Evolution of Complex Life journal March 2006
A Cytochrome c Oxidase Model Catalyzes Oxygen to Water Reduction Under Rate-Limiting Electron Flux journal March 2007
The Microbial Engines That Drive Earth's Biogeochemical Cycles journal May 2008
The Structure of cbb3 Cytochrome Oxidase Provides Insights into Proton Pumping journal June 2010
Structural Basis of Biological N2O Generation by Bacterial Nitric Oxide Reductase journal November 2010
Sulfite Reductase Structure at 1.6  : Evolution and Catalysis for Reduction of Inorganic Anions journal October 1995
The Whole Structure of the 13-Subunit Oxidized Cytochrome c Oxidase at 2.8 A journal May 1996
A Functional Model Related to Cytochrome c Oxidase and Its Electrocatalytic Four-Electron Reduction of O 2 journal February 1997
Oxygen Activation and Reduction in Respiration: Involvement of Redox-Active Tyrosine 244 journal November 2000
A protein trisulfide couples dissimilatory sulfate reduction to energy conservation journal December 2015
Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases journal April 2016
A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme journal September 2018
Cell biology and molecular basis of denitrification. journal January 1997
Denitrification: production and consumption of nitric oxide. journal January 1994
Carbon Monoxide-Reacting Pigment from Desulfotomaculum nigrificans and Its Possible Relevance to Sulfite Reduction journal January 1970
Thiosulfate Reductase of Desulfovibrio vulgaris journal January 1971
Isolation of Assimilatory- and Dissimilatory-Type Sulfite Reductases from Desulfovibrio vulgaris journal January 1973
Isolation of a Bisulfite Reductase Activity from Desulfotomaculum nigrificans and Its Identification as the Carbon Monoxide-Binding Pigment P582 journal January 1973
Are thiosulfate and trithionate intermediates in dissimilatory sulfate reduction? journal January 1975
Dissimilatory reduction of bisulfite by Desulfovibrio vulgaris. journal January 1978
Characterization of a New Type of Dissimilatory Sulfite Reductase Present in Thermodesulfobacterium commune journal January 1983
Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri. journal June 1989
The superfamily of heme-copper respiratory oxidases. journal September 1994
Cytochrome cb-type nitric oxide reductase with cytochrome c oxidase activity from Paracoccus denitrificans ATCC 35512. journal January 1996
Two Conserved Glutamates in the Bacterial Nitric Oxide Reductase Are Essential for Activity but Not Assembly of the Enzyme journal January 2001
Hydroxylamine Reductase Activity of the Hybrid Cluster Protein from Escherichia coli journal November 2002
Novel Genes of the dsr Gene Cluster and Evidence for Close Interaction of Dsr Proteins during Sulfur Oxidation in the Phototrophic Sulfur Bacterium Allochromatium vinosum journal February 2005
S- and N-Oxide Reductases journal April 2007
Biosynthesis of Cysteine journal September 2008
Unraveling the Heater: New Insights into the Structure of the Alternative Oxidase journal April 2013
THE EARLY HISTORY OF ATMOSPHERIC OXYGEN: Homage to Robert M. Garrels journal May 2005
Timing of NO Binding and Protonation in the Catalytic Reaction of Bacterial Nitric Oxide Reductase as Established by Time-Resolved Spectroscopy journal July 2020
Molecular Dynamics Simulations Reveal Proton Transfer Pathways in Cytochrome C-Dependent Nitric Oxide Reductase journal August 2012
Redox Properties of Thermus thermophilus ba3: Different Electron-Proton Coupling in Oxygen Reductases? journal March 2008
Diversifying Anaerobic Respiration Strategies to Compete in the Rhizosphere journal November 2018
Structural Insights into Dissimilatory Sulfite Reductases: Structure of Desulforubidin from Desulfomicrobium Norvegicum journal January 2011
Alternative Oxidase: A Mitochondrial Respiratory Pathway to Maintain Metabolic and Signaling Homeostasis during Abiotic and Biotic Stress in Plants journal March 2013
Siroheme: An essential component for life on earth journal January 2010
Flavodiiron proteins 1–to-4 function in versatile combinations in O2 photoreduction in cyanobacteria journal July 2019

Similar Records

A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme
Journal Article · Thu Sep 13 20:00:00 EDT 2018 · Science · OSTI ID:1470758
A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme
Journal Article · Thu Sep 13 00:00:00 EDT 2018 · Science · OSTI ID:1490222

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY